{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:33:51Z","timestamp":1758962031509,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To investigate the levels of pregnancy-associated plasma protein A (PAPP-A) or insulin-like growth factor -1 (IGF-1) in patients with acute coronary syndrome. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Serum PAPP-A and IGF-1 was measured with biotin\u2013tyramide-amplified enzyme immunoassay and Enzyme Linked Immuoserbent Assay, respectively, in patients with ST elevation acute myocardial infarction (STEMI, n=12), unstable angina (UAP, n=15), and stable angina (n=15). PAPP-A and IGF-1 was also measured in 16 healthy subjects (control group). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The serum levels of PAPP-A in the STEMI (16.9\u00b110.3 mIU\/L) and UAP group (15.2\u00b110.5 mIU\/L) were higher than in the stable angina (8.5\u00b13.1 mIU\/L) or control group (8.4\u00b12.0 mIU\/L, P &lt; 0.01). The serum levels of IGF-1 in the STEMI (132.3\u00b140.9 \u00b5g\/L) and UAP group (127.3\u00b136.0 \u00b5g\/L) were also higher than in the stable angina (44.9\u00b118.5 \u00b5g\/L) or control group (67.7\u00b124.5\u00b5g\/L, P &lt; 0.01). There were no differences in serum levels of PAPP-A or IGF-1 among the single, double and three vessel lesion groups. The serum levels of PAPP-A (19.9\u00b110.1 mIU\/L) and IGF-1 (153.2\u00b152.4 \u00b5g\/L) after PCI were higher than those before PCI (15.1\u00b110.0 mIU\/L and 91.4\u00b151.0 \u00b5g\/L, respectively, P &lt; 0.01). A positive correlation was found between PAPP-A and IGF-1 levels in the STEMI and UAP group before PCI (r=0.48?P &lt; 0.01). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> PAPP-A and IGF-1 are elevated in patients with acute coronary syndrome. They may be used as biomarkers for vulnerable plaques in patients with coronary artery disease. Whether post-PCI elevation of IGF-1 can be used to predict restenosis of coronary arteries remains to be seen. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v31i2.3368","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:26:13Z","timestamp":1493767573000},"page":"E85-E89","source":"Crossref","is-referenced-by-count":9,"title":["Levels of pregnancy-associated plasma protein A in patients with coronary artery disease"],"prefix":"10.3138","volume":"31","author":[{"given":"Zhi-Yuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."},{"name":"Department of Cardiology, Nanyang Central Hospital, Nanyang, Hennan 473009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong-Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le-Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/3368\/1495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v31i2.3368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:24:21Z","timestamp":1741890261000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v31i2.3368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4,1]]}},"alternative-id":["10.25011\/cim.v31i2.3368"],"URL":"https:\/\/doi.org\/10.25011\/cim.v31i2.3368","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2008,4,1]]}}}