{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:45:45Z","timestamp":1778557545677,"version":"3.51.4"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2017,6,26]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The purpose of this study was to perform a meta-analysis comparing the rates of uterine rupture, and other maternal and neonatal complications, between women who undergo a trial of labour (TOL) after a prior Cesarean delivery and those to undergo elective repeat Cesarean delivery (ERCD). <\/jats:p><\/jats:sec><jats:sec><jats:title>Source<\/jats:title><jats:p> Medline, Cochrane, EMBASE and Google Scholar were searched until May 6, 2015 using the keywords\/phrases: trial of labour, Cesarean section, elective, repeat, pregnancy and vaginal birth. Randomized controlled trials (RCTs), two-arm prospective studies, one-arm studies and retrospective studies were included. The primary outcome was uterine rupture. <\/jats:p><\/jats:sec><jats:sec><jats:title>Principal findings<\/jats:title><jats:p> Sixteen studies were included in the meta-analysis. TOL after prior Cesarean delivery was associated with higher odds of uterine rupture as compared with ERCD (Peto odds ratio [OR] = 4.685, 95% confidence interval [CI]: 3.077 to 7.133, p &lt; 0.001). TOL was associated with a higher rate of endometritis, a lower rate of hysterectomy, and a lower rate of respiratory problems in newborns. There were no differences between the groups with respect to neonatal intensive care unit admissions, postpartum hemorrhage, thromboembolic disease, sepsis and neonatal mortality. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> TOL may be associated with a higher risk of uterine rupture and endometritis, but lower risk of hysterectomy and neonatal respiratory problems than ERCD. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v40i3.28393","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T09:08:33Z","timestamp":1498554513000},"page":"E135-E145","source":"Crossref","is-referenced-by-count":7,"title":["Maternal and neonatal morbidity: repeat Cesarean versus a trial of labour after previous Cesarean delivery"],"prefix":"10.3138","volume":"40","author":[{"given":"Yue-Zhou","family":"Yang","sequence":"first","affiliation":[{"name":"Shanghai Jiai Genetics and IVF Institute, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Ping","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Xi","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Jiai Genetics and IVF Institute, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cimonline.ca\/index.php\/cim\/article\/download\/28393\/20911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v40i3.28393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:15:10Z","timestamp":1741889710000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v40i3.28393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,26]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6,26]]}},"alternative-id":["10.25011\/cim.v40i3.28393"],"URL":"https:\/\/doi.org\/10.25011\/cim.v40i3.28393","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,26]]}}}