{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:22:51Z","timestamp":1790688171181,"version":"4.1.0"},"reference-count":29,"publisher":"Universidad del Valle","issue":"2","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>Background\r\nInborn errors of immunity, mainly Predominantly Antibody deficiencies with normal\u00a0IgG levels, are unrecognized in adults with lung diseases such as bronchiectasis or\u00a0recurrent pneumonia.\r\nObjective\r\nTo determine IgM, IgA, IgG2 subclass deficiencies, and Specific antibody deficiency\u00a0(anti-pneumococcal polysaccharide antibodies) in adults with non-cystic fibrosis\u00a0bronchiectasis or recurrent pneumonia.\r\nMethods\r\nCross-sectional study. Consecutive patients with non-cystic fibrosis bronchiectasis\u00a0or recurrent pneumonia were recruited in Cali, Colombia. IgG, IgA, IgM; IgE,\u00a0IgG2 subclass, and IgG anti-pneumococcal serum levels were measured.\r\nResults\r\nAmong the 110 participants enrolled, Antibody deficiencies with normal serum IgG\u00a0levels were found in 11(10%) cases. IgA deficiency (3 cases), IgM deficiency (2 cases), and IgG2 deficiency (2 cases) were the most frequent primary immunodeficiencies. In\u00a0addition, IgG2+IgA deficiency, Ataxia-telangiectasia, Hyper-IgE syndrome and Specific\u00a0Antibody Deficiency(anti-polysaccharides) were found in one case each.\r\nConclusions\r\nPredominantly antibody deficiencies with normal IgG levels are an important etiology of\u00a0non-cystic fibrosis bronchiectasis and recurrent pneumonia in adults.\r\n\u00a0<\/jats:p>","DOI":"10.25100\/cm.v53i2.4832","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T20:27:26Z","timestamp":1668112046000},"page":"e2014832","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Antibody deficiencies with normal IgG in adults with Non-cystic fibrosis bronchiectasis or recurrent pneumonia: Cross-sectional study"],"prefix":"10.25100","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-3677","authenticated-orcid":false,"given":"Andres F","family":"Zea-Vera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6736-3015","authenticated-orcid":false,"given":"Mario Alejandro","family":"Chac\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-7449","authenticated-orcid":false,"given":"Beatriz","family":"Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10728","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"55440","doi-asserted-by":"crossref","unstructured":"Mahlaoui N, Warnatz K, Jones A, Workman S, Cant A. Advances in the care of primary immunodeficiencies (PIDs): from birth to adulthood. J Clin Immunol. 2017; 37(5): 452-60. https:\/\/doi.org\/10.1007\/s10875-017-0401-y","DOI":"10.1007\/s10875-017-0401-y"},{"key":"55441","doi-asserted-by":"crossref","unstructured":"McCusker C, Upton J, Warrington R. Primary immunodeficiency. Allergy Asthma Clin Immunol. 2018; 14(S2): 61. https:\/\/doi.org\/10.1186\/s13223-018-0290-5","DOI":"10.1186\/s13223-018-0290-5"},{"key":"55442","doi-asserted-by":"crossref","unstructured":"Tangye SG, Al-Herz W, Bousfiha A, Chatila T, Cunningham-Rundles C, Etzioni A, et al. Human inborn errors of immunity: 2019 update on the classification from the international union of immunological societies expert committee. J Clin Immunol. 2020; 40(1): 24-64. https:\/\/doi.org\/10.1007\/s10875-019-00737-x","DOI":"10.1007\/s10875-019-00737-x"},{"key":"55443","doi-asserted-by":"crossref","unstructured":"Slade CA, Bosco JJ, Giang TB, Kruse E, Stirling RG, Cameron PU, et al. 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