{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:49:59Z","timestamp":1791438599935,"version":"4.3.3"},"reference-count":25,"publisher":"Universidad del Valle","issue":"1","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["colombiamedica.univalle.edu.co"],"crossmark-restriction":false},"short-container-title":["Colomb Med"],"abstract":"<jats:p>ObjectiveThis study aimed to determine frailty prevalence among patients aged \u226565 diagnosed with Chronic Obstructive Pulmonary Disease (COPD) and investigate its relationship with disease severity, hospitalization rates, and acute exacerbation frequency.MethodsThis cross-sectional study evaluated 112 elderly patients with COPD. Patient records, pulmonary function tests, Modified Medical Research Council (mMRC) dyspnea scores, COPD Assessment Test (CAT) scores, and the previous year's exacerbations and hospitalizations were analyzed. Frailty was assessed using the FRAIL scale.ResultsFrailty prevalence was 49.1% (55\/112). A significant negative correlation was found between FRAIL and FEV1% values (rs: -0.695, 95% CI: -0.782 to -0.581,\u00a0p\u00a0&lt;0.001). Conversely, FRAIL scores correlated positively with CAT (rs: 0.840, 95% CI: 0.773 to 0.888,\u00a0p\u00a0&lt;0.001) and mMRC values (rs: 0.733, 95% CI: 0.631 to 0.811,\u00a0p\u00a0&lt;0.001). Significant differences in CAT, mMRC, and FEV1% were observed between high and low frailty groups. COPD exacerbations and hospitalizations were significantly higher in patients with higher FRAIL scores (p\u00a0&lt;0.001).ConclusionThe FRAIL scale is strongly associated with higher rates of exacerbations and hospitalizations in elderly COPD patients, reflecting increased disease severity and poorer clinical outcomes.<\/jats:p>","DOI":"10.25100\/cm.v57i1.6595","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:53:36Z","timestamp":1790225616000},"page":"e2006595","update-policy":"https:\/\/doi.org\/10.25100\/cm.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Frailty in elderly COPD patients","Fragilidad en pacientes adultos mayores con EPOC"],"prefix":"10.25100","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-4049","authenticated-orcid":false,"given":"Mustafa Ilteris","family":"Bardakci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2439-3964","authenticated-orcid":false,"given":"Fatih","family":"Ozcelik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5213-7234","authenticated-orcid":false,"given":"Mihriban","family":"Simsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-3844","authenticated-orcid":false,"given":"Gulhan Ayhan","family":"Albayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10728","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"107895","doi-asserted-by":"crossref","unstructured":"1. 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Determinants of frailty in primary care patients with COPD: the Greek UNLOCK study. BMC Pulm Med. 2019;19(1):63. https:\/\/doi.org\/10.1186\/s12890-019-0824-8. PMid:30876423; PMCid:PMC6419845","DOI":"10.1186\/s12890-019-0824-8"},{"key":"107914","doi-asserted-by":"crossref","unstructured":"20. Park SK, Richardson CR, Holleman RG, Larson JL. Frailty in people with COPD, using the National Health and Nutrition Evaluation Survey dataset (2003\u20132006). Heart Lung. 2013;42(3):163-70. https:\/\/doi.org\/10.1016\/j.hrtlng.2012.07.004. PMid:23535142; PMCid:PMC4020241","DOI":"10.1016\/j.hrtlng.2012.07.004"},{"key":"107915","doi-asserted-by":"crossref","unstructured":"21. Naval E, Gonz\u00e1lez MC, Girald\u00f3s S, Calatayud J, Jornet M, Lluch I, et al. Frailty assessment in a stable COPD cohort: \u0131s there a COPD-Frail Phenotype? COPD. 2021;18(5):525-32. https:\/\/doi.org\/10.1080\/15412555.2021.1975670. 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