{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:45:39Z","timestamp":1782927939344,"version":"3.54.5"},"reference-count":26,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"3","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>Accreta placenta spectrum is a complex obstetrical condition of abnormal placental invasion associated with severe maternal morbidity. This study aimed to analyze our therapeutic management and counseling of the cases with placenta accreta spectrum (PAS) associated with placenta previa. We performed a retrospective study of pregnant women with PAS associated with placenta previa at the Filantropia Clinical Hospital between January 2017\u2013April 2021. In these cases, the earlier diagnosis was realized by an ultrasonographic scan and was confirmed by histopathological findings after the surgical treatment. The conservative management was obtained in one case at &lt;37 weeks of gestation, and the maternal outcome was uterine preservation. Among the 12 patients, the mean age was 34\u00b13.44 years. All women had risk factors for abnormally invasive placenta, such as placenta previa or previous cesarean delivery. Most women underwent planned cesarean delivery at the mean gestational age of 36.4\u00b10.9 weeks. In our study, the uterus was preserved in only one case (8.33%), and hysterectomy with preservation of ovaries was performed in the rest of the cases. Mean maternal blood loss during surgery was 2175\u00b11440 ml. Severe maternal outcomes were recorded only in one case (8.33%). We identified a low uterine preservation rate and a good perinatal outcome. Conservative management should be reserved for fertility desire and extensive disease due to surgical difficulty. Early identification of the risk factors and strategic management may improve maternal and fetal outcomes.<\/jats:p>","DOI":"10.25122\/jml-2021-0134","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T06:03:13Z","timestamp":1634277793000},"page":"367-375","source":"Crossref","is-referenced-by-count":8,"title":["Maternal and fetal outcome in placenta accreta spectrum (PAS) associated with placenta previa: a retrospective analysis from a tertiary center"],"prefix":"10.25122","volume":"14","author":[{"name":"Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, Bucharest, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynaecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Valentin Nicolae Varlas, Department of Obstetrics and Gynaecology, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu St., 020021, Bucharest, Romania. E-mail: valentin.varlas@umfcd.ro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin Nicolae","family":"Varlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana Georgiana","family":"Bors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Birsanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Maxim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Clotea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mihailov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Eshkoli T, Weintraub AY, Sergienko R, Sheiner E (2013) Placenta accreta: risk factors, perinatal outcomes, and consequences for subsequent births. Am J Obstet Gynecol 208:219.e1\u20137. https:\/\/doi.org\/10.1016\/j.ajog.2012.12.037","DOI":"10.1016\/j.ajog.2012.12.037"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Jauniaux E, Ayres-de-Campos D, Langhoff-Roos J, et al (2019) FIGO classification for the clinical diagnosis of placenta accreta spectrum disorders. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet 146:20\u201324. https:\/\/doi.org\/10.1002\/ijgo.12761","DOI":"10.1002\/ijgo.12761"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Jauniaux E, Alfirevic Z, Bhide AG, et al (2019) Placenta Praevia and Placenta Accreta: Diagnosis and Management: Green-top Guideline No. 27a. BJOG Int J Obstet Gynaecol 126:e1\u2013e48. https:\/\/doi.org\/10.1111\/1471-0528.15306","DOI":"10.1111\/1471-0528.15306"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine (2018) Obstetric Care Consensus No. 7: Placenta Accreta Spectrum. Obstet Gynecol 132:e259\u2013e275. https:\/\/doi.org\/10.1097\/AOG.0000000000002983","DOI":"10.1097\/AOG.0000000000002983"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Jauniaux E, Gr\u00f8nbeck L, Bunce C, et al (2019) Epidemiology of placenta previa accreta: a systematic review and meta-analysis. BMJ Open 9:e031193. https:\/\/doi.org\/10.1136\/bmjopen-2019-031193","DOI":"10.1136\/bmjopen-2019-031193"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Collins SL, Alemdar B, van Beekhuizen HJ, et al (2019) Evidence-based guidelines for the management of abnormally invasive placenta: recommendations from the International Society for Abnormally Invasive Placenta. Am J Obstet Gynecol 220:511\u2013526. https:\/\/doi.org\/10.1016\/j.ajog.2019.02.054","DOI":"10.1016\/j.ajog.2019.02.054"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Jauniaux E, Bunce C, Gr\u00f8nbeck L, Langhoff-Roos J (2019) Prevalence and main outcomes of placenta accreta spectrum: a systematic review and meta-analysis. Am J Obstet Gynecol 221:208\u2013218. https:\/\/doi.org\/10.1016\/j.ajog.2019.01.233","DOI":"10.1016\/j.ajog.2019.01.233"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Jauniaux E, Bhide A, Kennedy A, et al (2018) FIGO consensus guidelines on placenta accreta spectrum disorders: Prenatal diagnosis and screening,. Int J Gynecol Obstet 140:274\u2013280. https:\/\/doi.org\/10.1002\/ijgo.12408","DOI":"10.1002\/ijgo.12408"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Previous Cesarean Delivery and Risks of Placenta Previa and Placental Abruption. Obstet Anesth Dig (2006) 26:138\u2013139","DOI":"10.1097\/00132582-200609000-00040"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Jauniaux E, Chantraine F, Silver RM, Langhoff-Roos J (2018) FIGO consensus guidelines on placenta accreta spectrum disorders: Epidemiology,. Int J Gynecol Obstet 140:265\u2013273. https:\/\/doi.org\/10.1002\/ijgo.12407","DOI":"10.1002\/ijgo.12407"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Roberge S, Chaillet N, Boutin A, et al (2011) Single- versus double-layer closure of the hysterotomy incision during cesarean delivery and risk of uterine rupture. Int J Gynecol Obstet 115:5\u201310. https:\/\/doi.org\/10.1016\/j.ijgo.2011.04.013","DOI":"10.1016\/j.ijgo.2011.04.013"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Dodd JM, Anderson ER, Gates S, Grivell RM (2014) Surgical techniques for uterine incision and uterine closure at the time of caesarean section. Cochrane Database Syst Rev CD004732. https:\/\/doi.org\/10.1002\/14651858.CD004732.pub3","DOI":"10.1002\/14651858.CD004732.pub3"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Yu FNY, Leung KY (2021) Antenatal diagnosis of placenta accreta spectrum (PAS) disorders. Best Pract Res Clin Obstet Gynaecol 72:13\u201324. https:\/\/doi.org\/10.1016\/j.bpobgyn.2020.06.010","DOI":"10.1016\/j.bpobgyn.2020.06.010"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Jha P, P\u014dder L, Bourgioti C, et al (2020) Society of Abdominal Radiology (SAR) and European Society of Urogenital Radiology (ESUR) joint consensus statement for MR imaging of placenta accreta spectrum disorders. Eur Radiol 30:2604\u20132615. https:\/\/doi.org\/10.1007\/s00330-019-06617-7","DOI":"10.1007\/s00330-019-06617-7"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Jha P, Rabban J, Chen L-M, et al (2019) Placenta accreta spectrum: value of placental bulge as a sign of myometrial invasion on MR imaging. Abdom Radiol N Y 44:2572\u20132581. https:\/\/doi.org\/10.1007\/s00261-019-02008-0","DOI":"10.1007\/s00261-019-02008-0"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Philips J, Gurganus M, DeShields S, et al (2019) Prevalence of Sonographic Markers of Placenta Accreta Spectrum in Low-Risk Pregnancies. Am J Perinatol 36:733\u2013780. https:\/\/doi.org\/10.1055\/s-0038-1676488","DOI":"10.1055\/s-0038-1676488"},{"key":"ref17","unstructured":"Shepherd AM, Mahdy H (2021) Placenta Accreta. In: StatPearls. StatPearls Publishing, Treasure Island (FL)"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Jauniaux E, Ayres-de-Campos D (2018) FIGO consensus guidelines on placenta accreta spectrum disorders: Introduction,. Int J Gynecol Obstet 140:261\u2013264. https:\/\/doi.org\/10.1002\/ijgo.12406","DOI":"10.1002\/ijgo.12406"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Obstetric Care Consensus No. 7 Summary: Placenta Accreta Spectrum. Obstet Gynecol (2018) 132:1519\u20131521. https:\/\/doi.org\/10.1097\/AOG.0000000000002984","DOI":"10.1097\/AOG.0000000000002984"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Chandraharan E, Rao S, Belli A-M, Arulkumaran S (2012) The Triple-P procedure as a conservative surgical alternative to peripartum hysterectomy for placenta percreta. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet 117:191\u2013194. https:\/\/doi.org\/10.1016\/j.ijgo.2011.12.005","DOI":"10.1016\/j.ijgo.2011.12.005"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Society of Gynecologic Oncology, American College of Obstetricians and Gynecologists and the Society for Maternal\u2013Fetal Medicine, Cahill AG, et al (2018) Placenta Accreta Spectrum. Am J Obstet Gynecol 219:B2\u2013B16. https:\/\/doi.org\/10.1016\/j.ajog.2018.09.042","DOI":"10.1016\/j.ajog.2018.09.042"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Palacios Jaraquemada JM, Pesaresi M, Nassif JC, Hermosid S (2004) Anterior placenta percreta: surgical approach, hemostasis and uterine repair. Acta Obstet Gynecol Scand 83:738\u2013744. https:\/\/doi.org\/10.1111\/j.0001-6349.2004.00517.x","DOI":"10.1080\/j.0001-6349.2004.00517.x"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Palacios-Jaraquemada JM, Basanta N, Labrousse C, Mart\u00ednez M (2021) Pregnancy outcome in women with prior placenta accreta spectrum disorders treated with conservative-reconstructive surgery: analysis of 202 cases. J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 1\u20135. https:\/\/doi.org\/10.1080\/14767058.2021.1910671","DOI":"10.1080\/14767058.2021.1910671"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Allen L, Jauniaux E, Hobson S, et al (2018) FIGO consensus guidelines on placenta accreta spectrum disorders: Nonconservative surgical management,. Int J Gynecol Obstet 140:281\u2013290. https:\/\/doi.org\/10.1002\/ijgo.12409","DOI":"10.1002\/ijgo.12409"},{"key":"ref25","unstructured":"Dai YM, Wei J, Wang ZQ, et al (2020) [Intrauterine balloon tamponade combined with temporary abdominal aortic balloon occlusion in the management of women with placenta accreta spectrum:a randomized controlled trial]. Zhonghua Fu Chan Ke Za Zhi 55:450\u2013456. https:\/\/doi.org\/10.3760\/cma.j.cn112141-20200225-00135"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Shamshirsaz AA, Fox KA, Erfani H, et al (2018) Outcomes of Planned Compared With Urgent Deliveries Using a Multidisciplinary Team Approach for Morbidly Adherent Placenta. 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