{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:54:12Z","timestamp":1752360852543,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Immunodeficiency with a thymoma (Good\u2019s syndrome) is a rare condition occurring in patients with adult-onset hypogammaglobulinaemia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical report<\/jats:title><jats:p> We describe the case of a 38-yr-old woman with an upper mediastinal mass and inflammatory infiltrations in the lungs. After thymectomy, the patient\u2019s condition did not improve. The HRCT scan showed bronchiectasies with parenchymal opacities. As pulmonary infection persisted despite wide spectrum antibiotic therapy, additional tests were performed to diagnose an immunodeficiency. Serum immunoglobulin levels were very low. T cell response to mitogens was normal, but to Staphylococcus aureus Cowan I was impaired. Immunophenotyping of peripheral blood and bone marrow aspirate showed a very low number of B-cell at all the stages of development (CD10+CD19+, CD5+CD20). In peripheral blood 2.5% of CD19+ lymphocytes were found. On the basis of clinical history and immunological analysis, Good\u2019s syndrome was recognized. Treatment with intravenous gammaglobulin and antibiotics improved the patient\u2019s performance. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Measurement of serum immunoglobulin concentration is recommended for all patients suspected of thymoma. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v32i4.6622","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:23:03Z","timestamp":1493767383000},"page":"E301-E306","source":"Crossref","is-referenced-by-count":10,"title":["Immunological disturbances in Good\u2019s syndrome"],"prefix":"10.3138","volume":"32","author":[{"given":"Justyna","family":"Fijolek","sequence":"first","affiliation":[{"name":"Institute of Tuberculosis and Lung Diseases Warsaw Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elzbieta","family":"Wiatr","sequence":"additional","affiliation":[{"name":"Institute of Tuberculosis and Lung Diseases Warsaw Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Demkow","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz Maria","family":"Orlowsk","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/6622\/3645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/6622\/3653","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v32i4.6622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:24:06Z","timestamp":1741890246000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v32i4.6622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8,1]]}},"alternative-id":["10.25011\/cim.v32i4.6622"],"URL":"https:\/\/doi.org\/10.25011\/cim.v32i4.6622","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2009,8,1]]}}}