{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:14:41Z","timestamp":1762161281505,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To investigate diagnostic values of pleural fluid matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitors of metalloproteinase-1 (TIMP-1) and TIMP-2 measurements in tuberculous pleurisy(TP) and malignat pleurisy (MP). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> The study included 24 patients with TP, 22 patients with MP and 15 patients with pleural effusion of non-tuberculous and non-malignant origin as controls. MMP-2,-9 and TIMP-1,-2 levels in pleural fluid were measured by ELISA method. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Pleural fluid MMP-2 and MMP-9 levels were higher (P &lt; 0.001, P &lt; 0.001, respectively) in TP than in MP and controls. MP patients have higher pleural fluid MMP-2 and MMP-9 levels (P &lt; 0.01, P &lt; 0.05, respectively) than controls. Pleural fluid TIMP-2 levels were higher (P &lt; 0.01 and P &lt; 0.001, respectively) in MP than in TP and controls. Pleural fluid MMP-9 levels were negatively correlated with pleural fluid TIMP-2 levels (r: 0.464, P=0.029) in patients with MP. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Determination of TIMP-2 in pleural fluid may contribute to differentiate TP from MP. These results suggest that overproduction of MMP-9 and TIMP-2 is associated with accumulation of the pleural effusion in malignancy. Further studies with a greater number of patients are needed to confirm this hypothesis. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v32i4.6621","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:23:03Z","timestamp":1493767383000},"page":"E293-E300","source":"Crossref","is-referenced-by-count":16,"title":["Potential role of matrix metalloproteinase-2,-9 and tissue inhibitors of metalloproteinase-1,-2 in exudative pleural effusions"],"prefix":"10.3138","volume":"32","author":[{"given":"S","family":"Vatansever","sequence":"first","affiliation":[{"name":"Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Gelisgen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Faculty of Cerrahpa\u015fa, University of Istanbul, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Faculty of Cerrahpa\u015fa, University of Istanbul, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Yurt","sequence":"additional","affiliation":[{"name":"Yedikule Chest Disease and Chest Surgery Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Kosar","sequence":"additional","affiliation":[{"name":"Yedikule Chest Disease and Chest Surgery Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/6621\/3644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/6621\/3652","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v32i4.6621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:24:04Z","timestamp":1741890244000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v32i4.6621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8,1]]}},"alternative-id":["10.25011\/cim.v32i4.6621"],"URL":"https:\/\/doi.org\/10.25011\/cim.v32i4.6621","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2009,8,1]]}}}