{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T08:00:49Z","timestamp":1723017649668},"reference-count":23,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>Urinary tract infections (UTIs) remain an urgent issue in clinical pediatrics. Empirical selection of antibacterial therapy becomes more complicated, and antibacterial drug indication is not always clinically substantiated. This study aimed to compare the antibacterial susceptibility pattern of the main group of urinary tract infectious agents from 2009\u20132016 with intermediate results from 2020\u20132021, during the COVID-19 pandemic, among children in the Chernivtsi region. Urine samples were collected from 3089 children (0\u201317 years old) treated at the health care institutions in the Chernivtsi region (2009\u20132016). The clinical-laboratory examination of 177 children (0\u201317 years old) was carried out from 2020 to 2021. The children received specialized medical care at the Department of Nephrology. Preliminary data of regional monitoring (2020\u20132021) are not considerably different from the previous regional susceptibility of antibiotics: to penicillin (p&lt;0.01), \u0406\u0406-\u0406\u0406\u0406 generation cephalosporin (p&lt;0.01); an increased resistance to levofloxacin (\u03c7<jats:sup>2<\/jats:sup>=4,338; p&lt;0.01), tetracycline \u2013 \u03c7<jats:sup>2<\/jats:sup>=7,277; p&lt;0.01; doxycycline \u2013 \u03c7<jats:sup>2<\/jats:sup>=5,309; p&lt;0.01) and imipenem \u2013 \u03c7<jats:sup>2<\/jats:sup>=5,594; p&lt;0.01). The data obtained did not explain an increased resistance to fluoroquinolones completely (ofloxacin, pefloxacin, ciprofloxacin), except for levofloxacin (\u03c7<jats:sup>2<\/jats:sup>=4,338; p&lt;0.01). A reliable difference of susceptibility of tetracycline group was registered (tetracycline \u2013 \u03c7<jats:sup>2<\/jats:sup>=7,277; p&lt;0.01; doxycycline \u2013 \u03c7<jats:sup>2<\/jats:sup>=5,309; p&lt;0.01). Furthermore, there was a regional increase in some UTI-pathogen strains resistant to carbapenems (imipenem \u2013 \u03c7<jats:sup>2<\/jats:sup>=5,594; p&lt;0.01). The use of antibiotics from the group of penicillins and II-III generation cephalosporins as the starting antibacterial therapy for STIs during the COVID-19 pandemic should be justified. A regional increase (2020\u20132021) of some uropathogenic strains resistant to carbapenems administered to treat severe bacterial infections requires their exclusively designated purpose in everyday pediatric practical work.<\/jats:p>","DOI":"10.25122\/jml-2021-0293","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T14:33:21Z","timestamp":1668695601000},"page":"617-619","source":"Crossref","is-referenced-by-count":1,"title":["Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic"],"prefix":"10.25122","volume":"15","author":[{"given":"Volodymyr Volodymyrovych","family":"Bezruk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Pediatrics, Neonatology and Perinatology Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Volodymyr Volodymyrovych Bezruk, Department of Pediatrics, Neonatology and Perinatology Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine. E-mail: vvladimyrbezruk@gmail.com","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Dmytrovych","family":"Shkrobanets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"2. Department of Medical and Organizational Management, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksii Serhiiovych","family":"Godovanets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Pediatrics, Neonatology and Perinatology Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr Hryhorovych","family":"Buriak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Pediatrics, Neonatology and Perinatology Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Ivanivna","family":"Pervozvanska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"3. Department of Nephrology, Pediatric Clinical Hospital, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila Mykhailivna","family":"Honcharuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"4. Department of Internal Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina Ivanivna","family":"Voytkevich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"5. Department of Foreign Languages, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena Victorivna","family":"Makarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"6. Department of Care for Patients and Higher Nursing Education, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana Ivanivna","family":"Yurkiv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"6. Department of Care for Patients and Higher Nursing Education, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Ivanovych","family":"Sheremet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"7. Surgery Department No.1, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mykhailo Mykhailovich","family":"Hresko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"7. Surgery Department No.1, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariya Ivanivna","family":"Velia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"8. Department of Pharmacy, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svyatoslava Vasylivna","family":"Yurniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"8. Department of Pharmacy, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryna Dmytrivna","family":"Hresko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"9. Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetiana Sergiivna","family":"Bulyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"9. Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larysa Vasylyvna","family":"Rynzhuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"9. Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2022,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"1. Pedroso MM, Selleck C, Enculescu C, Harmer JR, et al. Characterization of a highly efficient antibiotic-degrading metallo-\u03b2-lactamase obtained from an uncultured member of a permafrost community. 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Baba H, Kanamori H, Seike I, Niitsuma-Sugaya I, et al. Multiple Secondary Healthcare-Associated Infections Due to Carbapenem-Resistant Organisms in a Critically Ill COVID-19 Patient on Extensively Prolonged Venovenous Extracorporeal Membrane Oxygenation Support-A Case Report. Microorganisms. 2021 Dec 23;10(1):19. doi: 10.3390\/microorganisms10010019.","DOI":"10.3390\/microorganisms10010019"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-15-617.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T14:33:30Z","timestamp":1668695610000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-15-617.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["JMedLife-15-617"],"URL":"https:\/\/doi.org\/10.25122\/jml-2021-0293","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"type":"print","value":"1844-122X"},{"type":"electronic","value":"1844-3117"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}