{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T07:56:10Z","timestamp":1723017370875},"reference-count":40,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"3","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>The final stage of the diagnostic of primary hyperaldosteronism is to identify the causes of excessive secretion of aldosterone and determination of its variants. Based on the analysis of literature data, the diagnostic value, sensitivity and specificity of the methods of radiation diagnostics for primary hyperaldosteronism were assessed: ultrasound, computed tomography, magnetic resonance imaging, photon emission tomography, magnetic resonance spectroscopy, scintigraphy with iodine radiopharmaceuticals. The causes of false-positive and false-negative evaluations of changes in adrenal glands in the application of these diagnostics have been analyzed. There are many genetic and morphological studies when searching the literature data on the principles and methods of distinguishing the nosological forms of primary hyperaldosteronism based on the results of the aldosterone level estimation in the separated blood from the central veins of both adrenal glands or segmental veins of one gland with subsequent determination of the concentration gradient. It was noted that topical diagnostics and, especially, the determination of nosological forms of primary hyperaldosteronism are complex and expensive, but their results allow choosing an appropriate treatment approach for each particular case.<\/jats:p>","DOI":"10.25122\/jml-2019-0073","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T05:39:22Z","timestamp":1573796362000},"page":"215-220","source":"Crossref","is-referenced-by-count":4,"title":["Laboratory Diagnostics of Primary Hyperaldosteronism and its Peculiarities (Literature Review)"],"prefix":"10.25122","volume":"12","author":[{"given":"O","family":"Shidlovskyi Viktor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Shidlovskyi Oleander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Sheremet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Michael I. Sheremet, 1st Surgery Department of Bukovinian State Medical University, Holovna str., 191, 58018 Chernovtsy, Ukraine, Tel.: +380956064607, E-mail: mihayl71@gmail.com","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Zhulkevych Igor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Andreychyn Sergyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Hanberher Inna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Smachylo Ivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Dobrorodny Volodimir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Futuima Yuryi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1st Surgery Department of I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2019,7]]},"reference":[{"unstructured":"Shomchenko SV, Ukrainian EP Innovations and achievements in the diagnosis and treatment of urolithiasis (literature review). Ukrainian scientific and practical journal of urologists, andrologists and nephrologists. 2012; 31(12):44\u201357.","key":"ref1"},{"unstructured":"Stepanova Yu.A., Timina IE, Ashivkina OI, Vetsheva NN, Kosova IA, Berelavichus SV. Adrenal tumors: clinical diagnosis (review of the literature). Medical imaging. 2014;2:48\u201360.","key":"ref2"},{"doi-asserted-by":"crossref","unstructured":"Molashenko NV, Yukina M.Yu., Soldatova EA et al. Volumetric formations of adrenal glands (diagnostics and differential diagnostics). Problems of endocrinology. 2010;1:48\u201352.","key":"ref3","DOI":"10.14341\/probl201056148-56"},{"doi-asserted-by":"crossref","unstructured":"Nurnberg D. Ultrasound of adrenal gland tumours and indications for fine needle biopsy (uFNB). Ultraschall. Med. 2005; 26 (6): 458\u2013469. 47. DOI: 10.1055\/s-2005-858885","key":"ref4","DOI":"10.1055\/s-2005-858885"},{"doi-asserted-by":"crossref","unstructured":"Low G.1., Dhliwayo H., Lomas D.J. Adrenal neoplasms. Clin. Radiol. 2012; 67 (10): 988\u20131000. DOI: 10.1016\/j.crad.2012.02.005","key":"ref5","DOI":"10.1016\/j.crad.2012.02.005"},{"unstructured":"Practical guide to ultrasound diagnostics. General ultrasound diagnostics. Mitkov VV Editors. Moscow: Vidar M. 2005:495\u2013499. doi: 10.24026\/18181384.4(52).2015.76156.","key":"ref6"},{"unstructured":"V.Yu. Selchuk, A.A. Baronin, A.V. Filimonyuk. Primary and metastatic tumors of adrenal glands. Russian medical journal. 2005;1:862\u2013869.","key":"ref7"},{"doi-asserted-by":"crossref","unstructured":"Pamela T. Johnson, Karen M. Horton, Elliot K. Fishman Adrenal Imaging with Multidetector CT: Evidence-based Protocol Optimization and Interpretative Practice\/\/HomeRadioGraphics Vol. 29, No. 5 Published Online:Sep 1 2009 https:\/\/doi.org\/10.1148\/rg.2950950267.","key":"ref8","DOI":"10.1148\/rg.295095026"},{"unstructured":"Andrew Murphy and Dr Jeremy Jones et al. Adrenal adenoma\/\/ https:\/\/radiopaedia.org\/articles\/adrenal-adenoma?lang=us)","key":"ref9"},{"unstructured":"Gabriel I Uwaifo, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP Primary Aldosteronism\/\/Updated: 2018\/- 02. http:\/\/misc.medscape.com\/pi\/iphone\/medscapeapp\/html\/A127080business.html.","key":"ref10"},{"unstructured":"Written by James Norman MD, FACS, FACE. Diseases of the Adrenal Cortex:  Cushing\u2019s Syndrome. The Obesity Tumor https:\/\/www.endocrineweb.com\/conditions\/cushings-syndrome\/diseasesadrenal-cortex-cushings-syndrome.","key":"ref11"},{"doi-asserted-by":"crossref","unstructured":"Young W.F. Conventional imaging in adrenocortical carcinoma: uptade and perspectives. Horm canc 2011; 2: 341\u20137. DOI: 10.1007\/s12672-011-0089-z","key":"ref12","DOI":"10.1007\/s12672-011-0089-z"},{"doi-asserted-by":"crossref","unstructured":"Nwariaku FE, Miller BS, Auchus R et al. Primary hyperaldosteronism: effect of adrenal vein sampling on surgical outcome. Arch Surg 2006; 141: 497\u2013502. DOI: 10.1001\/archsurg.141.5.497","key":"ref13","DOI":"10.1001\/archsurg.141.5.497"},{"unstructured":"Slapa R.Z.1., Jakubowski W., Tyminska B. et al. Progress in imaging diagnostics of adrenal neoplasms. Pol. Merkur. Lekarski. 2000; 8(48): 430\u2013435.","key":"ref14"},{"unstructured":"Alberti C. Adrenal incidentalomas: etiologic diagnostics and basic therapeutic management. A minireview. G. Chir. 2009; 30(5): 243\u2013250.","key":"ref15"},{"doi-asserted-by":"crossref","unstructured":"Hussain H.K., Korobkin M. MR imaging of the adrenal glands. Magn. Reson. Imaging Clin. N. Am. 2004; 12: 515\u2013544. DOI: 10.1016\/j.mric.2004.03.008","key":"ref16","DOI":"10.1016\/j.mric.2004.03.008"},{"unstructured":"Magnetic Resonance Imaging: A Guide for Doctors; Under. ed. G.E. Trufanov and V.A. Fokina. St. Petersburg: Folliant. 2007:526\u2013536.","key":"ref17"},{"doi-asserted-by":"crossref","unstructured":"Ghanem N. CT and MRI in the differential diagnosis of lesions of the adrenal gland \/ N. Ghanem, C. Altehoefer, C. Thurl et al. \/\/ Munich: Med. Klin. 2004. Aug. 15,99(8).P.447\u2013452. DOI: 10.1007\/s00063-004-1054-1","key":"ref18","DOI":"10.1007\/s00063-004-1054-1"},{"doi-asserted-by":"crossref","unstructured":"Domenico Rubello, Chuong Bui, Dario Casara, Milton D Gross, Lorraine M Fig and Brahm Shapiro. Functional scintigraphy of the adrenal gland European Journal of Endocrinology. 2002. 147. 13\u201328.  DOI: 10.1530\/eje.0.1470013","key":"ref19","DOI":"10.1530\/eje.0.1470013"},{"doi-asserted-by":"crossref","unstructured":"Di Martino M, Garcia Sanz I, Munoz de Nova JL, Marin Campos C, Martinez Martin M, Dominguez Gadea L. NP-59 test for preoperative localization of primary hyperaldosteronism. Langenbecks Arch Surg. 2017 Mar; 402(2): 303\u2013308. doi: 10.1007\/s00423-017-1561-1.","key":"ref20","DOI":"10.1007\/s00423-017-1561-1"},{"doi-asserted-by":"crossref","unstructured":"Neville AM, O\u2019Hare MJ. Histopathology of the human adrenal cortex. Clin Endocrinol Metab 14: 791\u2013 820, 1985.","key":"ref21","DOI":"10.1016\/S0300-595X(85)80078-5"},{"doi-asserted-by":"crossref","unstructured":"Lumachi F., Basso S.M., Borsato S. et al. Role and costeffectiveness of adrenal imaging and imageguided FNA cytology in the management of incidentally discovered adrenal tumours. Anticancer Res. 2005; 25 (6C): 4559\u20134562. DOI: 10.1002\/cncr.9047","key":"ref22","DOI":"10.1002\/cncr.9047"},{"doi-asserted-by":"crossref","unstructured":"Saeger W., Fassnacht M., Chita R. et al. High diagnostic accuracy of adrenal core biopsy: results of the German and Austrian adrenal network multicenter trial in 220 consecutive patients. Hum. Pathol. 2003; 34: 180\u2013186. DOI: 10.1053\/hupa.2003.24","key":"ref23","DOI":"10.1053\/hupa.2003.24"},{"doi-asserted-by":"crossref","unstructured":"Scholl UI, Nelson-Williams C, Yue P et al. Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5. Proc Natl Acad Sci USA 2012; 109: 2533\u20138. DOI: 10.1073\/pna.1121407109","key":"ref24","DOI":"10.1073\/pnas.1121407109"},{"doi-asserted-by":"crossref","unstructured":"John W. Funder, Robert M. Carey, Franco Mantero, M. Hassan Murad, Martin Reincke, Hirotaka Shibata, Michael Stowasser, William F. Young, Jr. The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism, Volume 101, Issue 5, 1 May 2016, Pages 1889\u20131916, https:\/\/doi.org\/10.1210\/jc.2015-4061.","key":"ref25","DOI":"10.1210\/jc.2015-4061"},{"doi-asserted-by":"crossref","unstructured":"Choi M, Scholl UI, Yue P, Bj\u00f6rklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ et al. K+ channel mutations in adrenal aldosteroneproducing adenomas and hereditary hypertension. Science 2011 331 768\u2013772. (https:\/\/doi.org\/10.1126\/science.1198785.","key":"ref26","DOI":"10.1126\/science.1198785"},{"doi-asserted-by":"crossref","unstructured":"Litchfield WR, New MI, Coolidge C, et al. Evaluation of the dexamethasone suppression test for the diagnosis of glucocorticoid-remediable aldosteronism. J Clin Endocrinol Metab. 1997 Nov. 82(11):3570\u20133. DOI: 10.1210\/jcem.82.11.4381","key":"ref27","DOI":"10.1210\/jc.82.11.3570"},{"doi-asserted-by":"crossref","unstructured":"Young WF, Stanson AW, Thompson GB et al. Role for adrenal venous sampling in primary aldosteronism. Surgery 2004; 136: 1227\u201335. DOI: 10.1016\/j.surg.2004.06.051","key":"ref28","DOI":"10.1016\/j.surg.2004.06.051"},{"doi-asserted-by":"crossref","unstructured":"Riester A, Fischer E, Degenhart C et al. Age below 40 or a recently proposed clinical prediction score cannot bypass adrenal venous sampling in primary aldosteronism. J Clin Endocrinol Metab 2014; 99: E1035\u20139. doi: 10.1210\/jc.2013-3789.","key":"ref29","DOI":"10.1210\/jc.2013-3789"},{"doi-asserted-by":"crossref","unstructured":"Reardon MA, Angle JF, Abi-Jaoudeh N et al. Intraprocedural cortisol levels in the evaluation of proper catheter placement in adrenal venous sampling. J Vascular Interv Radiol 2011; 22: 1575\u201380. doi: 10.1016\/j.jvir.2011.05.005.","key":"ref30","DOI":"10.1016\/j.jvir.2011.05.005"},{"doi-asserted-by":"crossref","unstructured":"Gordon RD Stowasser MR Utherford JC. Primary aldosteronism: are we diagnosing and operating on too few patients? World Journal of Surgery 2001 25 941\u2013947. (https:\/\/doi.org\/10.1007\/s00268-001-0033-4.","key":"ref31","DOI":"10.1007\/s00268-001-0033-4"},{"doi-asserted-by":"crossref","unstructured":"Satoh F, Morimoto R, Ono Y, Iwakura Y, Omata K, Kudo M, Satani N, Ota H, Seiji K, Takase K, Nakamura Y, Sasano H, Ito S. 8D.04: clinical benefits of administering super-selective segmental adrenal venous sampling and performing adrenal sparing surgery in the patients with primary aldosteronism. J Hypertens. 2015; 33(suppl 1):e114. doi: 10.1097\/01.hjh.0000467658.23414.b0.","key":"ref32","DOI":"10.1097\/01.hjh.0000467658.23414.b0"},{"doi-asserted-by":"crossref","unstructured":"Rossi G.P. Funder J.W. Adrenal vein sampling is the preferred method to select patients with primary aldosteronism for adrenalectomy: pro side of the argument. Hypertension 2018 715\u20139. (https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.117.09295.","key":"ref33","DOI":"10.1161\/HYPERTENSIONAHA.117.09295"},{"doi-asserted-by":"crossref","unstructured":"Williams TA, Reincke M. Management of endocrine disease: Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited. Endocrinol. 2018 Jul;179(1):R19-R29. doi: 10.1530\/EJE-17-0990.","key":"ref34","DOI":"10.1530\/EJE-17-0990"},{"doi-asserted-by":"crossref","unstructured":"Kline G, Leung A, So B, Chin A, Harvey A, Pasieka JL. Application of strict criteria in adrenal venous sampling increases the proportion of missed patients with unilateral disease who benefit from surgery for primary aldosteronism. J Hypertens.  2018 Jun; 36(6): 1407\u20131413. doi: 10.1097\/HJH.0000000000001693.","key":"ref35","DOI":"10.1097\/HJH.0000000000001693"},{"doi-asserted-by":"crossref","unstructured":"Rossi GP, Cesari M, Cuspidi C et al. Long-term control of arterial hypertension and regression of left ventricular hypertrophy with treatment of primary aldosteronism. Hypertension 2013; 62: 62\u20139. doi: 10.1161\/HYPERTENSIONAHA.113.01316.","key":"ref36","DOI":"10.1161\/HYPERTENSIONAHA.113.01316"},{"doi-asserted-by":"crossref","unstructured":"Meyer A, Brabant G, Behrend M. Long-term follow-up after adrenalectomy for primary aldosteronism. World J Surg 2005; 29: 155\u20139. DOI: 10.1007\/s00268-004-7496-z","key":"ref37","DOI":"10.1007\/s00268-004-7496-z"},{"doi-asserted-by":"crossref","unstructured":"Rossi GP, Auchus RJ, Brown M et al. An expert consensus statement on use of adrenal vein sampling for the subtyping of primary aldosteronism. Hypertension 2014; 63: 151\u201360. doi: 10.1161\/HYPERTENSIONAHA.113.02097.","key":"ref38","DOI":"10.1161\/HYPERTENSIONAHA.113.02097"},{"doi-asserted-by":"crossref","unstructured":"Webb R, Mathur A, Chang R et al. What is the best criterion for the interpretation of adrenal vein sample results in patients with primary hyperaldosteronism? Ann Surg Oncol 2012; 19: 1881\u20136. Doi: 10.1245\/s10434-011-2121-5","key":"ref39","DOI":"10.1245\/s10434-011-2121-5"},{"doi-asserted-by":"crossref","unstructured":"Young WF, Stanson AW, Thompson GB et al. Role for adrenal venous sampling in primary aldosteronism. Surgery 2004; 136: 1227\u201335.","key":"ref40","DOI":"10.1016\/j.surg.2004.06.051"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-12-215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T23:03:53Z","timestamp":1640300633000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-12-215.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["JMedLife-12-215"],"URL":"https:\/\/doi.org\/10.25122\/jml-2019-0073","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"type":"print","value":"1844-122X"},{"type":"electronic","value":"1844-3117"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}