{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:34:24Z","timestamp":1772552064840,"version":"3.50.1"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2021,12,31]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To evaluate the relationship between the serum calcitonin gene-related peptide (CGRP) level and severity of coronary stenosis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> A total of 233 eligible patients who underwent coronary angiography were divided into two groups: a control and a coronary heart disease (CHD) group. The angiographic severity of coronary stenosis was evaluated by SYNTAX and Gensini scores. The incidence of major adverse cardiovascular events within two years was collected. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> A negative correlation between serum CGRP levels and Gensini scores was observed in all patients (r=-0.352, p&lt;0.001), the control group (r=-0.422, p&lt;0.001) and the CHD group (r=-0.393, p&lt;0.001). Serum CGRP levels were negatively associated with SYNTAX scores in the CHD group (r=-0.522, p&lt;0.001). The area under the curve of CGRP for identifying high SYNTAX scores (&gt;22) was 0.772 [95% confidence interval (CI): 0.673-0.870, p&lt;0.001], and for identifying high Gensini scores was 0.744 (95% CI: 0.646-0.842, p&lt;0.001). A CGRP concentration of 25.05 pg\/ml was selected as the cutoff point. A low CGRP level (&lt;25.05 pg\/ml) was an independent predictor of severe coronary stenosis, a SYNTAX score &gt;22 [odds ratio (OR) =5.819, 95% CI: 2.240-15.116; p&lt;0.001] and a high Gensini score (&gt;64) (OR=4.943, 95% CI: 2.020-12.095; p&lt;0.001). The low CGRP group had a higher incidence of major adverse cardiovascular events within two years (11.1 vs. 3.1%, p=0.031). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> In coronary atherosclerosis patients without acute myocardial injury, serum CGRP levels were negatively associated with the severity of coronary stenosis. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v44i4.37593","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T18:31:13Z","timestamp":1640975473000},"page":"E23-E30","source":"Crossref","is-referenced-by-count":3,"title":["Low Serum Calcitonin Gene-Related Peptide Level is Associated with Severity of Coronary Stenosis"],"prefix":"10.3138","volume":"44","author":[{"given":"Xian-Feng","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Xin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Ming","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Fang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Kun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China"},{"name":"Department of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Key Laboratory of Vascular Aging (Fujian Medical University), Fuzhou, Fujian, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China"},{"name":"Department of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China"},{"name":"Fujian Key Laboratory of Vascular Aging (Fujian Medical University), Fuzhou, Fujian, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cimonline.ca\/index.php\/cim\/article\/download\/37593\/28875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v44i4.37593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:36:59Z","timestamp":1741891019000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v44i4.37593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12,31]]}},"alternative-id":["10.25011\/cim.v44i4.37593"],"URL":"https:\/\/doi.org\/10.25011\/cim.v44i4.37593","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,31]]}}}