{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:57:10Z","timestamp":1776995830694,"version":"3.51.4"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2016,9,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Cardiovascular diseases are the main causes of morbidity and mortality in children with end-stage renal disease and the relationships among several relevant potential biomarkers were investigated in pediatric peritoneal dialysis patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Serum homocysteine, von Willebrand factor (vWF), apolipoproteins A and B, lipoprotein-a, high sensitive-CRP, hemoglobin, phosphorus and parathyroid hormone (PTH) levels, systolic (SBP) and diastolic (DBP) blood pressure, carotid intima-media thickness (cIMT) and left ventricular mass index (LVMI) were measured in 21 pediatric peritoneal dialysis patients and control subjects. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> All risk factors were higher in patients than controls. LVMI values were negatively correlated with hemoglobin and positively correlated with PTH and phosphorus levels (p=0.007, r= - 0.573; p=0.013, r= 0.532 and p=0.035, r= 0.461, respectively). cIMT was negatively associated with serum albumin and positively correlated with vWF levels and with SBP and DBP (p=0.006, r= - 0.578; p=0.039, r= 0.453; p=0.02, r= 0.503; p=0.024, r= 0.491, respectively). Robust regression analyses showed that hemoglobin was an independent predictor of LVMI and serum albumin was an independent predictor of cIMT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Only uremia-related factors were independent risk factors for predicting LVMI and cIMT. Hemoglobin level may be a critical factor in the development of left ventricular hypertrophy; therefore, effective treatment of anemia is crucial. Low serum albumin and high hsCRP and vWF levels, and their correlations with cIMT, indicate these patients could be at risk of developing malnutrition\u2014inflammation\u2014atherosclerosis syndrome and suggest that serum albumin and vWF levels may be useful markers for early detection of vascular damage. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v39i4.27090","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T11:32:34Z","timestamp":1493724754000},"page":"E111-E119","source":"Crossref","is-referenced-by-count":6,"title":["Serum albumin and von Willebrand factor: possible markers for early detection of vascular damage in children undergoing peritoneal dialysis"],"prefix":"10.3138","volume":"39","author":[{"given":"Nuran","family":"Cet\u0131n","sequence":"first","affiliation":[{"name":"Assistant Professor of Pediatric Nephrology Department of Pediatric Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadide M","family":"Sav","sequence":"additional","affiliation":[{"name":"Assistant Professor of Pediatric Nephrology Department of Pediatric Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duran","family":"Karabel","sequence":"additional","affiliation":[{"name":"Assistant Professor of Pediatric Cardiology Department of Pediatric Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Assistant Professor of Pediatric Cardiology Department of Pediatric Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Professor of Pediatric Nephrology Department of Pediatric Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/27090\/20080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v39i4.27090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:20:13Z","timestamp":1741890013000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v39i4.27090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,11]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,9,11]]}},"alternative-id":["10.25011\/cim.v39i4.27090"],"URL":"https:\/\/doi.org\/10.25011\/cim.v39i4.27090","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,11]]}}}