{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:29:13Z","timestamp":1787992153655,"version":"build-2784847793"},"reference-count":23,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>Candidal vaginitis has a relatively high prevalence, and its resistance to treatment is on the rise. Considering the complications of chemical drugs, the use of herbal medicines has now been favored due to the lack of changes in the normal vaginal flora. The aim of this study was to compare the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of candidal vulvovaginitis. A randomized clinical trial was conducted on 84 reproductive-aged women in the city of Ahvaz, Iran. Individuals were randomly divided into two treatment groups: 1% Satureja khuzestanica vaginal creams (n=42) and 1% clotrimazole vaginal cream (n=42) who used a one-full applicator daily for one week. About 4\u20137 days after the end of treatment, a clinical examination and laboratory re-tests were performed to determine the level of treatment. The data were analyzed using the Mann-Whitney U, t-test and Chi-square tests, with SPSS version 22. After the treatment, no significant difference was observed between the two groups in terms of vaginal discharge (p = 0.32), vaginal itching (p = 0.26), dysuria (p = 0.99) and dyspareunia (p = 0.60). Moreover, the results of culture (p = 0.62) and smear (p = 0.58) were not statistically significant in the two groups. Also, there was no significant difference between the two groups in terms of complete recovery after the treatment (p = 0.35). Satureja khuzestanica seems to have the same effect as clotrimazole in improving the symptoms of vaginal candidiasis, the negative results of culture and smear, as well as complete treatment.<\/jats:p>","DOI":"10.25122\/jml-2020-0014","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T09:05:22Z","timestamp":1618563922000},"page":"111-117","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the effectiveness of<b>Satureja khuzestanica<\/b>and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis"],"prefix":"10.25122","volume":"14","author":[{"given":"Mahnaz","family":"Fatahinia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Jaldani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Maraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Biostatistics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eskandar","family":"Moghimipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Javadnoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Midwifery, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"* Corresponding Author: Mojgan Javadnoori, Department of Midwifery, School of Nursing and Midwifery, Ahvaz Jundishpaur University of Medical Sciences, Ahvaz, Iran. E-mail: mojganjavadnoori@gmail.com","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","published-online":{"date-parts":[[2021,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"1. Vicariotto F, Del Piano M, Mogna L, Mogna G. Effectiveness of the association of 2 probiotic strains formulated in a slow release vaginal product, in women affected by vulvovaginal candidiasis: a pilot study. Journal of clinical gastroenterology. 2012;46:S73\u2013S80.","DOI":"10.1097\/MCG.0b013e3182684d71"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"2. Bornstein J, Zarfati D. A universal combination treatment for vaginitis. Obstetrical & Gynecological Survey. 2008;63(9):570\u2013571.","DOI":"10.1097\/01.ogx.0000326442.57422.0c"},{"key":"ref3","unstructured":"3. Buitr\u00f3n RG, Romero RC, Cruz FT, Bonifaz A, Zarama FM. Study on Candida no-albicans species and its relation to recurrent vulvovaginal candidiasis. Ginecologia y obstetricia de Mexico. 2002;70:431\u2013436."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"4. Sobel JD. Vulvovaginal candidosis. The Lancet. 2007;369(9577):1961\u20131971.","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"5. Weissenbacher T, Witkin S, Ledger W,et al.Relationship between clinical diagnosis of recurrent vulvovaginal candidiasis and detection of Candida species by culture and polymerase chain reaction. Archives of gynecology and obstetrics. 2009;279(2):125\u2013129.","DOI":"10.1007\/s00404-008-0681-9"},{"key":"ref6","unstructured":"6. Vakili L, Jafarpur M. The Determination of vaginal candidiasis inwomen referred to Shahid Rajaei hospital in tonekabon (2009\u20132010). Medical Laboratory Journal. 2011;5(1):1\u20137."},{"key":"ref7","unstructured":"7. Sehhatie-Shafaie F, Namazi A. Prevalence, risk factors, and clinical findings of candidiasis and trichomoniasis in women supported by selected health centers of Tabriz, Iran. Crescent Journal of Medical and Biological Sciences. 2014;1(4):130\u2013135."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"8. Mtibaa L, Fakhfakh N, Kallel A,et al.Vulvovaginal candidiasis: Etiology, symptomatology and risk factors. Journal de mycologie medicale. 2017;27(2):153\u2013158.","DOI":"10.1016\/j.mycmed.2017.01.003"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"9. Grigoriou O, Baka S, Makrakis E, Hassiakos D, Kapparos G, Kouskouni E. Prevalence of clinical vaginal candidiasis in a university hospital and possible risk factors. European journal of obstetrics & gynecology and reproductive biology. 2006;126(1):121\u2013125.","DOI":"10.1016\/j.ejogrb.2005.09.015"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"10. Mendling W, Brasch J. Guideline vulvovaginal candidosis (2010) of the German society for gynecology and obstetrics, the working group for infections and infectimmunology in gynecology and obstetrics, the German society of dermatology, the board of German dermatologists and the German speaking mycological society. Mycoses. 2012;55:1\u201313.","DOI":"10.1111\/j.1439-0507.2012.02185.x"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"11. Kane JM, Brannen M, Kern E. Impact of patient safety mandates on medical education in the United States. Journal of Patient Safety. 2008;4(2):93\u201397.","DOI":"10.1097\/PTS.0b013e318173f7b5"},{"key":"ref12","unstructured":"12. Bahadoran P, Rokni FK, Fahami F. Investigating the therapeutic effect of vaginal cream containing garlic and thyme compared to clotrimazole cream for the treatment of mycotic vaginitis. Iranian journal of nursing and midwifery research. 2010;15(Suppl1):343."},{"key":"ref13","unstructured":"13. Kangongo M, Wanyoike W, Revathi G, Wakibia J, Bii C. Emerging azole resistance among Candida albicans from clinical sources in Nairobi, Kenya. Journal of Agriculture, Science and Technology. 2012;13(2)."},{"key":"ref14","unstructured":"14. Sheidaei S, Jaafarnejad F, Najafzadeh M, Rajabi O, Sadeghi T, Dadgar S. Comparison of the Effect of Vaginally Administered Coconut Oil and Clotrimazole on Candida Species. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2018;20(12):58\u201366."},{"key":"ref15","unstructured":"15. Abbasi K, Sefidkon F, Yamini Y. Comparison of oil content and composition of two satureja species (S. Hortensis l, and S. Rechingerijamzad) by hydrodistillation and supercritical fluid extrection (SFE). 2005. 2005;21(3):307."},{"key":"ref16","unstructured":"16. Teymuri A, Bokaeian M. Antimicrobial effect of extracts of Satureja hortensis biofilm on some important human bacterial pathogens. Razi Journal of Medical Sciences. 2017;23(152):38\u201345."},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"17. Jafari F, Ghavidel F, Zarshenas MM. A critical overview on the pharmacological and clinical aspects of popular Satureja species. Journal of acupuncture and meridian studies. 2016;9(3):118\u2013127.","DOI":"10.1016\/j.jams.2016.04.003"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"18. Mahboubi M, Attaran B. Satureja khuzistanica Jamzad essential oil and its anti-candidal activities against clinical isolates of Candida albicans isolated from women with candidiasis. Infectio. 2019;23(1):16\u201321.","DOI":"10.22354\/in.v23i1.750"},{"key":"ref19","unstructured":"19. Jafarzadeh L, Separdar A, Lori Gavini Z, Rafiean M, Deris F, Shahinfard N. Effect of Clotrimazole-Satureja Bachtiarica Vaginal Cream and Clotrimazole Vaginal Cream in Patients with Vaginal Candidiasis. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2019;21(11):14\u201322."},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"20. Shabanian S, Khalili S, Lorigooini Z, Malekpour A, Heidari-Soureshjani S. The effect of vaginal cream containing ginger in users of clotrimazole vaginal cream on vaginal candidiasis. Journal of advanced pharmaceutical technology & research. 2017;8(2):80.","DOI":"10.4103\/japtr.JAPTR_176_16"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"21. Darvishi M, Jahdi F, Hamzegardeshi Z, Goodarzi S, Vahedi M. The Comparison of vaginal cream of mixing yogurt, honey and clotrimazole on symptoms of vaginal candidiasis. Global journal of health science. 2015;7(6):108.","DOI":"10.5539\/gjhs.v7n6p108"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"22. Farshbaf-Khalili A, Mohammadi-Ghalehbin B, Shahnazi M, Asghari S, Javadzadeh Y, Azghani P. Comparing the effect of garlic, Zataria multiflora and Clotrimazole vaginal cream 2% on improvement of fungal vaginitis: a randomized controlled trial. Iranian Red Crescent Medical Journal. 2016;18(12).","DOI":"10.5812\/ircmj.29262"},{"key":"ref23","unstructured":"23. Naeini A, Naseri M, Kamalinejad M,et al.Study on Anti_ Candida Effects of Essential Oil and Extracts of Iranian Medicinal Plants, In vitro. Journal of Medicinal Plants. 2011;2(38):163\u2013172."}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/19.-jml-2020-0014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T14:11:33Z","timestamp":1724854293000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/19.-jml-2020-0014.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["JMedLife-14-111"],"URL":"https:\/\/doi.org\/10.25122\/jml-2020-0014","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"value":"1844-122X","type":"print"},{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}