{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:56:31Z","timestamp":1760889391234,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To examines the hypothesis that smoking exacerbates health problems in young male smokers (age range, 18.6-22.8 yr; mean, 19.4 yr). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> 1169 subjects were recruited, 25.41 % were smokers (2-15 cigarettes daily). All subjects were examined for body mass index, blood pressure, exhaled carbon monoxide content (carboxyl hemoglobin), blood hematology and biochemistry. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Data for WBC (P &lt; 0.001), hemoglobin (P=0.001), hematocrit (P=0.004), MCV (P=0.001), MCH (P=0.003), COHB% (P &lt; 0.001), albumin\/globulin (P &lt; 0.001) and triglyceride (P &lt; 0.001) were higher for smokers than non-smokers, while total-bilirubin (P &lt; 0.001), total protein (P &lt; 0.001) and globulin (P &lt; 0.001) were markedly lower. The results of WBC (r=0.164, P &lt; 0.004), COHB% (r=0.958, P &lt; 0.001), gamma glutamyl transpeptidase (r=0.159, P=0.006), alkaline-phosphatase (r=-0.154, P=0.008) and triglyceride (r=0.144, P &lt; 0.001) were closely correlated with number of cigarettes smoked daily. Investigation of associations with illness revealed that young smokers had an increased risk of hypertriglyceridemia to young non-smokers (adjusted ORs, 2.124; 95% CIs, 1.414-3.190), hyperglycemia (adjusted ORs, 1.980; 95% CIs, 0.803-4.901), neutrophilia (adjusted ORs, 1.947; 95% CIs, 1.248-3.037), RBC macrocytosis (adjusted ORs, 1.929; 95% CIs, 1.137-3.275), hyperchromia (adjusted ORs, 1.844; 95% CIs, 1.412-2.407) and polycythemia (adjusted ORs, 1.314; 95% CIs, 0.805-2.145) (all P &lt; 0.05 for linear trends). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The findings emphasize the importance of increasing surveillance of diseases exacerbated by smoking and reducing smoking in the young to prevent cardiovascular illnesses, metabolite disorders and other clinical diseases. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v31i3.3471","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:26:13Z","timestamp":1493767573000},"page":"E138-E149","source":"Crossref","is-referenced-by-count":13,"title":["Cigarette smoking exacerbates health problems in young men"],"prefix":"10.3138","volume":"31","author":[{"given":"Chien-Min","family":"Kung","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology, College of Biomedical Science and Technology, Yuanpei University, Hsinchu, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Lung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology, College of Biomedical Science and Technology, Yuanpei University, Hsinchu, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zu-Lin","family":"Tseng","sequence":"additional","affiliation":[{"name":"Public Health Center of Banciao city, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/3471\/1532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/3471\/3567","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v31i3.3471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:26:52Z","timestamp":1741890412000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v31i3.3471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6,1]]}},"alternative-id":["10.25011\/cim.v31i3.3471"],"URL":"https:\/\/doi.org\/10.25011\/cim.v31i3.3471","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2008,6,1]]}}}