{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:31:58Z","timestamp":1783063918412,"version":"3.54.6"},"reference-count":22,"publisher":"Universidad del Valle","issue":"4","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>AntecedentesLas lesiones sinonasales son masas benignas frecuentes con caracter\u00edsticas cl\u00ednicas e histopatol\u00f3gicas comunes. Las prote\u00ednas de la matriz extracelular, como la periostina, la fibronectina y la tenascina-C, desempe\u00f1an funciones clave en la remodelaci\u00f3n tisular y la inflamaci\u00f3n, pero sus perfiles de expresi\u00f3n en estas lesiones siguen estando poco definidos.\nObjetivoEste estudio compar\u00f3 los patrones inmunohistoqu\u00edmicos de periostina, fibronectina y tenascina-C en lesiones sinonasales para dilucidar su papel en la patog\u00e9nesis y mejorar el diagn\u00f3stico diferencial.\nM\u00e9todosEn este estudio retrospectivo se analizaron muestras patol\u00f3gicas de 70 pacientes operados de p\u00f3lipos sinonasales. Mediante un sistema de puntuaci\u00f3n semicuantitativo, se evalu\u00f3 por separado la expresi\u00f3n inmunohistoqu\u00edmica de periostina, fibronectina y tenascina-C en los compartimentos epitelial y estromal. El an\u00e1lisis de regresi\u00f3n log\u00edstica multinomial evalu\u00f3 las asociaciones entre los patrones de marcaci\u00f3n del tejido y los tipos de lesi\u00f3n.\nResultadosLa cohorte del estudio ten\u00eda una proporci\u00f3n hombre-mujer de 5:2 con una edad media de aproximadamente 40 a\u00f1os. Los p\u00f3lipos nasales mostraron una tinci\u00f3n de periostina estromal significativamente mayor que los p\u00f3lipos antrocoanales y los papilomas invertidos. Por el contrario, los p\u00f3lipos antrocoanales mostraron una expresi\u00f3n de periostina epitelial m\u00e1s elevada que los papilomas invertidos. La expresi\u00f3n de fibronectina aument\u00f3 notablemente en los p\u00f3lipos nasales, sobre todo en el estroma, lo que refuerza su papel en la remodelaci\u00f3n del tejido inflamatorio. En cambio, la tenascina-C no mostr\u00f3 diferencias significativas entre los tipos de lesi\u00f3n.\nConclusi\u00f3nLa expresi\u00f3n diferencial de periostina y fibronectina en las lesiones sinonasales se\u00f1ala la existencia de distintos mecanismos patog\u00e9nicos que pueden contribuir a un diagn\u00f3stico m\u00e1s preciso. Los patrones de expresi\u00f3n de periostina espec\u00edficos de cada compartimento y la expresi\u00f3n prominente de fibronectina en los p\u00f3lipos nasales sugieren que estos biomarcadores podr\u00edan servir como valiosas herramientas de diagn\u00f3stico y posibles dianas terap\u00e9uticas. Los estudios futuros deber\u00e1n explorar m\u00e1s a fondo estas v\u00edas para desarrollar intervenciones dirigidas a las enfermedades sinonasales.<\/jats:p>","DOI":"10.25100\/cm.v55i4.6411","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T12:41:23Z","timestamp":1746621683000},"page":"e2026411","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Per\u0131ost\u0131n and f\u0131bronect\u0131n \u0131n nasal les\u0131ons: key players \u0131n polyps and \u0131nverted pap\u0131llomas","Periostina y fibronectina en lesiones nasales: elementos clave en p\u00f3lipos y papilomas invertidos"],"prefix":"10.25100","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-7454","authenticated-orcid":false,"given":"Mehmet","family":"Birinci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-4718","authenticated-orcid":false,"given":"O\u011fuzhan","family":"Ok\u00e7u","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-0251","authenticated-orcid":false,"given":"Tu\u011fba","family":"Yemi\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5959-8937","authenticated-orcid":false,"given":"O\u011fuz","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-3649","authenticated-orcid":false,"given":"Suat","family":"Terzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9833-402X","authenticated-orcid":false,"given":"Metin","family":"\u00c7eliker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9245-1551","authenticated-orcid":false,"given":"\u00d6zlem \u00c7elebi","family":"Erdivanl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-1755","authenticated-orcid":false,"given":"Tolga","family":"Mercantepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2814-5194","authenticated-orcid":false,"given":"Levent","family":"T\u00fcmkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3955-8242","authenticated-orcid":false,"given":"Ba\u015far","family":"Erdivanl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2070-8677","authenticated-orcid":false,"given":"Engin","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10728","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"92988","doi-asserted-by":"crossref","unstructured":"Bakari A, Afolabi OA, Adoga AA, Kodiya AM, Ahmad BM. 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