{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:35:16Z","timestamp":1761676516533,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Drug-eluting stents (DES) in percutaneous coronary intervention are more effective in preventing in-stent restenosis compared with bare metal stents (BMS); however, DES may cause late stent thrombosis, which has limited its use. In this study, the functional properties of a newly developed DES (RAP\/CS\/HEP), in which rapamycin was abluminally-loaded onto a chitosan\/heparin coating stent (CS\/HEP), were investigated in large animal artery injury models. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> The effectiveness of BMS, RAP (the traditional version of rapamycin DES), CS\/HEP and RAP\/CS\/HEP stents in preventing coagulation and promoting re-endothelialisation was examined and compared in the porcine coronary artery models with arteriovenous shunt, high load thrombus and coronary balloon injury at day 7 and 28, respectively, after stent implantation. The re-endothelialisation on these stents was further evaluated in terms of endothelial gene expression using quantitative RT-PCR. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In the porcine coronary artery injury models, both RAP and RAP\/CS\/HEP stents were potent in reducing neointimal thickness, thus enlarging lumen area efficiently in the stented artery region compared with BMS and CS\/HEP. RAP\/CS\/HEP stents facilitated re-endothelialisation and inhibited thrombosis more efficiently than BMS and RAP. Consistent with this, the expression of endothelial genes, such as CD31, CD34, eNOS and VEGF, was significantly elevated with RAP\/CS\/HEP stents compared with RAP and BMS stents. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Abluminal coating of rapamycin onto the endothelialisation-accelerated CS\/HEP stent and may prove to be an efficient treatment for tackling the late stent thrombosis associated with the traditionally circumferential RAP stent. This new RAP\/CS\/HEP stent system exhibits considerably improved therapeutic activity. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v37i6.22244","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T12:42:20Z","timestamp":1493728940000},"page":"E395-E402","source":"Crossref","is-referenced-by-count":6,"title":["A new rapamycin-abluminally coated chitosan\/heparin stent system accelerates early re-endothelialisation and improves anti-coagulant properties in porcine coronary artery models"],"prefix":"10.3138","volume":"37","author":[{"given":"Junqing Q.","family":"Gao","sequence":"first","affiliation":[{"name":"Central Hospital of Shanghai Putuo District, 164 Lanxi Road, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianpu P.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Central Hospital of Shanghai Putuo District, 164 Lanxi Road, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huigen G.","family":"Jin","sequence":"additional","affiliation":[{"name":"Central Hospital of Shanghai Putuo District, 164 Lanxi Road, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenquan Q.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Hospital of Shanghai Putuo District, 164 Lanxi Road, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyong Y.","family":"Yan","sequence":"additional","affiliation":[{"name":"Central Hospital of Shanghai Putuo District, 164 Lanxi Road, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Central Hospital of Shanghai Putuo District, 164 Lanxi Road, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongjun J.","family":"Liu","sequence":"additional","affiliation":[{"name":"Central Hospital of Shanghai Putuo District, 164 Lanxi Road, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/22244\/18057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v37i6.22244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:29:39Z","timestamp":1741890579000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v37i6.22244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12,1]]}},"alternative-id":["10.25011\/cim.v37i6.22244"],"URL":"https:\/\/doi.org\/10.25011\/cim.v37i6.22244","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}