{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:19:11Z","timestamp":1790054351591,"version":"4.0.1"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The purpose of this study was to investigate the levels of interleukin-33 (IL-33) and interleukin-6 (IL-6) in patients with acute coronary syndrome or stable angina. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Serum IL-33 and IL-6 were measured with Enzyme Linked Immuosorbent Assay (ELISA) in patients with acute coronary syndrome (ACS, n = 40), and stable angina pectoris (SAP, n = 43). IL-33 and IL-6 were also determined in 30 healthy subjects (control group). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The serum level of IL-33 in the ACS group (78.60 \u00b1 44.84 ng\/L) was lower than in the SAP (102.58 \u00b1 37.21 ng\/L, P &lt; 0.01) or control groups (130.24 \u00b1 10.17 ng\/L, P &lt; 0.01). The serum level of IL-6 in the ACS group (39.90 \u00b1 12.64 ng\/L) was higher than in the SAP (18.68 \u00b1 11.89 ng\/L, P &lt; 0.05) or control groups (6.28 \u00b1 17.72 ng\/L, P &lt; 0.05). There were no differences in serum levels of IL-33 and IL-6 among the single-, double- and triple-vessel lesion groups. IL-33 and IL-6 levels were negatively correlated with each other in the ACS (r = -0.871, P &lt; 0.01) and SAP groups (r = -0.788, P &lt; 0.01). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The serum level of IL-33 was lower in patients with ACS or SAP and was negatively correlated with the serum level of IL-6. Thus, IL-33 and IL-6 may be used as biomarkers for evaluating inflammatory response and severity of coronary heart disease in patients with ACS or SAP. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v36i4.19957","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:04:10Z","timestamp":1493766250000},"page":"E234-E241","source":"Crossref","is-referenced-by-count":14,"title":["Levels of interleukin-33 and interleukin-6 in patients with acute coronary syndrome or stable angina"],"prefix":"10.3138","volume":"36","author":[{"given":"Cong-Lin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, the First Affliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."},{"name":"Institute of Clinical Medicine, The First Affliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Liang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui-","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Nan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Min","family":"Hai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/19957\/16479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v36i4.19957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:09:56Z","timestamp":1741889396000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v36i4.19957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8,1]]}},"alternative-id":["10.25011\/cim.v36i4.19957"],"URL":"https:\/\/doi.org\/10.25011\/cim.v36i4.19957","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,1]]}}}