{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T22:45:44Z","timestamp":1759099544908,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The primary aim of the study was to investigate the effect of sinvastatin on plasma interleukin-6 (IL-6) in patients with unstable angina pectoris (UAP). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Eighty-six patients with UAP were randomized into simvastatin (40 mg\/d for 4 weeks) and the placebo group. Plasma IL-6 was measured by ELISA. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> There was a reduction in the plasma total cholesterol and LDL in the simvastatin group (P &lt; 0.01). The simvastatin group also had better angina control than the placebo group (post-treatment angina score, 0.72\u00b10.59 vs 1.07\u00b10.76, P &lt; 0.05). Following treatment, the average left ventricular ejection fraction in the simvastatin group was higher than in the placebo group (0.54\u00b10.06 vs 0.51\u00b10.05, P &lt; 0.05), whereas the plasma BNP levels were lower (16.8\u00b16.6 vs 26.4\u00b11.4, P &lt; 0.01). Before treatment, there was no difference in the plasma levels of IL-6 between the simvastatin and the placebo groups (P &gt; 0.05). Following treatment, the IL-6 levels in the simvastatin group were lower than in the placebo group (0.7\u00b10.4 vs 1.2\u00b10.4 pg\/ml, P &lt; 0.05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Short-term treatment with simvastatin reduces plasma IL-6. The anti-inflammatory effect of simvastatin may contribute to its beneficial effects on the ventricular function and angina control. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v32i4.6619","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:23:03Z","timestamp":1493767383000},"page":"E280-E284","source":"Crossref","is-referenced-by-count":7,"title":["Effect of simvastatin on plasma interleukin-6 in patients with unstable angina"],"prefix":"10.3138","volume":"32","author":[{"given":"Hai-Zhou","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Cardiology, Liaocheng People\u2019s Hospital, Liaocheng City, Shandong Province, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long-Le","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Liaocheng People\u2019s Hospital, Liaocheng City, Shandong Province, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le-Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/6619\/3642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/6619\/3650","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v32i4.6619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:24:02Z","timestamp":1741890242000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v32i4.6619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8,1]]}},"alternative-id":["10.25011\/cim.v32i4.6619"],"URL":"https:\/\/doi.org\/10.25011\/cim.v32i4.6619","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2009,8,1]]}}}