{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:34:37Z","timestamp":1788813277837,"version":"build-2803163510"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Kidney Injury Molecule-1 is a protein that increases in urine following tubular damage. Kidney Injury Molecule-1 levels were correlated with the level of chronic kidney disease secondary to diabetic nephropathy in patients with type 2 Diabetes Mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and laboratory findings of 142 patients with diabetic nephropathy and 34 control subjects were analysed. Creatinine and HbA1c levels in blood samples and albumin, creatinine and Kidney Injury Molecule-1 levels in urine samples were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Urinary Kidney Injury Molecule-1 levels were significantly increased both in subgroups of diabetic nephropathy (normo-\/micro-\/macro-albuminuria) and in chronic kidney disease (stage 2-4) compared with controls. Urinary Kidney Injury Molecule-1 levels in stage 2 chronic kidney disease patients were significantly higher than those of the patients with stage 3-4 chronic kidney disease. Urinary Kidney Injury Molecule-1 levels, along with urinary albumin excretion and the duration of diabetes, were found to be independent risk factors associated with low glomerular filtration rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Urinary Kidney Injury Molecule-1 levels seems to predict renal injury secondary to diabetic nephropathy in early period independent of albuminuria, because urinary Kidney Injury Molecule-1 was elevated despite normal urinary albumin excretion in the normoalbuminuric subgroup. Urinary Kidney Injury Molecule-1 levels, which are elevated in primarily in stage 2, shows a gradual decrease in patients with chronic kidney disease stages 3 and 4; thus, urinary Kidney Injury Molecule-1 levels may be useful in tracking the progression of kidney disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25011\/cim.v37i6.22242","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T08:42:20Z","timestamp":1493714540000},"page":"E377-E383","source":"Crossref","is-referenced-by-count":39,"title":["Evaluation of the Urinary Kidney Injury Molecule-1 Levels in Patients With Diabetic Nephropathy"],"prefix":"10.3138","volume":"37","author":[{"given":"Buket Kin","family":"Tekce","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikmet","family":"Tekce","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulali","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sit","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/22242\/18061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v37i6.22242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T14:29:37Z","timestamp":1741876177000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v37i6.22242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12,1]]}},"alternative-id":["10.25011\/cim.v37i6.22242"],"URL":"https:\/\/doi.org\/10.25011\/cim.v37i6.22242","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}