{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T19:10:25Z","timestamp":1741893025150,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Post-surgial adhesion formation can result in significant morbidity and mortality. N,O-carboxymethyl chitosan (N,O-CMC) has been previously shown to be effective in the prevention of postsurgical adhesion formation. In this study, we evaluated the ability of O-carboxymethyl chitosan (O-CMC), another chitosan derivative generated by carboxymethylation of chitosan's oxygen centers, to reduce postsurgical adhesion development. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Twenty male Sprague-Dawley rats (250 \u00b1 20 g) were divided into two equal groups: O-CMC group and saline (control) group. All rats underwent a midline laparotomy and the cecum was abraded to cause petechial hemorrhages. Following peritoneal injections of either saline or O-CMC, the incisions were closed. Seven days after surgery, the animals were killed and adhesion formation was scored. Tissue samples from the adhesions were examined histochemically. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Adhesion formation was significantly decreased in the O-CMC group (P &lt; .001) in comparison with the control group. Furthermore, significantly less collagen (P &lt; .001) and fewer inflammatory cells and fibroblasts were detected in the O-CMC-treated animals. Additionally, a significantly (P &lt; .05) lower level of TGF-\u03b21 expression was found in the O-CMC group. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> O-CMC appears to be effective in the prevention of postoperative peritoneal adhesion formation, which may be attributed to decreased accumulation of inflammatory cells and fibroblasts and reduced collagen synthesis. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v33i4.14228","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:20:42Z","timestamp":1493767242000},"page":"E254-E260","source":"Crossref","is-referenced-by-count":7,"title":["Prevention of postoperative peritoneal adhesions by O-carboxymethyl chitosan in a rat cecal abrasion model"],"prefix":"10.3138","volume":"33","author":[{"given":"Dejuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiacong","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirong","family":"Pan","sequence":"additional","affiliation":[{"name":"Cardiovascular Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haofan","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiovascular Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanglin","family":"Zhen","sequence":"additional","affiliation":[{"name":"Cardiovascular Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/14228\/11168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v33i4.14228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:31:43Z","timestamp":1741890703000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v33i4.14228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8,1]]}},"alternative-id":["10.25011\/cim.v33i4.14228"],"URL":"https:\/\/doi.org\/10.25011\/cim.v33i4.14228","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2010,8,1]]}}}