{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:19:42Z","timestamp":1747210782625,"version":"3.40.5"},"reference-count":0,"publisher":"Universidad del Valle","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>Case description:A 22-year-old female patient received the first dose of Pfizer-BioNTech vaccine\u00a0(RNAm) against COVID-19; 6 days later, she presented abdominal pain located in\u00a0the right hypochondrium and epigastrium, associated with emetic episodes. Consultation\u00a021 days later due to the same symptoms; three days after the seconddose of the vaccine was administered.\u00a0\r\nClinical findings:Pain on palpation in the right hypochondrium. Laboratories reported hepatocellular\u00a0lesions and cholestasis, with negative amylase, hepatotropic virus and autoimmune\u00a0hepatitis tests. Liver and biliary tract ultrasound and cholangioresonance were normal.\r\nTreatment and Results:Hyoscine and intravenous fluids as support therapy. She presented improvement\u00a0in abdominal pain and a progressive decrease of transaminases and bilirubin levels\u00a0until normalization and was discharged on the fifth day of hospitalization. A drug-associated\u00a0hepatotoxicity (DILI) diagnosis was considered probable, in this case,\u00a0secondary to vaccination against COVID-19.\u00a0\r\nClinical Relevance:The current SARS-CoV-2 pandemic has spurred the development of new vaccines, the\u00a0safety of which remains a concern. There is a likely causal relationship between vaccination\u00a0and liver involvement in this clinical case rather than simply a sporadic occurrence.<\/jats:p>","DOI":"10.25100\/cm.v53i3.5187","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T21:33:17Z","timestamp":1667424797000},"page":"e5015187","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Drug-induced liver injury after covid-19 mRNA vaccine: case report"],"prefix":"10.25100","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1061-309X","authenticated-orcid":false,"given":"Ayleen","family":"Rivera-Tenorio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-8293","authenticated-orcid":false,"given":"Hector","family":"Hern\u00e1ndez-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-4280","authenticated-orcid":false,"given":"Pablo Andr\u00e9s","family":"Triana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-5285","authenticated-orcid":false,"given":"Juliana","family":"Guti\u00e9rrez- Posso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-8285","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Osorio-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7557-8550","authenticated-orcid":false,"given":"Julio Ernesto","family":"Saez Velandia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7292-5868","authenticated-orcid":false,"given":"William","family":"Salazar Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-9400","authenticated-orcid":false,"given":"Jose Dar\u00edo","family":"Portillo-Mi\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10728","published-online":{"date-parts":[[2022,9,1]]},"container-title":["Colombia Medica"],"original-title":[],"link":[{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5187\/5976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5187\/5978","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5187\/5977","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5187\/5975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T17:59:01Z","timestamp":1722967141000},"score":1,"resource":{"primary":{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/view\/5187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.25100\/cm.v53i3.5187","relation":{},"ISSN":["1657-9534","0120-8322"],"issn-type":[{"type":"electronic","value":"1657-9534"},{"type":"print","value":"0120-8322"}],"subject":[],"published":{"date-parts":[[2022,9,1]]},"assertion":[{"value":"Yes","name":"crosschecked","label":"CrossChecked"},{"value":"Yes","name":"peer_reviewed","label":"Peer Reviewed"}]}}