{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:04:37Z","timestamp":1769925877547,"version":"3.49.0"},"reference-count":23,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>There is evidence that infection by <jats:italic>H. pylori<\/jats:italic> can have a critical proportion in the development of hepatocyte injury and both noncancerous and malignant liver conditions including non-alcoholic fatty liver disease (NAFLD). This is attributed to several mechanisms, the most important one being the toxic products of the bacterium <jats:italic>H. pylori<\/jats:italic> and oxidative injury for hepatocytes which promotes hepatic injury. The present research was aimed at determining the association between <jats:italic>H. pylori<\/jats:italic> infection and the prevalence of NAFLD in Birjand, Iran. Two groups were included in this cross-sectional study at the outpatient university clinic. One group had NAFLD (65 patients) and the other group was healthy controls without NAFLD (65 subjects). The diagnosis of NAFLD was performed using abdominal ultrasound examination and the absence of taking steatogenic medications or alcohol. Serum anti-<jats:italic>H. pylori<\/jats:italic> IgG and fecal <jats:italic>H. pylori<\/jats:italic> antigen were tested for diagnosing of <jats:italic>H. pylori<\/jats:italic> infection using ELISA method. <jats:italic>H. pylori<\/jats:italic> infection diagnosis was made if both tests were positive. None of the subjects in either group had symptoms related to the digestive system including dyspepsia, GERD (gastroesophageal reflux disease), or epigastric pain suspicious of peptic ulcer disease. There were 37 patients (28.5%) in both NAFLD (22 cases, 33.8%) and control (15 cases, 23.1%) groups whose <jats:italic>H. pylori<\/jats:italic> tests (both IgG and fecal antigen) were positive. Statistically, no significant difference was observed between the two studied groups regarding <jats:italic>H. pylori<\/jats:italic> infection frequency (p = 0.37). Asymptomatic <jats:italic>H. pylori<\/jats:italic> infection rate was not significantly different between NAFLD patients and control subjects in Birjand, Iran.<\/jats:p>","DOI":"10.25122\/jml-2019-0012","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T12:37:20Z","timestamp":1668688640000},"page":"168-172","source":"Crossref","is-referenced-by-count":17,"title":["Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran"],"prefix":"10.25122","volume":"12","author":[{"given":"Mahyar","family":"Mohammadifard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Radiology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeinab","family":"Saremi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine, School of Medicine, Birjand University of Medical Science, Birjand, Iran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Zeinab Saremi, Department of Internal Medicine, School of Medicine, Birjand University of Medical Science, Birjand, Iran, Tel: 00989155340380, E-mail: zsaremi@bums.ac.ir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboobe","family":"Rastgoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"General Practitioner, Imam Reza Hospital, Birjand, Iran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsan","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine, School of Medicine, Birjand University of Medical Science, Birjand, Iran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"1. 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