{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T15:40:01Z","timestamp":1744040401633,"version":"3.40.3"},"reference-count":11,"publisher":"Universidad del Valle","issue":"3","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>Descripci\u00f3n del caso: Paciente masculino de 49 a\u00f1os, trabajador rural, con un cuadro de dos d\u00edas de evoluci\u00f3n de fiebre. El tratamiento inicial para neumon\u00eda adquirida en la comunidad fue seguido por el desarrollo de confusi\u00f3n y signos men\u00edngeos. Se confirm\u00f3 infecci\u00f3n por el virus de la encefalitis equina occidental, El paciente requiri\u00f3 cuidados intensivos prolongados debido a s\u00edndrome de hipoventilaci\u00f3n central, una complicaci\u00f3n no descrita previamente para esta enfermedad.\nHallazgos cl\u00ednicos:El paciente present\u00f3 encefalopat\u00eda por hipercapnia, con lesiones en la protuberancia visualizadas por resonancia magn\u00e9tica. Las pruebas de impulso respiratorio confirmaron hipoventilaci\u00f3n central. La fuerza muscular perif\u00e9rica estaba conservada, descart\u00e1ndose compromiso muscular o neurol\u00f3gico perif\u00e9rico. Se observ\u00f3 alcalosis metab\u00f3lica persistente secundaria a intentos fallidos de desvinculaci\u00f3n de la ventilaci\u00f3n mec\u00e1nica.\n Tratamiento y resultados:El tratamiento incluy\u00f3 ventilaci\u00f3n mec\u00e1nica, ventilaci\u00f3n invasiva nocturna y acetazolamida para abordar la alcalosis metab\u00f3lica post-hipercapnia. La mejor\u00eda gradual permiti\u00f3 una decanulaci\u00f3n exitosa a los 46 d\u00edas. A los 30 d\u00edas del alta, el paciente report\u00f3 independencia total y reincorporaci\u00f3n laboral, con funci\u00f3n respiratoria y equilibrio \u00e1cido-base estables.\n Relevancia cl\u00ednica:Este caso destaca el s\u00edndrome de hipoventilaci\u00f3n central como una complicaci\u00f3n rara pero significativa de la encefalitis equina occidental. El uso de acetazolamida fue efectivo para manejar la alcalosis metab\u00f3lica, respaldando su potencial utilidad en casos similares. Se requiere m\u00e1s investigaci\u00f3n para explorar esta complicaci\u00f3n y establecer estrategias de manejo basadas en evidencia.<\/jats:p>","DOI":"10.25100\/cm.v55i3.6404","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T19:35:14Z","timestamp":1743795314000},"page":"e5006404","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["S\u00edndrome de hipoventilaci\u00f3n central, una complicaci\u00f3n at\u00edpica de la encefalitis equina."],"prefix":"10.25100","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-4176","authenticated-orcid":false,"given":"Laura","family":"Rapela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1577-1582","authenticated-orcid":false,"given":"Luc\u00eda","family":"Derosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5791-8085","authenticated-orcid":false,"given":"Alberto","family":"Quereda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6345-1462","authenticated-orcid":false,"given":"Gast\u00f3n","family":"Capodarco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-3683","authenticated-orcid":false,"given":"Mauro","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10728","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"90716","unstructured":"Ministerio de Salud Argentina. Vigilancia de Encefalitis Equina del Oeste. Boletin Epidemiologico 50. Ministerio de Salud de la provincia de Buenos Aires; 2023. https:\/\/www.ms.gba.gov.ar\/sitios\/media\/ f iles\/2023\/12\/Bolet%C3%ADn-epidemiol%C3%B3gico_50.pdf"},{"key":"90717","doi-asserted-by":"crossref","unstructured":"Avil\u00e9s G, Sabattini MS, Mitchell CJ. Transmission of western equine encephalomyelitis virus by Argentine Aedes albifasciatus (Diptera: Culicidae). J Med Entomol. 1992;29(5):850-853. https:\/\/doi.org\/10.1093\/jmedent\/29.5.850 PMid:1404265","DOI":"10.1093\/jmedent\/29.5.850"},{"key":"90718","unstructured":"Fernandez, G; Amelotti, L; Nicolau, V; Guereca Reyes, C; Vallone, A; Buyayisqui, MP, et al. Bolet\u00edn epidemiol\u00f3gico nacional. Argentina: Ministerio de salud de la Rep\u00fablica Argentina, 2024: 693."},{"key":"90719","doi-asserted-by":"crossref","unstructured":"Trang, H; Samuels, M; Ceccherini, I; Frerick, M; Garc\u00eda-Teresa, MA; Peters, J: et alGuidelines for diagnosis and managment of congenital central hypoventilation syndrome. Orphanet J Rare Dis. 2020; 15(1): 252. https:\/\/doi.org\/10.1186\/s13023-020-01460-2 PMid:32958024 PMCid:PMC7503443","DOI":"10.1186\/s13023-020-01460-2"},{"key":"90720","doi-asserted-by":"crossref","unstructured":"Xu Q, Wang Q, Han J, Mao F, Zeng S, Chen S, et al. Central hypoventilation is a key risk factor for mechanical ventilation during the acute phase of Anti-N-Methyl-D-Aspartate Receptor encephalitis. Frontiers in Neurology. 2021; 12:728594 https:\/\/doi.org\/10.3389\/fneur.2021.728594 PMid:34795627 PMCid:PMC8594565","DOI":"10.3389\/fneur.2021.728594"},{"key":"90721","doi-asserted-by":"crossref","unstructured":"Voronova M, Shark A. Severe central hypoventilation syndrome in a patient with Anti-N-Methyl-D-Aspartate receptor encephalitis: case report and review of the literature. Cureus. 2022; 14(10):e30749. https:\/\/doi.org\/10.7759\/cureus.30749 PMid:36447716 PMCid:PMC9700408","DOI":"10.7759\/cureus.30749"},{"key":"90722","doi-asserted-by":"crossref","unstructured":"Tso G, Kaldas K, Springer J, Barot N, Kamangar N. West Nile Meningoencephalitis presenting as isolated bulbar palsy with hypercapnic respiratory failure: case report and literature review. J Intensive Care Med. 2016; 31(4):285-287 https:\/\/doi.org\/10.1177\/0885066615589734 PMid:26065427","DOI":"10.1177\/0885066615589734"},{"key":"90723","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Choco MJ, Zarranz JJ, Saiz A, Forcadas MI, Graus F. Central hypoventilation as the presenting symptom in Hu associated paraneoplastic encephalomyelitis. J Neurol Neurosurg Psychiatry. 2007; 78(10):1143-5 https:\/\/doi.org\/10.1136\/jnnp.2007.117994 PMid:17878194 PMCid:PMC2117560","DOI":"10.1136\/jnnp.2007.117994"},{"key":"90724","doi-asserted-by":"crossref","unstructured":"AlOtair HA, Alzeer AH, Abdou MA, Qasrawi SO. Unusual case of central alveolar hypoventilation. Saudi Med J. 2018;39(3):305-310. https:\/\/doi.org\/10.15537\/smj.2018.3.210803 PMid:29543311 PMCid:PMC5893922","DOI":"10.15537\/smj.2018.3.210803"},{"key":"90725","doi-asserted-by":"crossref","unstructured":"Jones P, Greenstone M. Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease. Cochrane Database Systematic Reviews. 2001; 1: CD002881. https:\/\/doi.org\/10.1002\/14651858.CD002881 PMid:11279770 PMCid:PMC6483619","DOI":"10.1002\/14651858.CD002881"},{"key":"90726","unstructured":"Fontana V, Santinelli S, Internullo M, Marinelli P, Sardo L, Alessandrini G, et al. Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients. Eur Rev Med Pharmacol Sci. 2016;20(1):37-43"}],"container-title":["Colombia Medica"],"original-title":[],"link":[{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/6404\/8237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/6404\/8238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/6404\/8235","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/6404\/8236","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/download\/6404\/8238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T15:20:12Z","timestamp":1744039212000},"score":1,"resource":{"primary":{"URL":"https:\/\/colombiamedica.univalle.edu.co\/index.php\/comedica\/article\/view\/6404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2,11]]}},"URL":"https:\/\/doi.org\/10.25100\/cm.v55i3.6404","relation":{},"ISSN":["1657-9534","0120-8322"],"issn-type":[{"type":"electronic","value":"1657-9534"},{"type":"print","value":"0120-8322"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"Yes","name":"crosschecked","label":"CrossChecked"},{"value":"Yes","name":"peer_reviewed","label":"Peer Reviewed"},{"value":"2024-09-30","name":"published","label":"Published"}]}}