{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:33:04Z","timestamp":1769347984525,"version":"3.49.0"},"reference-count":15,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>The management and prognosis of squamous cell carcinoma largely depend on its invasiveness and grade of differentiation. Pigmented nail fold squamous cell carcinoma represents a therapeutic challenge, needing careful treatment to preserve nail function. Here, we report the use of dermoscopy and Reflectance Confocal Microscopy to monitor nail fold squamous cell carcinoma in situ and its response to treatment with topical imiquimod.<\/jats:p>","DOI":"10.25122\/jml-2019-0129","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T07:18:01Z","timestamp":1668755881000},"page":"107-111","source":"Crossref","is-referenced-by-count":3,"title":["Dermoscopy and Reflectance Confocal Microscopy in the Diagnosis and Management of Nail Fold Squamous Cell Carcinoma"],"prefix":"10.25122","volume":"13","author":[{"given":"Sara","family":"Mazzilli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Sara Mazzilli, MD Dermatologic Unit, Department of Systems Medicine University of Rome Tor Vergata Viale Oxford 81 Rome 00133, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terenzio","family":"Cosio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Diluvio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Vollono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Medicine and Medical Divisions, University of Alcal\u00e1, Madrid, Spain.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monia","family":"Di Prete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Anatomic Pathology Unit, University of Rome Tor Vergata, Rome, Italy.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Anatomic Pathology Unit, University of Rome Tor Vergata, Rome, Italy.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Campione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2020,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"1. Lecerf P, Richert B, Theunis A, Andr\u00e9 J. A retrospective study of squamous cell carcinoma of the nail unit diagnosed in a Belgian general hospital over a 15-year period. J Am Acad Dermatol. 2013 Aug; 69 (2): 253-261.","DOI":"10.1016\/j.jaad.2013.02.008"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"2. High WA, Tyring SK, Taylor RS. Rapidly Enlarging Growth of the Proximal Nail Fold. Dermatol Surg. 2003 Sep; 29 (9): 984-986.","DOI":"10.1046\/j.1524-4725.2003.29266.x"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"3. Dika E, Starace M, Patrizi A, Fanti PA, Piraccini BM. Squamous Cell Carcinoma of the Nail Unit: A Clinical Histopathologic Study and a Proposal for Classification. Dermatol Surg. 2019 Mar; 45 (3): 365-370.","DOI":"10.1097\/DSS.0000000000001805"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"4. Starace M, Alessandrini A, Dika E, Piraccini BM. Squamous cell carcinoma of the nail unit. Dermatol Pract Concept. 2018 Jul 31; 8 (3): 238-244.","DOI":"10.5826\/dpc.0803a017"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"5. Manfredini M, Longo C, Ferrari B, et al. Dermoscopic and reflectance confocal microscopy features of cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol. 2017 Nov; 31 (11): 1828-1833.","DOI":"10.1111\/jdv.14463"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"6. Ulrich M, Lange-Asschenfeldt S, Gonzalez S. The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies. Dermatol Pract Concept. 2012 Apr 30; 2 (2): 202a10.","DOI":"10.5826\/dpc.0202a10"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"7. Aldabagh B, Angeles JG, Cardones AR, Arron ST. Cutaneous squamous cell carcinoma and human papillomavirus: is there an association? Dermatol Surg. 2013 Jan; 39 (1 Pt 1): 1-23.","DOI":"10.1111\/j.1524-4725.2012.02558.x"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"8. Ehteram H, Sadat Mousavian M, Mazoochi T, Khamehchian T, Karimian M. Association of Some High-Risk Mucosal Types of Human Papillomavirus with Cutaneous Squamous Cell Carcinoma in an Iranian Population. Iran J Pathol. 2019 Fall; 14 (4): 313-316.","DOI":"10.30699\/IJP.2019.101544.2011"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"9. Handisurya A, Rieger A, Bankier A, et al. Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy. Br J Dermatol. 2007 Oct; 157 (4): 788-794.","DOI":"10.1111\/j.1365-2133.2007.08094.x"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"10. Teoh YL, Kuan LY, Chong WS, Chia HY, Thng TG, Chuah SY. The role of reflectance confocal microscopy in the diagnosis and management of squamous cell carcinoma in situ treated with photodynamic therapy. Int J Dermatol. 2019 Dec; 58 (12): 1382-1387.","DOI":"10.1111\/ijd.14581"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"11. Hanna E, Abadi R, Abbas O. Imiquimod in dermatology: an overview. Int J Dermatol. 2016 Aug; 55 (8): 831-844.","DOI":"10.1111\/ijd.13235"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"12. Campione E, Di Prete M, Del Principe I, et al. Lack of efficacy of imiquimod in patients with basal cell carcinoma previously treated with rituximab for B cell lymphoma: two case reports. J Med Case Rep. 2016 Mar 11; 10:57.","DOI":"10.1186\/s13256-016-0834-6"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"13. Fernandez Figueras MT. From actinic keratosis to squamous cell carcinoma: pathophysiology revisited. J Eur Acad Dermatol Venereol. 2017 Mar; 31 Suppl 2: 5-7.","DOI":"10.1111\/jdv.14151"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"14. Rishpon A, Kim N, Scope A, et al. Reflectance confocal microscopy criteria for squamous cell carcinomas and actinic keratoses. Arch Dermatol. 2009 Jul; 145 (7): 766-772.","DOI":"10.1001\/archdermatol.2009.134"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"15. Peppelman M, Nguyen KP, Hoogendoorn L, van Erp PE, Gerritsen MJ. Reflectance confocal microscopy: non-invasive distinction between actinic keratosis and squamous cell carcinoma. 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