{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:19:32Z","timestamp":1747210772934,"version":"3.40.5"},"reference-count":45,"publisher":"Universidad del Valle","issue":"1","content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>\r\nAim:\r\nWe aimed to evaluate the correlation between the polymorphism of the interleukin 1-Beta (IL1-\u03b2, +3954 C&gt;T) and tooth movement, in a group of Colombian patients undergoing surgically accelerated orthodontic tooth movement.\r\n\r\n\r\nMethods:\r\nThe study was nested to a controlled clinical trial. Blood samples were taken from 11 women and 29 healthy Colombian male volunteers between 18 and 40 years old, after 1 year of starting orthodontic treatment. The patients presented malocclusion class I, with grade II or III. To detect the genetic polymorphism of the nucleotide +3954 C to T in the IL-1\u03b2 gene, we used a real-time PCR assay.\r\n\r\n\r\nResults:\r\nEleven individuals presented the allele 2 (T) heterozygous with the allele 1 (T\/C) and 19 individuals were homozygous for the allele 1 (C\/C). When analyzing the presence of the SNP, no significant differences were found in any of the variables. The best treatment was reflected in Group 3 (selective upper and lower alveolar decortication and 3D collagen matrix) and Group 4 (only selective alveolar decortication in the upper arch, with 3D collagen matrix), with 27% and 35% more speed respectively than in the control group.\r\n\r\n\r\nConclusions:\r\nOur analyses indicated that a reduction in the total treatment time can be mostly potentiated by using decortication and collagen matrices and not for the presence of the allele 2 in the IL-1\u03b2. Nevertheless, it is important that further studies investigate if the polymorphism could be associated with the speed of tooth movement and analyze the baseline protein levels.\r\n<\/jats:p>","DOI":"10.25100\/cm.v51i1.4141","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T21:28:46Z","timestamp":1594934926000},"update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between the polymorphism in the interleukin 1-\u03b2 and the treatment time of patients subjected to a modified piezocision technique"],"prefix":"10.25100","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-7188","authenticated-orcid":false,"given":"Juan Fernando","family":"Aristizabal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Rios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4604-2460","authenticated-orcid":false,"given":"Diego","family":"Rey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-7428","authenticated-orcid":false,"given":"Maria Antonia","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-7449","authenticated-orcid":false,"given":"Beatriz","family":"Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-5165","authenticated-orcid":false,"given":"Mario","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10728","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"49212","doi-asserted-by":"crossref","unstructured":"Krishnan V, Davidovitch Z. 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