{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:19:44Z","timestamp":1747210784271,"version":"3.40.5"},"reference-count":39,"publisher":"Universidad del Valle","issue":"3","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>Background: Amyloid light chain (AL) amyloidosis is characterized by amyloid fibril deposition derived from monoclonal immunoglobulin light chains, resulting in multiorgan dysfunction. Limited data exist on the clinical features of AL amyloidosis.\nObjective: This study aims to describe the clinical characteristics, treatments, and outcomes in Colombian patients with AL amyloidosis.\nMethods: A retrospective descriptive study was conducted at three high-complexity centers in Medell\u00edn, Colombia. Adults with AL amyloidosis diagnosed between 2012 and 2022 were included. Clinical, laboratory, histological, treatment, and survival data were analyzed.\nResults: The study included 63 patients. Renal involvement was most prevalent (66%), followed by cardiac involvement (61%). Multiorgan involvement occurred in 61% of patients. Amyloid deposition was most commonly detected in renal biopsy (40%). Bortezomib-based therapy was used in 68%, and 23.8% received high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HDCT-ASCT). Hematological response was observed in 95% of patients with available data. Cardiac and renal organ responses were 15% and 14%, respectively. Median overall survival was 45.1 months (95% CI: 22.2-63.8).\nIn multivariate analysis, cardiac involvement was significantly associated with inferior overall survival (HR 3.27; 95% CI: 1.23-8.73; p=0.018), HDCT-ASCT had a non-significant trend towards improved overall survival (HR 0.25; 95% CI: 0.06-1.09; p=0.065).\nConclusions: In this study of Colombian patients with AL amyloidosis, renal involvement was more frequent than cardiac involvement. Overall survival and multiorgan involvement were consistent with data from other regions of the world. Multivariate analysis identifiedcardiac involvement and HDCT-AHCT as possible prognostic factors.<\/jats:p>","DOI":"10.25100\/cm.v54i3.5667","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T18:33:20Z","timestamp":1701455600000},"page":"e2025667","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characterization and outcomes of a cohort of colombian patients with AL Amyloidosis"],"prefix":"10.25100","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-5807","authenticated-orcid":false,"given":"Jorge Andr\u00e9s","family":"Lacouture Fierro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-4599","authenticated-orcid":false,"given":"Daniel Andr\u00e9s","family":"Ribero Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0133-4088","authenticated-orcid":false,"given":"Juanita","family":"S\u00e1nchez Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-6971","authenticated-orcid":false,"given":"Lina Maria","family":"Gaviria Jaramillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-7253","authenticated-orcid":false,"given":"Oliver Gerardo","family":"Perilla Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1192-9053","authenticated-orcid":false,"given":"Kenny Mauricio","family":"Galvez C\u00e1rdenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1192-9053","authenticated-orcid":false,"given":"Sigifredo","family":"Ospina Ospina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10728","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"62312","doi-asserted-by":"crossref","unstructured":"Dasari S, Theis JD, Vrana JA, Rech KL, Dao LN, Howard MT, et al. Amyloid Typing by Mass Spectrometry in Clinical Practice: a Comprehensive Review of 16,175 Samples. Mayo Clin Proc. 2020 Sep;95(9):1852-64. https:\/\/doi.org\/10.1016\/j.mayocp.2020.06.029 PMid:32861330","DOI":"10.1016\/j.mayocp.2020.06.029"},{"key":"62313","doi-asserted-by":"crossref","unstructured":"Gertz MA. Immunoglobulin light chain amyloidosis: 2022 update on diagnosis, prognosis, and treatment. Am J Hematol. 2022 Jun 1;97(6):818-29. https:\/\/doi.org\/10.1002\/ajh.26569 PMid:35429180","DOI":"10.1002\/ajh.26569"},{"key":"62314","doi-asserted-by":"crossref","unstructured":"Merlini G, Bellotti V. Molecular Mechanisms of Amyloidosis. New England Journal of Medicine. 2003 Aug 7;349(6):583-96. https:\/\/doi.org\/10.1056\/NEJMra023144 PMid:12904524","DOI":"10.1056\/NEJMra023144"},{"key":"62315","doi-asserted-by":"crossref","unstructured":"Merlini G. AL amyloidosis: from molecular mechanisms to targeted therapies. Hematology. 2017 Dec 8;2017(1):1-12. https:\/\/doi.org\/10.1182\/asheducation-2017.1.1 PMid:29222231 PMCid:PMC6142527","DOI":"10.1182\/asheducation-2017.1.1"},{"key":"62316","doi-asserted-by":"crossref","unstructured":"Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, et al. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2014 Nov;6(11):1493-507. https:\/\/doi.org\/10.15252\/emmm.201404190 PMid:25319546 PMCid:PMC4237473","DOI":"10.15252\/emmm.201404190"},{"key":"62317","doi-asserted-by":"crossref","unstructured":"Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 2016 Jun;8(6):595-608. https:\/\/doi.org\/10.15252\/emmm.201606210 PMid:27025652 PMCid:PMC4888851","DOI":"10.15252\/emmm.201606210"},{"key":"62318","doi-asserted-by":"crossref","unstructured":"Vaxman I, Dispenzieri A, Muchtar E, Gertz M. New developments in diagnosis, risk assessment and management in systemic amyloidosis. Blood Rev. 2020 Mar 1;40. https:\/\/doi.org\/10.1016\/j.blre.2019.100636 PMid:31706583 PMCid:PMC7124973","DOI":"10.1016\/j.blre.2019.100636"},{"key":"62319","doi-asserted-by":"crossref","unstructured":"Quock TP, Yan T, Chang E, Guthrie S, Broder MS. Epidemiology of AL amyloidosis: a real-world study using US claims data. Blood Adv. 2018 May 22;2(10):1046-53. https:\/\/doi.org\/10.1182\/bloodadvances.2018016402 PMid:29748430 PMCid:PMC5965052","DOI":"10.1182\/bloodadvances.2018016402"},{"key":"62320","doi-asserted-by":"crossref","unstructured":"Kyle RA, Larson DR, Kurtin PJ, Kumar S, Cerhan JR, Therneau TM, et al. Incidence of AL Amyloidosis in Olmsted County, Minnesota, 1990 through 2015. Mayo Clin Proc. 2019 Mar;94(3):465-71. https:\/\/doi.org\/10.1016\/j.mayocp.2018.08.041 PMid:30713046 PMCid:PMC6401262","DOI":"10.1016\/j.mayocp.2018.08.041"},{"key":"62321","doi-asserted-by":"crossref","unstructured":"Kyle RA, Linos A, Beard CM, Linke RP, Gertz MA, O'Fallon WM, et al. Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood. 1992 Apr 1;79(7):1817-22. https:\/\/doi.org\/10.1182\/blood.V79.7.1817.bloodjournal7971817 PMid:1558973","DOI":"10.1182\/blood.V79.7.1817.1817"},{"key":"62322","doi-asserted-by":"crossref","unstructured":"Wisniowski B, McLeod DSA, Adams R, Harvey Y, Brown I, McGuire L, et al. The epidemiology of amyloidosis in Queensland, Australia. Br J Haematol. 2019 Sep;186(6):829-36. https:\/\/doi.org\/10.1111\/bjh.16000 PMid:31148162","DOI":"10.1111\/bjh.16000"},{"key":"62323","doi-asserted-by":"crossref","unstructured":"Pinney JH, Smith CJ, Taube JB, Lachmann HJ, Venner CP, Gibbs SDJ, et al. Systemic amyloidosis in England: an epidemiological study. Br J Haematol. 2013 May;161(4):525-32. https:\/\/doi.org\/10.1111\/bjh.12286 PMid:23480608 PMCid:PMC4296340","DOI":"10.1111\/bjh.12286"},{"key":"62324","unstructured":"Duhamel S, Mohty D, Magne J, Lavergne D, Bordessoule D, Aboyans V, et al. Incidence and Prevalence of Light Chain Amyloidosis: A Population-Based Study. Blood [Internet]. 2017 Dec 7 [cited 2023 Mar 9];130(Supplement 1):5577-5577. Available from: https:\/\/ashpublications.org\/blood\/article\/130\/Supplement 1\/5577\/115744\/Incidence-and-Prevalence-of-Light-Chain. https:\/\/doi.org\/10.1182\/blood.V130.Suppl_1.5577.5577"},{"key":"62325","doi-asserted-by":"crossref","unstructured":"Kumar N, Zhang NJ, Cherepanov D, Romanus D, Hughes M, Faller D V. Global epidemiology of amyloid light-chain amyloidosis. Orphanet J Rare Dis. 2022 Dec 19;17(1):278. https:\/\/doi.org\/10.1186\/s13023-022-02414-6 PMid:35854312 PMCid:PMC9295439","DOI":"10.1186\/s13023-022-02414-6"},{"key":"62326","doi-asserted-by":"crossref","unstructured":"Hasib Sidiqi M, Gertz MA. Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021. Blood Cancer J. 2021 May 15;11(5):90. https:\/\/doi.org\/10.1038\/s41408-021-00483-7 PMid:33993188 PMCid:PMC8124067","DOI":"10.1038\/s41408-021-00483-7"},{"key":"62327","doi-asserted-by":"crossref","unstructured":"Palladini G, Milani P, Merlini G. Novel strategies for the diagnosis and treatment of cardiac amyloidosis. Expert Rev Cardiovasc Ther. 2015 Nov;13(11):1195-211. https:\/\/doi.org\/10.1586\/14779072.2015.1093936 PMid:26496239","DOI":"10.1586\/14779072.2015.1093936"},{"key":"62328","doi-asserted-by":"crossref","unstructured":"Palladini G, Sch\u00f6nland S, Merlini G, Milani P, Jaccard A, Bridoux F, et al. The management of light chain (AL) amyloidosis in Europe: clinical characteristics, treatment patterns, and efficacy outcomes between 2004 and 2018. Blood Cancer J. 2023 Jan 25;13(1):19. https:\/\/doi.org\/10.1038\/s41408-023-00789-8 PMid:36697388 PMCid:PMC9876983","DOI":"10.1038\/s41408-023-00789-8"},{"key":"62329","doi-asserted-by":"crossref","unstructured":"Palladini G, Sachchithanantham S, Milani P, Gillmore J, Foli A, Lachmann H, et al. A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis. Blood. 2015 Jul 30;126(5):612-5.https:\/\/doi.org\/10.1182\/blood-2015-01-620302 PMid:25987656","DOI":"10.1182\/blood-2015-01-620302"},{"key":"62330","doi-asserted-by":"crossref","unstructured":"Kastritis E, Leleu X, Arnulf B, Zamagni E, Cibeira MT, Kwok F, et al. Bortezomib, Melphalan, and Dexamethasone for Light-Chain Amyloidosis. J Clin Oncol. 2020 Oct 1;38(28):3252-60.https:\/\/doi.org\/10.1200\/JCO.20.01285 PMid:32730181","DOI":"10.1200\/JCO.20.01285"},{"key":"62331","doi-asserted-by":"crossref","unstructured":"Gertz MA, Lacy MQ, Dispenzieri A, Buadi FK, Dingli D, Hayman SR, et al. Stem cell transplantation compared with melphalan plus dexamethasone in the treatment of immunoglobulin light-chain amyloidosis. Cancer. 2016 Jul 15;122(14):2197-205. https:\/\/doi.org\/10.1002\/cncr.30051 PMid:27142462 PMCid:PMC4930380","DOI":"10.1002\/cncr.30051"},{"key":"62332","unstructured":"Kastritis E, Palladini G, Minnema MC, Wechalekar AD, Jaccard A, Lee HC, et al. Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis. N Engl J Med. 2021 Jul 1;385(1):46-58. https:\/\/doi\/10.1056\/NEJMoa2028631"},{"key":"62333","doi-asserted-by":"crossref","unstructured":"Sidana S, Tandon N, Gertz MA, Dispenzieri A, Ramirez-Alvarado M, Murray DL, et al. Clinical features, laboratory characteristics and outcomes of patients with renal versus cardiac light chain amyloidosis. Br J Haematol. 2019 May;185(4):701-7.https:\/\/doi.org\/10.1111\/bjh.15832 PMid:30836444","DOI":"10.1111\/bjh.15832"},{"key":"62334","doi-asserted-by":"crossref","unstructured":"Muchtar E, Dispenzieri A, Wisniowski B, Palladini G, Milani P, Merlini G, et al. Graded Cardiac Response Criteria for Patients With Systemic Light Chain Amyloidosis. J Clin Oncol. 2023 Mar 1;41(7):1393-403. https:\/\/doi.org\/10.1200\/JCO.22.00643 PMid:36215675","DOI":"10.1200\/JCO.22.00643"},{"key":"62335","doi-asserted-by":"crossref","unstructured":"Kourelis T V, Kumar SK, Gertz MA, Lacy MQ, Buadi FK, Hayman SR, et al. Coexistent multiple myeloma or increased bone marrow plasma cells define equally high-risk populations in patients with immunoglobulin light chain amyloidosis. J Clin Oncol. 2013 Dec 1;31(34):4319-24. https:\/\/doi.org\/10.1200\/JCO.2013.50.8499 PMid:24145344 PMCid:PMC4881366","DOI":"10.1200\/JCO.2013.50.8499"},{"key":"62336","doi-asserted-by":"crossref","unstructured":"Vaxman I, Sidiqi MH, Al Saleh AS, Kumar S, Muchtar E, Dispenzieri A, et al. Depth of response prior to autologous stem cell transplantation predicts survival in light chain amyloidosis. Bone Marrow Transplant. 2021 Apr;56(4):928-35. https:\/\/doi.org\/10.1038\/s41409-020-01136-2 PMid:33208916","DOI":"10.1038\/s41409-020-01136-2"},{"key":"62337","doi-asserted-by":"crossref","unstructured":"Gertz MA, Comenzo R, Falk RH, Fermand JP, Hazenberg BP, Hawkins PN, et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis. Am J Hematol. 2005 Aug;79(4):319-28. https:\/\/doi.org\/10.1002\/ajh.20381 PMid:16044444","DOI":"10.1002\/ajh.20381"},{"key":"62338","doi-asserted-by":"crossref","unstructured":"Comenzo RL, Reece D, Palladini G, Seldin D, Sanchorawala V, Landau H, et al. Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis. Leukemia. 2012 Nov 5;26(11):2317-25. https:\/\/doi.org\/10.1038\/leu.2012.100 PMid:22475872","DOI":"10.1038\/leu.2012.100"},{"key":"62339","doi-asserted-by":"crossref","unstructured":"Posadas-Martinez ML, Aguirre MA, Brulc E, Saez MS, Sorroche P, Machnicki G, et al. Treatment patterns and outcomes in light chain amyloidosis: An institutional registry of amyloidosis report in Argentina. PLoS One. 2022 Oct 27;17(10):e0274578. https:\/\/doi.org\/10.1371\/journal.pone.0274578 PMid:36301970 PMCid:PMC9612475","DOI":"10.1371\/journal.pone.0274578"},{"key":"62340","doi-asserted-by":"crossref","unstructured":"Pe\u00f1a C, Gonz\u00e1lez JT, L\u00f3pez-Vidal H, Donoso J, Contreras C, Vergara CG, et al. AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group. Rev Med Chil. 2019 Oct;147(10):1239-46. https:\/\/doi.org\/10.4067\/s0034-98872019001001239 PMid:32186631","DOI":"10.4067\/s0034-98872019001001239"},{"key":"62341","doi-asserted-by":"crossref","unstructured":"Michael M, Kastritis E, Delimpassi S, Michalis E, Repoussis P, Kyrtsonis MC, et al. Clinical Characteristics and Outcome of Primary Systemic Light-Chain Amyloidosis in Greece. Clin Lymphoma Myeloma Leuk. 2010 Feb;10(1):56-61. https:\/\/doi.org\/10.3816\/CLML.2010.n.006 PMid:20223730","DOI":"10.3816\/CLML.2010.n.006"},{"key":"62342","doi-asserted-by":"crossref","unstructured":"He D, Guan F, Hu M, Zheng G, He J, Han X, et al. The Clinical Characteristics and Prognosis of Chinese Patients with Light-Chain Amyloidosis: A Retrospective Multicenter Analysis. Indian Journal of Hematology and Blood Transfusion. 2022 Jul 28;38(3):444-53. https:\/\/doi.org\/10.1007\/s12288-021-01469-y PMid:35747578 PMCid:PMC9209627","DOI":"10.1007\/s12288-021-01469-y"},{"key":"62343","doi-asserted-by":"crossref","unstructured":"Muchtar E, Gertz MA, Kyle RA, Lacy MQ, Dingli D, Leung N, et al. A Modern Primer on Light Chain Amyloidosis in 592 Patients With Mass Spectrometry-Verified Typing. Mayo Clin Proc. 2019 Feb; https:\/\/doi.org\/10.1016\/j.mayocp.2018.08.006","DOI":"10.1016\/j.mayocp.2018.08.006"},{"key":"62344","doi-asserted-by":"crossref","unstructured":"Zhao Q, Li F, Song P, Zhou X, Wang L, Yu Y, et al. Clinical Characteristics and Treatment Outcome of Chinese Patients With Systemic Amyloid Light-Chain Amyloidosis: A Retrospective Single-Center Analysis. Clin Lymphoma Myeloma Leuk. 2016 Feb;16(2):104-10. https:\/\/doi.org\/10.1016\/j.clml.2015.11.001 PMid:26752455","DOI":"10.1016\/j.clml.2015.11.001"},{"key":"62345","doi-asserted-by":"crossref","unstructured":"Lilleness B, Ruberg FL, Mussinelli R, Doros G, Sanchorawala V. Development and validation of a survival staging system incorporating BNP in patients with light chain amyloidosis. Blood. 2019 Jan 17;133(3):215-23. https:\/\/doi.org\/10.1182\/blood-2018-06-858951 PMid:30333122","DOI":"10.1182\/blood-2018-06-858951"},{"key":"62346","doi-asserted-by":"crossref","unstructured":"Palladini G, Milani P, Merlini G. Predicting survival in light chain amyloidosis. Haematologica. 2019 Jul 30;104(7):1294-6. https:\/\/doi.org\/10.3324\/haematol.2019.218859 PMid:31257205 PMCid:PMC6601088","DOI":"10.3324\/haematol.2019.218859"},{"key":"62347","doi-asserted-by":"crossref","unstructured":"Kumar S, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, Colby C, et al. Revised Prognostic Staging System for Light Chain Amyloidosis Incorporating Cardiac Biomarkers and Serum Free Light Chain Measurements. Journal of Clinical Oncology. 2012 Mar 20;30(9):989-95. https:\/\/doi.org\/10.1200\/JCO.2011.38.5724 PMid:22331953 PMCid:PMC3675680","DOI":"10.1200\/JCO.2011.38.5724"},{"key":"62348","doi-asserted-by":"crossref","unstructured":"Gillmore JD, Wechalekar A, Bird J, Cavenagh J, Hawkins S, Kazmi M, et al. Guidelines on the diagnosis and investigation of AL amyloidosis. Br J Haematol. 2015 Jan;168(2):207-18. https:\/\/doi.org\/10.1111\/bjh.13156 PMid:25312307","DOI":"10.1111\/bjh.13156"},{"key":"62349","doi-asserted-by":"crossref","unstructured":"Foli A, Palladini G, Caporali R, Verga L, Morbini P, Obici L, et al. The role of minor salivary gland biopsy in the diagnosis of systemic amyloidosis: results of a prospective study in 62 patients. Amyloid. 2011 Jun 18;18(sup1):80-2. https:\/\/doi.org\/10.3109\/13506129.2011.574354029 PMid:21838441","DOI":"10.3109\/13506129.2011.574354029"},{"key":"62350","doi-asserted-by":"crossref","unstructured":"Basset M, Milani P, Nuvolone M, Benigna F, Rodigari L, Foli A, et al. Sequential response-driven bortezomib-based therapy followed by autologous stem cell transplant in AL amyloidosis. Blood Adv. 2020 Sep 8;4(17):4175-9. https:\/\/doi.org\/10.1182\/bloodadvances.2020002219 PMid:32886751 PMCid:PMC7479942","DOI":"10.1182\/bloodadvances.2020002219"}],"container-title":["Colombia Medica"],"original-title":[],"link":[{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5667\/5741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5667\/5742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5667\/5743","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5667\/5744","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5667\/5741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T17:59:03Z","timestamp":1722967143000},"score":1,"resource":{"primary":{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/view\/5667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,11,27]]}},"URL":"https:\/\/doi.org\/10.25100\/cm.v54i3.5667","relation":{},"ISSN":["1657-9534"],"issn-type":[{"type":"electronic","value":"1657-9534"}],"subject":[],"published":{"date-parts":[[2023,11,30]]},"assertion":[{"value":"Yes","name":"crosschecked","label":"CrossChecked"},{"value":"Yes","name":"peer_reviewed","label":"Peer Reviewed"}]}}