{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T05:05:21Z","timestamp":1779858321531,"version":"3.53.1"},"reference-count":11,"publisher":"Universidad del Valle","issue":"4","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":true},"short-container-title":["Colomb Med"],"abstract":"<jats:p>Descripci\u00f3n del casoMujer de 28 a\u00f1os en per\u00edodo posparto que consult\u00f3 por cefalea intensa, fiebre y disminuci\u00f3n del nivel de conciencia. La PCR en el l\u00edquido cefalorraqu\u00eddeo detect\u00f3 185,000 copias de ADN del virus de Epstein-Barr.Hallazgos cl\u00ednicosLa neuroimagen evidenci\u00f3 edema cerebral difuso compatible con hipertensi\u00f3n intracraneal y ausencia de lesiones hemorr\u00e1gicas, lo que confirma encefalitis por virus de Epstein-Barr complicada con elevaci\u00f3n objetivamente documentada de la presi\u00f3n intracraneal.Tratamiento y desenlacesLa paciente recibi\u00f3 aciclovir intravenoso, fenito\u00edna y soluci\u00f3n salina hipert\u00f3nica y logr\u00f3 una recuperaci\u00f3n neurol\u00f3gica completa tras 21 d\u00edas de tratamiento.Relevancia cl\u00ednicaA nuestro conocimiento, este es el primer caso documentado de encefalitis no hemorr\u00e1gica por el virus de Epstein-Barr con hipertensi\u00f3n intracraneal objetivamente confirmada en el per\u00edodo posparto. El mecanismo m\u00e1s probable es el edema cerebral difuso inducido por inflamaci\u00f3n, que conduce a una alteraci\u00f3n de la autorregulaci\u00f3n cerebrovascular y a una elevaci\u00f3n subsecuente de la presi\u00f3n intracraneal. Los cl\u00ednicos deben incluir la infecci\u00f3n por el virus de Epstein-Barr en el diagn\u00f3stico diferencial de pacientes pu\u00e9rperas con encefalitis y signos de hipertensi\u00f3n intracraneal, incluso cuando la neuroimagen no muestre hallazgos hemorr\u00e1gicos.<\/jats:p>","DOI":"10.25100\/cm.v56i4.7067","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:34:37Z","timestamp":1778042077000},"page":"e5007067","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Intracranial hypertension due to Epstein-Barr virus encephalitis during the postpartum period","Hipertensi\u00f3n intracraneal debido a encefalitis por virus de Epstein-Barr durante el per\u00edodo posparto"],"prefix":"10.25100","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5375-3474","authenticated-orcid":false,"given":"Mar\u00eda Fernanda","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-7692","authenticated-orcid":false,"given":"Luis","family":"Fuenmayor Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9950-2740","authenticated-orcid":false,"given":"Nelson","family":"Remache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5967-3563","authenticated-orcid":false,"given":"Jorge","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2299-5850","authenticated-orcid":false,"given":"Daniel","family":"Pe\u00f1aherrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10728","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"106161","unstructured":"1. Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas y Bennett. Enfermedades infecciosas. Principios y pr\u00e1ctica. 9th edition. 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