{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:11:22Z","timestamp":1793747482906,"version":"4.6.1"},"reference-count":15,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>The role of the renin-angiotensin system in hypertension and end-organ damage has long been recognized. Angiotensin l converting enzyme inhibitors are superior to other antihypertensive agents in protecting the kidney against progressive deterioration, even in normotensive persons. Likewise, angiotensin II type 1 receptor antagonists improve or even reverse glomerulosclerosis in rat animal models. These findings suggest that Angiotensin II has nonhemodynamic effects in progressive renal disease. The renin-angiotensin system is now recognized to be linked to the induction of plasminogen activator-inhibitor-1, possibly via the AT4 receptor, thus promoting both thrombosis and fibrosis. Interactions of the renin-angiotensin system with aldosterone and bradykinin may impact both blood pressure and tissue injury. The beneficial effect on renal fibrosis of inhibiting the renin-angiotensin system likely reflects the central role that angiotensin has in regulating renal function and structure by its various actions. This article explores the renin-angiotensin-aldosterone system with plasminogen activator-inhibitor-1 interaction and the potential significance of these interactions in the pathogenesis of progressive renal disease and remodeling of renal sclerosis.<\/jats:p>","DOI":"10.25122\/jml-2020-0006","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T07:22:36Z","timestamp":1668756156000},"page":"116-118","source":"Crossref","is-referenced-by-count":2,"title":["Current Trends on Glomerulosclerosis Regression"],"prefix":"10.25122","volume":"13","author":[{"given":"Marilena","family":"Stoian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Clinic of Internal Medicine, Dr.I.Cantacuzino Hospital, Bucharest, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"\u201cCarol Davila\u201d University of Medicine, Bucharest, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Marilena Stoian MD, PhD, 65 Matei Basarab Street, District 3, Bucharest, Romania. E-mail: marilenastoian@yahoo.com","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Stoica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Clinic of Internal Medicine, Dr.I.Cantacuzino Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"\u201cCarol Davila\u201d University of Medicine, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","published-online":{"date-parts":[[2020,4]]},"reference":[{"key":"ref1","unstructured":"1. American Diabetes Association.Standards of medical care for patients with diabetes mellitus.Diabetes Care 2000;23:Si:ppl 1:S32-42."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"2. 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Pusey CP, Rees AJ, Evans DJ: Plasma \u2013exchange in focal necrotizing glomerulonephritis without anti-GBM antibodies.Kidney Int.40: 757-763, 2001.","DOI":"10.1038\/ki.1991.272"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-13-116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T07:22:41Z","timestamp":1668756161000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-13-116.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["JMedLife-13-116"],"URL":"https:\/\/doi.org\/10.25122\/jml-2020-0006","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"value":"1844-122X","type":"print"},{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}