{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:04:15Z","timestamp":1768543455252,"version":"3.49.0"},"reference-count":17,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>The effectiveness of pulmonary rehabilitation (PR) has not yet been established in patients with asthma \u2013 chronic obstructive pulmonary disease overlap (ACO) depending on their nutritional status. We aimed to evaluate the effectiveness of a short-term PR program in patients with comorbid asthma, chronic obstructive pulmonary disease (COPD), and obesity. We included 40 ACO patients and divided them into 3 groups according to body mass index (BMI) and then subdivided them into PR (n=21) and control (n=19) groups. The COPD Assessment Test (CAT), the Asthma Control Test (ACT), and the modified Medical Research Council dyspnea scale (mMRS) were used to evaluate symptoms levels. BODE index (body mass index, forced expiratory volume in one second, dyspnoea, and 6-min walk distance) was used to evaluate the effectiveness of pulmonary rehabilitation. In addition, spirometry and bioimpedansometry were performed. All measurements were done before and after a 6-month PR program. A significantly lower decline in the BODE index was observed in overweight patients (decreased by 43.6% compared to baseline and lower by 40.7% compared to the control group). The six-minute walking test (6MWT) significantly increased in all groups (p&lt;0.001). There was a decrease in total CAT score by 25.4% and by 31.2% in the overweight group (p&lt;0.001). The BMI decreased more in the obese group (by 9.4% compared to baseline). Our study result showed that early use of PR program significantly improves functional capacity and BODE index, leads to dyspnea and CAT scores reduction and improvement in pulmonary function, cause a decrease in BMI, body fat percentage, and visceral fat level, and an increase in muscle mass in overweight and obese patients with ACO.<\/jats:p>","DOI":"10.25122\/jml-2021-0050","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T16:44:05Z","timestamp":1668789845000},"page":"196-201","source":"Crossref","is-referenced-by-count":2,"title":["The effectiveness of short-term pulmonary rehabilitation program in patients with comorbid asthma, chronic obstructive pulmonary disease and obesity"],"prefix":"10.25122","volume":"15","author":[{"given":"Olha","family":"Huivaniuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Propaedeutic of Internal Diseases, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Olha Huivaniuk, Department of Propaedeutic of Internal Diseases, Bukovinian State Medical University, Chernivtsi, Ukraine. E-mail: olyanesterovska11@gmail.com https:\/\/orcid.org\/0000-0002-9856-3711","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Stupnytska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Propaedeutic of Internal Diseases, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Fediv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine and Infectious Diseases, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriy","family":"Bocharov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2022,2]]},"reference":[{"key":"ref1","unstructured":"1. Global Initiative for Asthma. Global strategy for Asthma Management and Prevention, 2020. Available from: https:\/\/ginasthma.org\/"},{"key":"ref2","unstructured":"2. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2021 report. Available from https:\/\/goldcopd.org\/"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"3. Cosio BG, Dacal D, Perez de Llano L. Asthma-COPD overlap: identification and optimal treatment. Therapeutic Advances in Respiratory Disease 2018;12:1753466618805662. doi: 10.1177\/1753466618805662.","DOI":"10.1177\/1753466618805662"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"4. Menezes AMB, Montes de Oca M, P\u00e9rez-Padilla R, Nadeau G, et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. 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Available from: http:\/\/ginasthma.org\/download\/824\/"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"14. Lingner H, Ernst S, Gro\u03b2hennig A, Djahangiri N, et al. Asthma control and health-related quality of life one year after inpatient pulmonary rehabilitation: the ProKAR Study. J Asthma 2015;52(6):614-621. doi: 10.3109\/02770903.2014.996650.","DOI":"10.3109\/02770903.2014.996650"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"15. Celli BR, Cote CG, Marin JM, Casanova C, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004 March 4;350(10):1005-12. doi: 10.1056\/NEJMoa021322.","DOI":"10.1056\/NEJMoa021322"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"16. Barreiro E, Jaitovich A. Muscle atrophy in chronic obstructive pulmonary disease: molecular basis and potential therapeutic targets. 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Chest. 2018;153(3):702-709. doi: 10.1016\/j.chest.2017.07.010.","DOI":"10.1016\/j.chest.2017.07.010"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-15-196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T16:44:17Z","timestamp":1668789857000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-15-196.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["JMedLife-15-196"],"URL":"https:\/\/doi.org\/10.25122\/jml-2021-0050","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"value":"1844-122X","type":"print"},{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}