{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:30:39Z","timestamp":1783467039953,"version":"3.55.0"},"reference-count":10,"publisher":"Universidad del Valle","issue":"4","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>Objetivo: Determinar la prevalencia, caracter\u00edsticas, momento de implantaci\u00f3n y pron\u00f3stico de los pacientes con bloqueo de rama izquierda del haz de His (BRIHH) e insuficiencia cardiaca aguda (ICA) tratados con terapia de resincronizaci\u00f3n cardiaca (TRC) en un registro real.\nM\u00e9todos: Se analizaron las caracter\u00edsticas de los pacientes con ICA y BRIHH en el momento de su inclusi\u00f3n en la cohorte EAHFE (Epidemiology Acute Heart Failure Emergency) para determinar la indicaci\u00f3n de TRC, el momento de implantaci\u00f3n y su impacto en la mortalidad por cualquier causa a 10 a\u00f1os.\nResultados: 729 pacientes con una mediana de edad de 82 a\u00f1os con una elevada carga de comorbilidades y dependencia funcional. La mediana de la fracci\u00f3n de eyecci\u00f3n del ventr\u00edculo izquierdo (FEVI) fue del 40%. 46 pacientes (6%) fueron tratados con TRC en alg\u00fan momento del seguimiento, con una mediana de tiempo de retraso para la implantaci\u00f3n de la TRC de 960 dias (IQR=1,147 d\u00edas) y al menos 108 pacientes no tratados cumpl\u00edan criterios para TRC. Los pacientes que recibieron TRC eran m\u00e1s j\u00f3venes, ten\u00edan comorbilidades diferentes, menor dependencia funcional (\u00edndice de Barthel m\u00e1s alto) y valores de FEVI m\u00e1s bajos. La mediana de seguimiento fue de 5.7 a\u00f1os (IC del 95%: 5.6-5.8) y la TRC no se asoci\u00f3 a cambios en la mortalidad a 10 a\u00f1os (HR ajustado: 1.33; IC del 95%: 0.72-2.48; p-valor 0.4). Cuando se compar\u00f3 con pacientes no tratados que cumpl\u00edan criterios para TRC, se observaron resultados muy similares (HR ajustado 1.34; IC del 95%: 0.67-2.68).\nConclusiones: La implantaci\u00f3n de la TRC se retras\u00f3 y se infrautiliz\u00f3 en pacientes con ICA y BRIHH. En estas circunstancias, la TRC no se asocia a una reducci\u00f3n de la mortalidad por cualquier causa a largo plazo.<\/jats:p>","DOI":"10.25100\/cm.v54i4.5850","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T18:29:58Z","timestamp":1721845798000},"page":"e2015850","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Terapia de resincronizaci\u00f3n cardiaca en insuficiencia cardiaca aguda y bloqueo de rama izquierda en un registro real","Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry"],"prefix":"10.25100","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-8508","authenticated-orcid":false,"given":"Oriol","family":"Aguilo Pedret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-3475","authenticated-orcid":false,"given":"Joan Carles","family":"Trull\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9531-6451","authenticated-orcid":false,"given":"Bego\u00f1a","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-0640","authenticated-orcid":false,"given":"Pedro","family":"L\u00f3pez-Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-0579","authenticated-orcid":false,"given":"V\u00edctor","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-5071","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"L\u00f3pez-Grima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-5008","authenticated-orcid":false,"given":"Pablo","family":"Herrera-Puente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1101-1066","authenticated-orcid":false,"given":"Javier","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-5804","authenticated-orcid":false,"given":"Mar\u00eda del Pilar","family":"L\u00f3pez-D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-4882","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3499-9089","authenticated-orcid":false,"given":"Javier","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-3611","authenticated-orcid":false,"given":"Alfonso","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-9357","authenticated-orcid":false,"given":"Pascual","family":"Pi\u00f1era","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-6405","authenticated-orcid":false,"given":"Christian E.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-7179","authenticated-orcid":false,"given":"Pere","family":"Llorens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-166X","authenticated-orcid":false,"given":"\u00d2scar","family":"Miro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10728","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"61564","doi-asserted-by":"crossref","unstructured":"- McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., B\u00f6hm, M., Burri, H., Butler, J., \u010celutkien\u0117, J., Chioncel, O., Cleland, J. G. F., Coats, A. J. S., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., Lainscak, M., \u2026 ESC Scientific Document Group (2021). 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European heart journal, 42(36), 3599\u20133726. https:\/\/doi.org\/10.1093\/eurheartj\/ehab368","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"61565","doi-asserted-by":"crossref","unstructured":"- Cleland, J. G. F., Bristow, M. R., Freemantle, N., Olshansky, B., Gras, D., Saxon, L., Tavazzi, L., Boehmer, J., Ghio, S., Feldman, A. M., Daubert, J. C., & de Mets, D. (2022). The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual patient data meta-analysis of COMPANION and CARE-HF. European journal of heart failure, 24(6), 1080\u20131090. https:\/\/doi.org\/10.1002\/ejhf.2524","DOI":"10.1002\/ejhf.2524"},{"key":"61566","doi-asserted-by":"crossref","unstructured":"- Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrab\u00e9s, J. A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A. J. S., Deharo, J. C., Delgado, V., Diller, G. P., Israel, C. W., Keren, A., Knops, R. E., Kotecha, D., Leclercq, C., \u2026 Witte, K. K. (2022). 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 24(1), 71\u2013164. https:\/\/doi.org\/10.1093\/europace\/euab232","DOI":"10.1093\/europace\/euac023"},{"key":"61567","doi-asserted-by":"crossref","unstructured":"- Raatikainen, M. J., Arnar, D. O., Zeppenfeld, K., Merino, J. L., Levya, F., Hindriks, G., & Kuck, K. H. (2015). Statistics on the use of cardiac electronic devices and electrophysiological procedures in the European Society of Cardiology countries: 2014 report from the European Heart Rhythm Association. Europace: European pacing, arrhythmias, and cardiac electrophysiology: journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 17 Suppl 1, i1\u2013i75. https:\/\/doi.org\/10.1093\/europace\/euu300","DOI":"10.1093\/europace\/euu300"},{"key":"61568","doi-asserted-by":"crossref","unstructured":"- Mullens, W., Auricchio, A., Martens, P., Witte, K., Cowie, M. R., Delgado, V., Dickstein, K., Linde, C., Vernooy, K., Leyva, F., Bauersachs, J., Israel, C. W., Lund, L. H., Donal, E., Boriani, G., Jaarsma, T., Berruezo, A., Traykov, V., Yousef, Z., Kalarus, Z., \u2026 Leclercq, C. (2020). Optimized implementation of cardiac resynchronization therapy: a call for action for referral and optimization of care: A joint position statement from the Heart Failure Association (HFA), European Heart Rhythm Association (EHRA), and European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology. European journal of heart failure, 22(12), 2349\u20132369. https:\/\/doi.org\/10.1002\/ejhf.2046","DOI":"10.1002\/ejhf.2046"},{"key":"61569","doi-asserted-by":"crossref","unstructured":"- Llorens, P., Javaloyes, P., Mart\u00edn-S\u00e1nchez, F. J., Jacob, J., Herrero-Puente, P., Gil, V., Garrido, J. M., Salvo, E., Fuentes, M., Alonso, H., Richard, F., Lucas, F. J., Bueno, H., Parissis, J., M\u00fcller, C. E., Mir\u00f3, \u00d2., & ICA-SEMES Research Group (2018). Time trends in characteristics, clinical course, and outcomes of 13,791 patients with acute heart failure. Clinical research in cardiology, 107(10), 897\u2013913. https:\/\/doi.org\/10.1007\/s00392-018-1261-z","DOI":"10.1007\/s00392-018-1261-z"},{"key":"61570","doi-asserted-by":"crossref","unstructured":"- L\u00e9vesque, L. E., Hanley, J. A., Kezouh, A., & Suissa, S. (2010). Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes. BMJ (Clinical research ed.), 340, b5087. https:\/\/doi.org\/10.1136\/bmj.b5087","DOI":"10.1136\/bmj.b5087"},{"key":"61571","doi-asserted-by":"crossref","unstructured":"- Bradburn, M. J., Clark, T. G., Love, S. B., & Altman, D. G. (2003). Survival analysis part II: multivariate data analysis--an introduction to concepts and methods. British journal of cancer, 89(3), 431\u2013436. https:\/\/doi.org\/10.1038\/sj.bjc.6601119","DOI":"10.1038\/sj.bjc.6601119"},{"key":"61572","doi-asserted-by":"crossref","unstructured":"- Osmanska, J., Hawkins, N. M., Toma, M., Ignaszewski, A., & Virani, S. A. (2018). Eligibility for cardiac resynchronization therapy in patients hospitalized with heart failure. ESC heart failure, 5(4), 668\u2013674. https:\/\/doi.org\/10.1002\/ehf2.12297","DOI":"10.1002\/ehf2.12297"},{"key":"61573","doi-asserted-by":"crossref","unstructured":"- Aguil\u00f3, O., Castells, X., Mir\u00f3, \u00d2., Mueller, C., Chioncel, O., & Trull\u00e0s, J. C. (2022). The prognostic significance of bundle branch block in acute heart failure: a systematic review and meta-analysis. Clinical research in cardiology: official journal of the German Cardiac Society, 10.1007\/s00392-022-02105-z. Advance online publication. https:\/\/doi.org\/10.1007\/s00392-022-02105-z","DOI":"10.1007\/s00392-022-02105-z"}],"container-title":["Colombia Medica"],"original-title":[],"link":[{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5850\/8076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5850\/8079","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5850\/8078","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/5850\/8077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:50:20Z","timestamp":1777945820000},"score":1,"resource":{"primary":{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/view\/5850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,5,22]]}},"URL":"https:\/\/doi.org\/10.25100\/cm.v54i4.5850","relation":{},"ISSN":["1657-9534","0120-8322"],"issn-type":[{"value":"1657-9534","type":"electronic"},{"value":"0120-8322","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"Yes","name":"crosschecked","label":"CrossChecked"},{"value":"Yes","name":"peer_reviewed","label":"Peer Reviewed"}]}}