{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:29:14Z","timestamp":1790094554506,"version":"4.0.1"},"reference-count":17,"publisher":"Universidad del Valle","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>Descripci\u00f3n de los caso: Se presenta una serie de 6 casos con diagn\u00f3stico probable ECJ espor\u00e1dica, atendidos en un hospital peruano de referencia nacional.\nHallazgos cl\u00ednicos: Los signos cl\u00ednicos relevantes fueron la demencia r\u00e1pidamente progresiva y las mioclonias , seguidas del mutismo acin\u00e9ticos y signos piramidales .\nTratamiento y resultados: De los casos presentados , el 80% fueron varones , con edad de presentaci\u00f3n promedio a los 65 a\u00f1os y tiempo de duraci\u00f3n desde el diagnostico hasta el deceso de 6.5 meses . Se realizo ex\u00e1menes de laboratorio, im\u00e1genes ( Resonancia Cerebral) y dosaje de prote\u00edna 14.3.3 para apoyo a la sospecha cl\u00ednica .No se cuenta con un tratamiento efectivo al momento para dicha patolog\u00eda\nRelevancia clinica: La enfermedad de Creutzfeldt-Jakob (ECJ) es una enfermedad neurodegenerativa, progresiva, mortal, de baja prevalencia e incidencia . Se requiere de gran sospecha cl\u00ednica y la exclusi\u00f3n de otras etiolog\u00edas. Actualmente no hay un tratamiento para esta entidad y hay alta probabilidad de muerte antes del a\u00f1o.\n\u00a0<\/jats:p>","DOI":"10.25100\/cm.v55i1.5821","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T14:56:52Z","timestamp":1729263412000},"page":"e2035821","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Enfermedad de Creutzfeldt Jakob espor\u00e1dica: Serie de casos en Per\u00fa"],"prefix":"10.25100","volume":"55","author":[{"given":"Stefany Lizet","family":"Espinoza Ram\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Canales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Barreto-Acevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10728","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"87417","doi-asserted-by":"crossref","unstructured":"Baldwin KJ, Correll CM. 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