{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:44:36Z","timestamp":1760784276731,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance of body mass index (BMI) in hormone receptor-positive, operable breast cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> In this retrospective cohort study, 1,192 consecutive patients with curative resection of primary breast cancer were enrolled. Patients were assigned to two groups according to BMI: normal or underweight (BMI &lt; 23.0 kg\/m2) and overweight or obese (BMI \u226523.0 kg\/m2). Associations among BMI and clinicopathological characteristics and prognosis of patients were assessed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> A high BMI was significantly (P &lt; 0.01) correlated with age, nodal stage, ALNR, ER positivity, PR positivity and menopausal status at diagnosis. Univariate analysis revealed that BMI, pathologic T stage, nodal stage, axillary lymph node ratio (ALNR) and adjuvant radiotherapy history were significantly (P &lt; 0.05) associated with disease-free survival and overall survival, irrespective of tumour hormone receptor status. Multivariate analysis revealed BMI as an independent prognostic factor in all cases and in hormone receptor-positive cases. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> A high BMI (\u226523.0 kg\/m^2) is independently associated with poor prognosis in hormone receptor-positive breast cancer. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v36i6.20627","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:01:48Z","timestamp":1493766108000},"page":"E297-E305","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery"],"prefix":"10.3138","volume":"36","author":[{"given":"Peng","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Guang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ting","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Lin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/20627\/16953","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v36i6.20627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:27:34Z","timestamp":1741890454000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v36i6.20627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12,1]]}},"alternative-id":["10.25011\/cim.v36i6.20627"],"URL":"https:\/\/doi.org\/10.25011\/cim.v36i6.20627","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2013,12,1]]}}}