{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:37:23Z","timestamp":1792820243779,"version":"4.5.0"},"reference-count":24,"publisher":"Universidad del Valle","issue":"2","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>Objectives: This study aimed to investigate whether serum Interleukin 36 gamma (IL-36\u03b3) levels in pediatric allergic rhinitis patients correlate with disease severity (mild, moderate, severe) and duration (intermittent, persistent). Additionally, we assessed the potential of IL-36\u03b3 as a biomarker and its role in disease pathogenesis to inform future treatment strategies.\nMethods: In this cross-sectional observational study, pediatric allergic rhinitis patients from outpatient clinics were compared with healthy controls. Serum IL-36\u03b3 levels were measured from blood samples and analyzed across subgroups based on disease severity and duration.\nResults: Fifty patients with allergic rhinitis and forty controls were included. IL-36\u03b3 levels were higher in the patient group with borderline significance (p= 0.050). Female patients had significantly higher IL-36\u03b3 levels than male controls (p= 0.044).\nConclusions:This is the first study to evaluate IL-36\u03b3 levels in pediatric allergic rhinitis. Although the difference between groups showed borderline significance, larger studies may confirm these findings. The observed gender-related difference suggests IL-36\u03b3 could be a potential biomarker. Additionally, a significant negative correlation with total IgE and a nonsignificant negative correlation with eosinophil counts were noted.<\/jats:p>","DOI":"10.25100\/cm.v56i2.6690","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T16:41:12Z","timestamp":1760719272000},"page":"e2016690","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Interleukin-36\u03b3 Levels in Children with Allergic Rhinitis","Niveles s\u00e9ricos de interleucina-36\u03b3 en ni\u00f1os con rinitis al\u00e9rgica"],"prefix":"10.25100","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-3841","authenticated-orcid":false,"given":"Dogukan","family":"Aydenizoz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-7599","authenticated-orcid":false,"given":"Omer Tarik","family":"Selcuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5317-431X","authenticated-orcid":false,"given":"Hulya","family":"Eyigor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-2547","authenticated-orcid":false,"given":"Hamit Yasar","family":"Ellidag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-9067","authenticated-orcid":false,"given":"Serkan","family":"Filiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8282-190X","authenticated-orcid":false,"given":"Sennur","family":"Keles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10728","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"98217","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.047"},{"key":"98218","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"98219","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000129"},{"key":"98220","unstructured":"Baroody FM, Naclerio RM. Allergy and Immunology of the Upper Airway. In. Valerie J. Lund, Editor 6th edition Cummings Otolaryngology. Philadelphia: Mosby\/Elsevier; 2015.p. 593-625."},{"key":"98221","unstructured":"Cox DR, Wise SK, Baroody FM Allergy and Immunology of the Upper Airway. Flint PW, Francis HW et al. Editor 7th edition Cummings Otolaryngology. Philadelphia: Mosby\/Elsevier; 2021.p. 558-585."},{"key":"98222","unstructured":"Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008. Allergy. 2008;63 Suppl 86:8-160."},{"key":"98223","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-00937-1"},{"key":"98224","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.02.008"},{"key":"98225","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.154992"},{"key":"98226","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.972"},{"key":"98227","unstructured":"Cingi C, Ure B. Nonalerjik rinit ve Alerjik Rinit. In: Cingi C, \u00e7eviri edit\u00f6r\u00fc. Current Otorinolaringoloji-Ba\u015f ve Boyun Cerrahisi Tan\u0131 ve Tedavi. Lalwani AK, edit\u00f6r. 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