{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:37:21Z","timestamp":1789324641358,"version":"build-2803163510"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2021,10,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To investigate the therapeutic effects of minocycline combined with tinidazole in the treatment of chronic periodontitis (CP). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Seventy-three CP patients treated May 2018\u2013December 2019 at Yuyao People\u2019s Hospital (Yuyao, China) were enrolled in this study: 34 were treated with minocycline alone (control group; CG) and 39 were treated with a combination of minocycline and tinidazole (observation group; OG). Both groups were treated continuously for four weeks and plaque index (PLI), bleeding index (BI), periodontal pocket depth (PD), periodontal attachment level (PAL) and alveolar bone height were compared before and after treatment. Pain was evaluated using the visual analogue scale (VAS). Levels of TNF-\u03b1 and IL-6 before and after treatment were determined using an enzyme-linked immunosorbent assay. Adverse reactions were compared. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In each group, PLI, BI, PD, PAL and alveolar bone height were lower after treatment (P&lt;0.05), and those in OG were lower than those in CG (P&lt;0.05). TNF-\u03b1 and IL-6 levels in both groups were lower after treatment (P&lt;0.05), and the levels in serum of the OG were lower than those of the CG (P&lt;0.05). After treatment, the VAS in OG was lower than that of CG (P&lt;0.05). There was no significant difference in adverse reactions between groups (P&gt;0.05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Minocycline combined with tinidazole was more effective in treating CP than minocycline alone. This drug combination improved the periodontal indexes and inflammatory reaction of CP and relieved their pain. No significant difference in adverse reactions was seen. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v44i3.36477","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T14:53:23Z","timestamp":1634136803000},"page":"E25-E31","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Minocycline Combined with Tinidazole for Treatment of Chronic Periodontitis"],"prefix":"10.3138","volume":"44","author":[{"given":"Jiangjian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dentistry, Yuyao People\u2019s Hospital of Zhejiang Province, Yuyao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Dentistology, First Hospital of Ninghai County, Ninghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Yuyao People\u2019s Hospital of Zhejiang Province, Yuyao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cimonline.ca\/index.php\/cim\/article\/download\/36477\/28520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v44i3.36477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:20:41Z","timestamp":1741890041000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v44i3.36477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,10,3]]}},"alternative-id":["10.25011\/cim.v44i3.36477"],"URL":"https:\/\/doi.org\/10.25011\/cim.v44i3.36477","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,3]]}}}