{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:53:05Z","timestamp":1788191585038,"version":"build-2803163510"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2012,10,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Several novel genetic variants for type 2 diabetes mellitus (T2DM) have been identified through genome-wide association studies (GWAS). A case-controll study was performed to investigate the association of five new European or South Asian GWAS-derived susceptibility loci with T2DM in a Chinese population. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Five single nucleotide polymorphisms (SNPs) were genotyped: rs3923113 near GRB14, rs16861329 in ST6GAL1, rs1802295 in VPS26A, rs7178572 in HMG20A, and rs231362 near KCNQ1, by high-resolution melting (HRM) of small amplicons. The association between T2DM and related quantitative traits in a total of 900 Chinese individuals, including 498 type 2 diabetic patients and 402 ethnically matched control subjects, were examined. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> After adjusting for age and gender, rs1802295 (OR 5.724, P=0.03) and rs231362 (OR=5.683, P=0.016) were found to be associated with T2DM. Triglyceride levels were higher in TT and CT carriers for rs16861329 (1.05 (0.8-1.34) mmol\/l) than in CC carriers (0.91 (0.73-1.23) mmol\/l) with P=0.008 and that high-density lipoprotein cholesterol (HDL-C) was lower in TT and CT carriers (1.17 (1.02-1.33) mmol\/l) than in CC carriers (1.21 (1.05-1.41) mmol\/l), with P=0.034. For rs3923113, the HDL-C levels were lower in the GG carriers (1.08 (0.90-1.18) mmol\/l) than in the GT+TT carriers (1.21 (1.04-1.38) mmol\/l), with P=0.018. Ours is the first report of this association. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> rs231362-KCNQ1 and rs1802295-VPS26A are associated with T2DM in the Chinese population. The remaining three SNPs are associated with other aspects of lipid metabolism. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v35i5.18706","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:16:05Z","timestamp":1493766965000},"page":"E327-E333","source":"Crossref","is-referenced-by-count":16,"title":["Genome-Wide Association Studies-derived susceptibility loci in Type 2 Diabetes: confirmation in a Chinese population"],"prefix":"10.3138","volume":"35","author":[{"given":"Shuangyan","family":"Lu","sequence":"first","affiliation":[{"name":"Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jianghan University, Hubei, Wuhan 430056, P.R.China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Lv","sequence":"additional","affiliation":[{"name":"Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/18706\/15649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v35i5.18706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:35:27Z","timestamp":1741890927000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v35i5.18706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,6]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10,6]]}},"alternative-id":["10.25011\/cim.v35i5.18706"],"URL":"https:\/\/doi.org\/10.25011\/cim.v35i5.18706","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,6]]}}}