{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:40:10Z","timestamp":1792593610333,"version":"4.5.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2016,4,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Resveratrol has anti-infective, anti-inflammatory and antioxidant activities. The purpose of this study was to determine the effect of resveratrol in a rat experimental model of allergic rhinitis (AR). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Wistar albino rats were divided into three groups: control (n=7), AR with no treatment (AR+NoTr, n=7) and AR with resveratrol treatment (AR+Res, n=7). For AR+Res, AR was induced and resveratrol given on days 21-28. On day 28, the total blood IgE levels were measured. Allergic symptoms (sneezing, nose-rubbing, eye lacrimation and nasal congestion) were scored on a 0-3 point scale, and histopathological changes in the nasal mucosa were evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Allergic symptom score of AR+NoTr was higher than the other two groups and the score of AR+Res was higher than the control group. Histopathologically, neither ciliary loss nor chondrocyte hypertrophy differed among the three groups; however, vascular congestion, inflammatory and plasma cell numbers, eosinophil and mast cell infiltration and goblet cell numbers were higher and mast cell infiltration was more prominent in AR+NoTr than in AR+Res and control. AR+Res and control did not differ significantly in any histological parameter. In AR+NoTr, nasal mucosa exhibited ciliary loss, squamous epithelial metaplasia, inflammatory cell infiltration, vascular congestion of the lamina propria and goblet cell epithelial metaplasia. In AR+Res, goblet cell metaplasia was focal or absent and infiltration of the lamina propria by inflammatory cells, eosinophils, and plasma cells was reduced relative to AR+NoTr. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Allergic symptoms and tissue reactions were reduced by resveratrol treatment in rats with experimentally-induced AR. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v39i2.26482","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T11:32:34Z","timestamp":1493724754000},"page":"E63-E72","source":"Crossref","is-referenced-by-count":9,"title":["Is resveratrol therapeutic when used to treat allergic rhinitis in rats?"],"prefix":"10.3138","volume":"39","author":[{"given":"Kaz\u0131m","family":"Bozdemir","sequence":"first","affiliation":[{"name":"Assistant Professor in Yildirim Beyazit University, Faculty of Medicine, ENT Department, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethem","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Bayindir Icerenkoy Hospital, ENT Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyazi","family":"Altintoprak","sequence":"additional","affiliation":[{"name":"Tuzla State Hospital, ENT Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray B","family":"Muluk","sequence":"additional","affiliation":[{"name":"Professor in Kirikkale University, Medical Faculty, ENT Department, Kirikkale, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00fcl P","family":"Cengiz","sequence":"additional","affiliation":[{"name":"Yunus Emre State Hospital, Pathology Clinics, Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Acar","sequence":"additional","affiliation":[{"name":"Yunus Emre State Hospital, ENT Clinics, Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemal","family":"Cingi","sequence":"additional","affiliation":[{"name":"Professor in Eskisehir Osmangazi University, Medical Faculty, ENT Department, Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/26482\/19665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v39i2.26482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:36:40Z","timestamp":1741891000000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v39i2.26482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4,2]]}},"alternative-id":["10.25011\/cim.v39i2.26482"],"URL":"https:\/\/doi.org\/10.25011\/cim.v39i2.26482","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,2]]}}}