{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:47:25Z","timestamp":1790981245244,"version":"4.1.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The purpose of this study was to investigate the effect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. The hearing of each participant was tested with pure tone audiometry and transient evoked autoacoustic emissions before and two and four weeks after treatment with isotretinoin (0.3-0.6 mg\/kg\/day) in the remaining 31 patients (62 ears). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The differences between the mean values of the pre-treatment and post-treatment pure tone hearing thresholds at 1000, 2000, 4000 and 6000 Hz frequencies were statistically significant (p &lt; 0.05), but there was no significant difference between the pre-treatment and post-treatment values at 250 and 500 Hz frequencies (p &gt; 0.05). The difference between the pre-treatment and post-treatment signal\u2014noise ratio values of the transient evoked autoacoustic emissions was not significantly different (p &gt; 0.05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Our results suggest that the use of isotretinoin may cause bilateral hearing threshold changes. Further animal and human studies are required to investigate and characterize isotretinoin-induced neurophysiological alterations in hearing. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v37i2.21092","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T12:50:36Z","timestamp":1493729436000},"page":"E102-E107","source":"Crossref","is-referenced-by-count":4,"title":["The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study"],"prefix":"10.3138","volume":"37","author":[{"given":"Mehmet","family":"Akdag","sequence":"first","affiliation":[{"name":"Assistant professor, Department of Otolaryngology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep M","family":"Akkurt","sequence":"additional","affiliation":[{"name":"Assistant professor, Department of Dermatology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Gul","sequence":"additional","affiliation":[{"name":"Assistant professor, Department of Otolaryngology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Ucmak","sequence":"additional","affiliation":[{"name":"Assistant professor, Department of Dermatology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyhan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Assistant professor, Department of Otolaryngology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Sengul","sequence":"additional","affiliation":[{"name":"Assistant professor, Department of Otolaryngology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Topcu","sequence":"additional","affiliation":[{"name":"Professor, Department of Otolaryngology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/21092\/17196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v37i2.21092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:23:43Z","timestamp":1741890223000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v37i2.21092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4,1]]}},"alternative-id":["10.25011\/cim.v37i2.21092"],"URL":"https:\/\/doi.org\/10.25011\/cim.v37i2.21092","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]}}}