{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:32:07Z","timestamp":1759332727361},"reference-count":22,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>The study of the pathogenetic treatment and prevention of Helicobacter pylori (Hp)-associated gastroduodenopathies (GDP) induced by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis (OA) is one of the most serious problems in modern clinical medicine. Sixty patients with OA and concomitant Hp-associated GDP induced by NSAIDs were examined. The levels of epidermal growth factor (EDF), sAPO-1\/Fas and tumor necrosis factor-\u03b1 (TNF-\u03b1) were determined. Group I included 30 patients who received triple anti-Helicobacter (AHT) therapy, and group II included 30 patients who received rebamipide. Long-term effects were assessed 6 months and 1 year after treatment. All subjects showed a significant increase in TNF-\u03b1 (4.7 times), EDF (2.2 times) and a decrease in sAPO-1\/Fas (3.6 times) levels compared to healthy individuals. After 1 month of treatment, a significantly more significant decrease in TNF-\u03b1 and an increase in sAPO-1\/Fas and EDF was found in group II. In the long-term treatment, a further decrease in TNF-\u03b1 and an increase in the content of sAPO-1\/Fas levels were observed in all groups. However, these changes were significantly more significant in group I compared to group I. The long-term follow-up showed a declining trend of EDF in all groups. The data obtained indicate the effectiveness of rebamipide in the complex pathogenetic treatment and prevention of Hp-associated GDP induced by NSAIDs in patients with OA.<\/jats:p>","DOI":"10.25122\/jml-2020-0176","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T09:45:07Z","timestamp":1634118307000},"page":"176-180","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of long-term results of pathogenetic treatment of Helicobacter pylori-associated gastroduodenopathies induced by nonsteroidal anti-inflammatory drugs in patients with osteoarthritis"],"prefix":"10.25122","volume":"14","author":[{"given":"Ludmila Mykhailivna","family":"Honcharuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine and Infectious Disease, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"* Corresponding Author: Ludmila Mykhailivna Honcharuk, Department of Internal Medicine and Infectious Disease, Bukovinian State Medical University, Chernivtsi, Ukraine. 125A Prospekt Nezalezhnosti., ap. 114, 58029, Chernivtsi, Ukraine. Phone: +380505381456. E-mail: ludmylahoncharuk@gmail.com","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine and Infectious Disease, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine and Infectious Disease, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine and Infectious Disease, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olexander Ivanovicha","family":"Fediv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svitlana Oleksandrivna","family":"Hresko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Gastroenterology, Municipal institution Regional Clinical Hospital, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina Anatoliivna","family":"Piddubna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Clinical Immunology, Allergology and Endocrinology, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila Viktorivna","family":"Mikulets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Propaedeutics of Internal Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona Tarasivna","family":"Rusnak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine, Physical Rehabilitation and Sports Medicine, Bukovynian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro Olexandrovich","family":"Hontsariuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliia Valeriievna","family":"Kokhaniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2021,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Allen KD, Choong PF, Davis AM, Dowsey MM, Dziedzic KS, Emery C, et al. OA: Models for appropriate care across the disease continuum. Best Pract Res Clin Rheumatol. 2016;30(3):503\u2013535. doi: 10.1016\/j.berh.2016.09.003 PMID: 27886944 [PubMed].","DOI":"10.1016\/j.berh.2016.09.003"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Crofford LJ. Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther. 2013;15(3):2. doi:10.1186\/ar4174 PMID: 24267197 [PMC free article] [PubMed] [CrossRef] [Google Scholar].","DOI":"10.1186\/ar4174"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Lapane KL, Yang S, Driban JB, Liu S, Dube CE, McAlindon TE, Eaton CB. Effects of prescription non-steroidal anti-inflammatory agents on symptoms and disease progression among patients with knee osteoarthritis. Arthritis Rheumatol. 2015;67(3): 724\u2013732. doi: 10.1002\/art.38933 PMID: 25369996 [PMC free article] [PubMed] [CrossRef] [Google Scholar].","DOI":"10.1002\/art.38933"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Melcarne L, Garc\u00eda-Iglesias P, Calvet X. Management of NSAID-associated peptic ulcer disease. Expert Rev Gastroenterol Hepatol. 2016;10(6):723\u201333. doi: 10.1586\/17474124.2016.1142872 PMID: 26775657.","DOI":"10.1586\/17474124.2016.1142872"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Bruyere O, Cooper C, Pelletier JP, Maheu E, Rannou F, Branco J, Brandi ML, et al. A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis \u2013 From evidence-based medicine to the real-life setting. Semin Arthritis Rheum. 2016;45(4Suppl):3\u201311. doi: 10.1016\/j.semarthrit.2015.11.010 PMID: 26806188.","DOI":"10.1016\/j.semarthrit.2015.11.010"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Hunt R, Lazebnik LB, Marakhouski YC, Manuc M, Ramesh GN, Aye KS, et al. International Consensus on Guiding Recommendations for Management of Patients with Nonsteroidal Antiinflammatory Drugs Induced Gastropathy-ICON-G. Euroasian J Hepatogastroenterol. 2018;8(2):148\u2013160. doi: 10.5005\/jp-journals-10018-1281 PMID: 30828557.","DOI":"10.5005\/jp-journals-10018-1281"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Bielsa-Fern\u00e1ndez MV, Tamayo-de la Cuesta JL, Liz\u00e1rraga-L\u00f3pez J, Remes-Troche JM, Carmona-S\u00e1nchez R, Aldana-Ledesma JM, et al. Consenso mexicano sobre diagn\u00f3stico, prevenci\u00f3n y tratamiento de la gastropat\u00eda y enteropat\u00eda por antiinflam-atorios no esteroideos. Revista de Gastroenterolog\u00eda de M\u00e9xico.2020;85:190\u2013206. doi: 10.1016\/j.rgmxen.2019.11.001.","DOI":"10.1016\/j.rgmx.2019.11.003"},{"key":"ref8","unstructured":"Meng W, Bai B, Sheng L, Li Y, Yue P, Li X, Qiao L, et al. Role of Helicobacter Pylori in Gastric Cancer: Advances and Controversies. Discov med.2015;20(111):285\u2013293. PMID: 26645900 [PubMed] [Google Scholar]."},{"key":"ref9","unstructured":"Aruin LI. The quality of healing of gastroduodenal ulcers: functional morphology, the role of pathogenetic therapy methods. Suchas gastroenterology. 2015; 5(73): 92\u2013103. [in Russian]. Available at: http:\/\/nbuv.gov.ua\/UJRN\/SGastro_2013_5_16"},{"key":"ref10","unstructured":"Ostanin AA, Paltsev AI, Lebedev AG, Nikonov SD, Vasil`chenkov AV, Leplina OYU. Characteristic of apoptosis and the functional activity of lymphocytes in patients with peptic ulcer disease. Bulletin of the Siberian branch of the Russian Academy of Medical Sciences. 2004;111(1):129\u2013134. [in Russian]. Available at: https:\/\/cyberleninka.ru\/article\/n\/harakteristika-apoptoza-i-funktsionalnoy-aktivnosti-limfotsitov-u-bolnyh-yazvennoy-boleznyu"},{"key":"ref11","unstructured":"Stepchenko AA, Filippenko NG, Pribylova NN, Povetkin SV. The level of pro-and antiinflammatory cytokines, the phenotype of oxidative metabolism in patients with peptic ulcer disease associated with different strains of Helicobacter pylori. Kurskiy nauchno-pprakticheskiy vestnik \u201cChelovek i ego zdorov`e\u201d. 2010:3;134\u2013139. [in Russian]. Available at: https:\/\/cyberleninka.ru\/article\/n\/uroven-proi-protivovospalitelnyh-tsitokinov-fenotip-okislitelnogo-metabolizma-u-bolnyh-yazvennoy-boleznyu-assotsiirovannoy-s"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Matveeva LV, Stenina MA, Mosina LM. Cytokine regulation of ulcerogenesis in gastroduodenal mucosa. Medical Immunology (Russia). 2013;15(2):107\u2013118. [in Russian]. https:\/\/doi.org\/10.15789\/1563-0625-2013-2-107-118","DOI":"10.15789\/1563-0625-2013-2-107-118"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Chang X, Wang L, Wang Z, Wu S, Zhu X, Hu S, Wang Y, Yu J, et al. TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3. Sci Rep.2017; 7:16111. https:\/\/doi.org\/10.1038\/s41598-017-16390-6 PMID: 29170425 [PMC] - [PubMed].","DOI":"10.1038\/s41598-017-16390-6"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Chow YY, Chin K. The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediators of Inflammation.2020;3:1\u201319. doi: 10.1155\/2020\/8293921 PMID: 32189997 [PMC free article] [PubMed] [CrossRef] [Google Scholar].","DOI":"10.1155\/2020\/8293921"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Qu R, Chen X, Wang W, et al. Ghrelin protects against osteoarthritis through interplay with Akt and NF-kappaB signaling pathways. FASEB J. 2018; 32 (2):1044\u20131058 doi: 10.1096\/fj.201700265R PMID: 29070587.","DOI":"10.1096\/fj.201700265R"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Takahashi-Kanemitsu A, Knight CT, Hatakeyama M. Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis. Cell. Mol. Immunol. 2020;17:50\u201363. doi: 10.1038\/s41423-019-0339-5 [PMC free article] [PubMed] [CrossRef] [Google Scholar].","DOI":"10.1038\/s41423-019-0339-5"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"M\u00fcller SA, Pernitzsch SR, Haange SB, Uetz P, von Bergen M, Sharma CM, Kalkhof S. Stable isotope labeling by amino acids in cell culture based proteomics reveals differences in protein abundances between spiral and coccoid forms of the gastric pathogen Helicobacter pylori. J Proteomics. 2015;126:34\u201345. doi:10.1016\/j.jprot.2015.05.011 PMID: 25979772.","DOI":"10.1016\/j.jprot.2015.05.011"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Sinha M, Gautam L, Shukla PK, Kaur P, Sharma S, Singh TP. Current perspectives in NSAID-induced gastropathy. Mediators Inflamm. 2013;11. doi: 10.1155\/2013\/258209 PMID: 23576851 [PMC free article] [PubMed] [CrossRef] [Google Scholar].","DOI":"10.1155\/2013\/258209"},{"key":"ref19","unstructured":"Mih\u0430ylus\u043ev RN. Growth factors \u2013 advanced technology impact wound healing process. Kharkovskaya khirurgichsekaya shkola. 2014;5(68):90\u201398. [in Ukrainian]. Available at: http:\/\/nbuv.gov.ua\/UJRN\/Khkhsh_2014_5_19"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Liu TL, Maio JC, Sheng WH, Wei-hua Sheng, Xie YF, Huang Q, Shan YB, et al. Cytocompatibility of regenerated silk fibroin film: a medical biomaterial applicable to wound healing. J Zhejiang Univ Sci B. 2010;1:10\u201316 doi: 10.1631\/jzus.B0900163 PMID: 20043346 [PMC free article] [PubMed] [CrossRef] [Google Scholar].","DOI":"10.1631\/jzus.B0900163"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Maity P, Bindu S, Choubey V, Alam A, Mitra K, Goyal M, Dey S, Guha M, Pal C, Bandyopadhyay U.J Withdrawal: Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal. Biol Chem. 2019;294(52):20260. doi: 10.1074\/jbc.W119.012034.PMID: 31882521.","DOI":"10.1074\/jbc.W119.012034"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Arakawa T, Higuchi K, Fujiwara Y, Watanabe T, Tominaga K, Sasaki E, Oshitani N, Yo-shikawa T, Tarnawski AS. 15-th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. Dig. Dis. Sci. 2005;50(1):3\u201311. doi: 10.1007\/s10620-005-2800-9. PMID: 16184418 [PubMed].","DOI":"10.1007\/s10620-005-2800-9"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/8.-jml-2020-0176.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T09:47:44Z","timestamp":1634118464000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/8.-jml-2020-0176.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["JMedLife-14-176"],"URL":"https:\/\/doi.org\/10.25122\/jml-2020-0176","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"type":"print","value":"1844-122X"},{"type":"electronic","value":"1844-3117"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}