{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:31:09Z","timestamp":1761921069629},"reference-count":23,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>Adherence to medical treatment in chronic patients challenging, especially in primary prevention where the benefit is not directly perceived by the patient. Through the directed interview of this qualitative study we assessed some specific factors that intervene in beta-blockers adherence in cirrhotic patients with oesophageal varices in primary prevention in Romanian. We identified that the most important modifiable extrinsic factor that influences adherence is the confidence in medicine. The intensely negative perception of the disease seemed to be another major driver of adherence.<\/jats:p>","DOI":"10.25122\/jml-2018-1006","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T12:50:41Z","timestamp":1668689441000},"page":"355-358","source":"Crossref","is-referenced-by-count":2,"title":["Specific Factors That Influence Adherence to Beta Blocker Treatment in Primary Prevention of Variceal Bleeding in Cirrhotic Romanian Patients. a Proof of Concept Qualitative Study"],"prefix":"10.25122","volume":"11","author":[{"given":"Silvia","family":"Sovaila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Gastroenterology Department, University of Medicine and Pharmacy, Craiova, Romania","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Internal Medicine Clinic \u201cInternist.ro\u201d, Brasov, Romania","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Silvia Sovaila, Internist.ro, Bra\u0219ov, 63 N B\u0103lcescu, 500019, Bra\u0219ov, Rom\u00e2nia, Tel.: 0040 733 911 513; E-mail: sovaila.silvia@internist.ro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Purcarea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Internal Medicine Clinic \u201cInternist.ro\u201d, Brasov, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Gheonea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Gastroenterology Department, University of Medicine and Pharmacy, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudorel","family":"Ciurea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Gastroenterology Department, University of Medicine and Pharmacy, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2018,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"C. Tarquinio, M.-P.Tarquinio. Therapeutic observance: determinants and models. Pratiques Psychologiques 2007,13:1\u201319.","DOI":"10.1016\/j.prps.2006.09.005"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"DiMatteo MR. Variations in patients\u2019 adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 2004,42:200\u2013209.","DOI":"10.1097\/01.mlr.0000114908.90348.f9"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"van Dulmen S, Sluijs E, van Dijk L, de Ridder D, Heerdink R, Bensing J. Patient adherence to medical treatment: a review of reviews. BMC Health Serv Res 2007,7:55.","DOI":"10.1186\/1472-6963-7-55"},{"key":"ref4","unstructured":"OMS. http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/42682\/9241545992.pdf?sequence=1. 2003."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Haynes RB, McKibbon KA, Kanani R. Systematic review of randomised trials of interventions to assist patients to follow prescriptions for medications. Lancet 1996, 348:383-386.","DOI":"10.1016\/S0140-6736(96)01073-2"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008:CD000011.","DOI":"10.1002\/14651858.CD000011.pub3"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Polis S, Zang L, Mainali B, Pons R, Pavendranathan G, Zekry A, et al. Factors associated with medication adherence in patients living with cirrhosis. J Clin Nurs 2016, 25:204-212.","DOI":"10.1111\/jocn.13083"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Hayward KL, Valery PC, Cottrell WN, Irvine KM, Horsfall LU, Tallis CJ, et al. Prevalence of medication discrepancies in patients with cirrhosis: a pilot study. BMC Gastroenterol 2016,16:114.","DOI":"10.1186\/s12876-016-0530-4"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Chen SL, Tsai JC, Lee WL. The impact of illness perception on adherence to therapeutic regimens of patients with hypertension in Taiwan. J Clin Nurs 2009,18:2234\u20132244.","DOI":"10.1111\/j.1365-2702.2008.02706.x"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Roebuck MC, Kaestner RJ, Dougherty JS. Impact of Medication Adherence on Health Services Utilization in Medicaid. Med Care 2018,56:266\u2013273.","DOI":"10.1097\/MLR.0000000000000870"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002,40:794\u2013811.","DOI":"10.1097\/00005650-200209000-00009"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Hayward KL, Horsfall LU, Ruffin BJ, Cottrell WN, Chachay VS, Irvine KM, et al. Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management. Intern Med J 2017,47:952\u2013955.","DOI":"10.1111\/imj.13505"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Arthurs G, Simpson J, Brown A, Kyaw O, Shyrier S, Concert CM. The effectiveness of therapeutic patient education on adherence to oral anti-cancer medicines in adult cancer patients in ambulatory care settings: a systematic review. JBI Database System Rev Implement Rep 2015,13:244\u2013292.","DOI":"10.11124\/jbisrir-2015-2057"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Vodermaier A, Caspari C, Koehm J, Kahlert S, Ditsch N, Untch M. Contextual factors in shared decision making: a randomised controlled trial in women with a strong suspicion of breast cancer. Br J Cancer 2009,100:590\u2013597.","DOI":"10.1038\/sj.bjc.6604916"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Gebreweld FH, Kifle MM, Gebremicheal FE, Simel LL, Gezae MM, Ghebreyesus SS, et al. Factors influencing adherence to tuberculosis treatment in Asmara, Eritrea: a qualitative study. J Health Popul Nutr 2018,37:1.","DOI":"10.1186\/s41043-017-0132-y"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Sulaiman I, Greene G, MacHale E, Seheult J, Mokoka M, D\u2019Arcy S, et al. A randomised clinical trial of feedback on inhaler adherence and technique in patients with severe uncontrolled asthma. Eur Respir J 2018,51.","DOI":"10.1183\/13993003.01126-2017"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Kucukarslan SN. A review of published studies of patients\u2019 illness perceptions and medication adherence: lessons learned and future directions. Res Social Adm Pharm 2012,8:371\u2013382.","DOI":"10.1016\/j.sapharm.2011.09.002"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Hsiao CY, Chang C, Chen CD. An investigation on illness perception and adherence among hypertensive patients. Kaohsiung J Med Sci 2012,28:442\u2013447.","DOI":"10.1016\/j.kjms.2012.02.015"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Ross S, Walker A, MacLeod MJ. Patient compliance in hypertension: role of illness perceptions and treatment beliefs. J Hum Hypertens 2004,18:607\u2013613.","DOI":"10.1038\/sj.jhh.1001721"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Hayward KL, Valery PC, Martin JH, Karmakar A, Patel PJ, Horsfall LU, et al. Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis. World J Gastroenterol 2017, 23:7321\u20137331.","DOI":"10.3748\/wjg.v23.i40.7321"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Spiru L, Trascu RI, Turcu I, Marzan M. Perpetual transitions in Romanian healthcare. EPMA J 2011,2:341-350.","DOI":"10.1007\/s13167-011-0135-5"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Kuba S, Maeda S, Matsumoto M, Yamanouchi K, Yano H, Morita M, et al. Adherence to Adjuvant Endocrine Therapy in Women With Breast Cancer: A Prospective Observational Study in Japanese Women. Clin Breast Cancer 2018,18:150\u2013156.","DOI":"10.1016\/j.clbc.2017.12.003"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"West LM, Borg Theuma R, Cordina M. Health locus of control: Its relationship with medication adherence and medication wastage. Res Social Adm Pharm 2017.","DOI":"10.1016\/j.sapharm.2017.12.003"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-11-355.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T12:50:52Z","timestamp":1668689452000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-11-355.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["JMedLife-11-355"],"URL":"https:\/\/doi.org\/10.25122\/jml-2018-1006","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"type":"print","value":"1844-122X"},{"type":"electronic","value":"1844-3117"}],"subject":[],"published":{"date-parts":[[2018,10]]}}}