{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:14:22Z","timestamp":1773173662498,"version":"3.50.1"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To investigate the expression and quantity of glucocorticoid receptor-\u03b1 and -\u03b2 in polyp tissues taken from the patients treated were subsequently treated with topical glucocorticoid (GC). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Eighty patients with nasal polyps were initially enrolled in the study. All polyp specimens were obtained prior to treatment. Patients then received daily topical GC spray treatment for one month. Polyp specimens were tested for glucocorticoid receptor (GR) GR-\u03b1 and GR-\u03b2 mRNA expression using fluorescent quantitative-reverse transcription-polymerase chain reaction (FQ-RT-PCR). Thirty healthy nasal mucosa tissue samples were tested at the same time. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Forty patients finished the study and were divided into two groups: GC-sensitive (n=26) and GC-insensitive (n=14), according to treatment results. GR-\u03b2 mRNA expression in the nasal polyp tissues of the GC-insensitive group (5.72\u00b10.58\u00d7102 copies\/\u03bcg) was higher than that in the GC-sensitive group (4.82\u00b10.28\u00d7102 copies\/\u03bcg, P &lt; 0.05) and in the normal nasal mucosa group (4.44\u00b10.35\u00d7102 copies\/\u03bcg, P &lt; 0.01). There was also a difference in the relative expression of GR-\u03b1 and GR-\u03b2 between the GC-sensitive group (GR-\u03b1\/GR-\u03b2= 829.42\u00b167.36) and the GC-insensitive group (535.7\u00b189) (P &lt; 0.01). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> GR-\u03b2 mRNA was highly expressed in patients with nasal polyps. Down- regulation of GR-\u03b1 mRNA suggests the existence of glucocorticoid insensitivity. Expression of GR-\u03b2 may plays an important role in the evaluation of the glucocorticoid therapeutic effect in patients with nasal polyps. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v33i3.13724","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:20:42Z","timestamp":1493767242000},"page":"E181-E188","source":"Crossref","is-referenced-by-count":13,"title":["Glucocorticoid receptor expression and glucocorticoid therapeutic effect in nasal polyps"],"prefix":"10.3138","volume":"33","author":[{"given":"Peng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510630 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510630 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510630 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-Tai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510630 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge-Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510630 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/13724\/10604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v33i3.13724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:13:30Z","timestamp":1741889610000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v33i3.13724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6,1]]}},"alternative-id":["10.25011\/cim.v33i3.13724"],"URL":"https:\/\/doi.org\/10.25011\/cim.v33i3.13724","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,1]]}}}