{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:54:30Z","timestamp":1778910870608,"version":"3.51.4"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The purpose of this study was to evaluate the relationship between apolipoprotein A-IV (apoA-IV) plasma concentrations and acute coronary syndrome (ACS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Plasma apoA-IV concentrations were measured in 115 patients with different types of ACS and in 68 gender- and age-matched control subjects using Enzyme-Linked Immunosorbent Assay (ELISA) kits. The clinical data were collected by an internist, who was blinded to plasma apoA-IV concentrations. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Plasma apoA-IV levels in ACS patients were significantly decreased compared to the levels in control subjects (437.0 \u00b1 157.5 \u03bcg\/mL vs. 590.2 \u00b1 183.7 \u03bcg\/mL, P &lt; 0.001). An statistically significant decreasing trend of plasma apoA-IV levels from the control subjects, to patients with unstable angina pectoris (UAP) (457.3 \u00b1 152.9 \u03bcg\/mL), to patients with acute myocardial infarction (AMI) (311.7 \u00b1 127.8 \u03bcg\/mL), was observed. Moreover, plasma apoA-IV level was negatively associated with New York Heart Association (NYHA) functional class. NYHA class II (467.2 \u00b1 142.1 \u03bcg\/mL, P &lt; 0.001) and class III\/IV (368.1 \u00b1 170.8 \u03bcg\/mL, P &lt; 0.001) patients had statistically decreased levels of plasma apoA-IV when compared to the control subjects. A stepwise multivariate regression analysis identified types of ACS, NYHA classes, and plasma fibrinogen levels as the most important determinants of plasma apoA-IV levels in ACS patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Low plasma apoA-IV levels are associated with ACS, and plasma apoA-IV levels may be a potential treatment target for ACS patients. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v36i4.19954","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:04:10Z","timestamp":1493766250000},"page":"E207-E215","source":"Crossref","is-referenced-by-count":9,"title":["Decreased plasma apolipoprotein AIV levels in patients with acute coronary syndrome"],"prefix":"10.3138","volume":"36","author":[{"given":"Jiabei","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingbao","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehui","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oncology, the Second Affliated Hospital, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/19954\/16476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v36i4.19954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:09:52Z","timestamp":1741889392000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v36i4.19954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8,1]]}},"alternative-id":["10.25011\/cim.v36i4.19954"],"URL":"https:\/\/doi.org\/10.25011\/cim.v36i4.19954","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,1]]}}}