{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:45:39Z","timestamp":1762868739040},"reference-count":20,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>Immunopathogenesis of inflammatory and dystrophic diseases of the tissues of the oral cavity is characterized by cellular and humoral factors of specific and nonspecific resistance, the functioning of which is determined by the overall somatic state.<\/jats:p>\n<jats:p>This study aimed to study the features of protective mechanisms of the oral cavity due to orthodontic pathology, pathology of periodontal tissues, and odontogenic inflammatory process in children with diffuse nontoxic goiter.<\/jats:p>\n<jats:p>Eighty children with diffuse nontoxic goiter aged 12-15 years with different dental status were examined. Evaluation of local immunity of the oral cavity was carried out by determining the content of sIgA, IgA, IgG, lysozyme activity, and levels of IL-1\u03b2, IL-4 by enzyme immunoassay.<\/jats:p>\n<jats:p>Immunological studies have shown that in children with diffuse nontoxic goiter, the activity of lysozyme in the oral fluid is decreased.<\/jats:p>\n<jats:p>The level of sIg\u0410 is also reduced by about 20%. Besides, there is an increase in the content of IgG and a growing trend in the level of Ig\u0410. The content of IL-1\u03b2 and IL-4 in such children fluctuates more compared to somatically healthy children.<\/jats:p>\n<jats:p>In conclusion, a violation of the local protective mechanisms of the oral cavity is observed in children with diffuse nontoxic goiter. Also, the increase in the severity of dental pathology leads to increased tension of local protective and compensatory reactions.<\/jats:p>","DOI":"10.25122\/jml-2020-0013","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T04:55:53Z","timestamp":1642308953000},"page":"21-25","source":"Crossref","is-referenced-by-count":11,"title":["The Influence of Diffuse Nontoxic Goiter on the State of Protective Mechanisms of the Oral Cavity in Children"],"prefix":"10.25122","volume":"13","author":[{"given":"Oksana Ivanivna","family":"Godovantes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pediatric Dentistry, Higher State Educational Establishment of Ukraine, \u201cBukovinian State Medical University\u201d, Chernivtsi, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Oksana Ivanivna Godovantes Head of the Department of Pediatric Dentistry, Higher State Educational Establishment of Ukraine \u201cBukovinian State Medical University\u201d, Chernivtsi, Ukraine Theater Square, 2, Chernivtsi, Ukraine 58002 E-mail: godovanec.oleksij@bsmu.edu.ua Phone: +380505606138","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetiana Stepanivna","family":"Kitsak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pediatric Dentistry, Higher State Educational Establishment of Ukraine, \u201cBukovinian State Medical University\u201d, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr Oleksandrovich","family":"Vitkovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pediatric Dentistry, Higher State Educational Establishment of Ukraine, \u201cBukovinian State Medical University\u201d, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyudmyla Vasylivna","family":"Kuzniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Surgical Dentistry and Maxillofacial Surgery, Higher State Educational Establishment of Ukraine, \u201cBukovinian State Medical University\u201d, Chernivtsi, Ukraine.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksii Serhiyovych","family":"Godovantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pediatrics, Neonatology and Perinatal Medicine, Higher State Educational Establishment of Ukraine \u201cBukovinian State Medical University\u201d, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia Mykhaylivna","family":"Chaikovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Foreign Languages, Higher State Educational Establishment of Ukraine, \u201cBukovinian State Medical University\u201d, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa Yaroslavivna","family":"Fedoniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Medical Biology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2020,1]]},"reference":[{"key":"ref1","unstructured":"1. Khomenko LO. \u041estapko \u041eI. Bidenko NV. et al. General health status influence on stomatological diseases of children and teenagers. Medical Science of Ukraine 2016;12(12):58-63. (Ukr)."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"2. Mejare IA. Klingberg G. Mowafi FK. et al. A systematic map of systematic reviews in pediatric dentistry \u2013 what do we really know. PLoS One. 2015;10(2):e0117537.","DOI":"10.1371\/journal.pone.0117537"},{"key":"ref3","unstructured":"3. Nazir MA. Prevalence of periodontal disease. its association with systemic diseases and prevention. Int J Healht Sci (Qassim). 2017;11(2):72-80."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"4. Winning L. Linder GJ. 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