{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:30:22Z","timestamp":1791243022895,"version":"4.1.0"},"reference-count":34,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>A double-blind clinical trial was conducted to examine the effect of concentrated growth factor (CGF), a new generation of platelet derivatives, on the healing outcome of maxillary sinus floor augmentation during maxillary sinus lift surgery. The study included 9 patients referred to the Tabriz University, Faculty of Dentistry, aged 30-80 years, with bilateral posterior partial edentulous or edentulous maxilla who underwent the procedure using a split-mouth technique. After lifting the Schneiderian membrane, bovine xenograft was randomly applied on one side (for example, left maxillary sinus) and CGF on the other side (for example, right maxillary sinus). Results from alizarin red and hematoxylin-eosin staining methods showed that the percentage of bone formed in the CGF group (112.41\u00b126.34% and 96.16\u00b124.49%, respectively) was significantly higher than in the control group (64.99\u00b124.96% and 60.16\u00b116.39%, respectively) (P&lt;0.05). In addition, after 6 months, the amount of residual graft material in the control group (xenograft) was significantly higher than in the CGF group (P&lt;0.05). These findings demonstrate that the use of CGF during open sinus lift surgery is reliable for the placement of dental implants.<\/jats:p>","DOI":"10.25122\/jml-2021-0294","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T02:11:26Z","timestamp":1683511886000},"page":"267-276","source":"Crossref","is-referenced-by-count":15,"title":["Histological examination of the effect of concentrated growth factor (CGF) on healing outcomes after maxillary sinus floor augmentation surgery"],"prefix":"10.25122","volume":"16","author":[{"given":"Mohammad","family":"Ghasemirad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Taghi","family":"Chitsazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"* Corresponding Author: Mohammad-Taghi Chitsazi, Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. E-mail: g4_4_8@hotmail.com","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Faramarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Roshangar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Anatomical Sciences, Stem Cell Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirreza","family":"Babaloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramtin","family":"Chitsazha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","published-online":{"date-parts":[[2023,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"1. Silva LD, de Lima VN. Maxillary sinus lift surgery-with or without graft material? A systematic review. International Journal of Oral and Maxillofacial Surgery. 2016;45(12);1570-1576. DOI: 10.1016\/j.ijom.2016.09.023","DOI":"10.1016\/j.ijom.2016.09.023"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"2. Danesh-Sani SA, Wallace SS. A comprehensive clinical review of maxillary sinus floor elevation: anatomy, techniques, biomaterials and complications. British Journal of Oral and Maxillofacial Surgery. 2016;54(7):724-730. DOI: 10.1016\/j.bjoms.2016.05.008","DOI":"10.1016\/j.bjoms.2016.05.008"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"3. Rosano G, Taschieri S, Gaudy JF, Weinstein T, Del Fabbro M. Maxillary sinus vascular anatomy and its relation to sinus lift surgery. Clinical Oral Implants Research. 2011;22(7):711-5. DOI: 10.1111\/j.1600-0501.2010.02045.x","DOI":"10.1111\/j.1600-0501.2010.02045.x"},{"key":"ref4","unstructured":"4. Forabosco A, Gheno E, Spinato S, Garuti G, et al. Concentrated growth factors in maxillary sinus floor augmentation: A preliminary clinical comparative evaluation. International Journal of Growth Factors and Stem Cells in Dentistry. 2018;1:2-7. DOI: 10.4103\/GFSC.GFSC_6_18"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"5. Choukroun J, Diss A, Simonpieri A, Girard MO, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2006;101(3):299-303. DOI: 10.1016\/j.tripleo.2005.07.012","DOI":"10.1016\/j.tripleo.2005.07.012"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"6. Tatullo M, Marrelli M, Cassetta M, Pacifici A, et al. Platelet Rich Fibrin (PRF) in reconstructive surgery of atrophied maxillary bones: clinical and histological evaluations. International Journal of Medical Sciences. 2012;9(10):872-80. DOI: 10.7150\/ijms.5119","DOI":"10.7150\/ijms.5119"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"7. Naofumi A, Michinori M. Sinus floor elevation with platelet-rich fibrin alone: A Clinical retrospective study of 1-7 years. Journal of Clinical and Experimental Dentistry. 2018; 10(10):984\u201391. DOI: 10.4317\/jced.55113","DOI":"10.4317\/jced.55113"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"8. Chen X, Wang J, Yu L, Zhou J, et al. Effect of Concentrated Growth Factor (CGF) on the Promotion of Osteogenesis in Bone Marrow Stromal Cells (BMSC) in vivo. Scientific Report. 2018;8(1):5876. DOI: 10.1038\/s41598-018-24364-5","DOI":"10.1038\/s41598-018-24364-5"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"9. Kim TH, Kim SH, S\u00e1ndor GK. Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbitskull defect healing. Archives of Oral Biology. 2014;59(5):550-8. DOI: 10.1016\/j.archoralbio.2014.02.004","DOI":"10.1016\/j.archoralbio.2014.02.004"},{"key":"ref10","unstructured":"10. Jaishree T, Rubine S. Innovation in regeneration \u2013 Concentrated growth factor. International Journal of Applied Dental Sciences. 2017; 3(2): 206-208"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"11. Rochira A, Siculella L, Damiano F. Concentrated Growth Factors (CGF) Induce Osteogenic Differentiation in Human Bone Marrow Stem Cells. Biology (Basel). 2020 Oct 30;9(11):370. Doi: 10.3390\/biology9110370.","DOI":"10.3390\/biology9110370"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"12. Yu X, Ren H, Shang Q , Liang D, Xiaobing J. P17. Effect of bone marrow mesenchymal stem cell combined with concentrate growth factor (CGF) on postmenopausal bone defects. The Spine Journal. 2019 Sep 1;19(9):S166. Doi:10.1016\/j.spinee.2019.05.441.","DOI":"10.1016\/j.spinee.2019.05.441"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"13. Chen Y, Cai Z. Inlay osteotome sinus floor elevation with concentrated growth factor application and simultaneous short implant placement in severely atrophic maxilla. Scientific Reports. 2016;6:27348. DOI: 10.1038\/srep27348","DOI":"10.1038\/srep27348"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"14. Lokwani BV, Gupta D, Agrawal RS, Mehta S, Nirmal NJ. The use of concentrated growth factor in dental implantology: A systematic review. J Indian Prosthodont Soc. 2020;20(1):3-10. DOI: 10.4103\/jips.jips_375_19","DOI":"10.4103\/jips.jips_375_19"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"15. Chitsazi MT, Dehghani AH, Babaloo AR. Radiographic comparison of density and height of posterior maxillary bone after open sinus lift surgery with and without PRF. Journal of advanced periodontology and implant dentistry. 2018;10(2): 43-49. DOI: 10.15171\/japid.2018.008","DOI":"10.15171\/japid.2018.008"},{"key":"ref16","unstructured":"16. Chitsazi MT, Roshangar L, Shirmohammadi A, Esmaieli F, et al. Evaluation of the Effect of Low-level Laser on Biomaterials Used in Maxillary Sinus Grafts Using Histological and Radiologic Examinations: A Randomized Controlled Clinical Trial. Journal of International Oral Health. 2016;8(7):801. DOI: 10.2047\/jioh-08-07-11"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"17. Mijiritsky E, Assaf HD, Peleg O, Shacham M, et al. Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation-A Narrative Review. Biology (Basel). 2021 Apr 10;10(4):317. Doi: 10.3390\/biology10040317","DOI":"10.3390\/biology10040317"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"18. Berberi A,Nader N. Sinus Floor Augmentation With Ambient Blood and an Absorbable Collagen Sponge: A Prospective Pilot Clinical Study. Journal of Implant Dentistry. 2017;26(5):674-681. DOI: 10.1097\/ ID.0000000000000631","DOI":"10.1097\/ID.0000000000000631"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"19. Gashtasbi F, Hasannia S, Hasannia S, Mahdi Dehghan M, et al. Comparative study of impact of animal source on physical, structural, and biological properties of bone xenograft. Xenotransplantation. 2020 Nov;27(6):e12628. doi: 10.1111\/xen.12628","DOI":"10.1111\/xen.12628"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"20. Jong Ho L, Yong-Cheol S, Oh Seong J, Seok Hee K. Reduced graphene oxide-coated hydroxyapatite composites stimulate spontaneous osteogenic differentiation of human mesenchymal stem cells. Nanoscale. 2015; 7:11642-51. DOI: 10.1039\/c5nr01580d","DOI":"10.1039\/C5NR01580D"},{"key":"ref21","unstructured":"21. Shetty M, Kalra R, Hegde C. Maxillary sinus augmentation with concentrated growth factors: radiographic evaluation. Journal of Osseointegration. 2018;10(4):109-114. DOI:10.23805 \/JO.2018.10.04.01"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"22. Sohn DS, Heo JU, Kwak DH, Kim DE, et al. Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone. Implant Dent. 2011 Oct;20(5):389-95. Doi: 10.1097\/ ID.0b013e31822f7a70","DOI":"10.1097\/ID.0b013e31822f7a70"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"23. Park IS, Sohn DS. Maxillary sinus elevation using concentrated growth factor (CGF), International Journal of Oral and Maxillofacial Surgery, 2011;40(10):P1133. DOI: 10.1016\/j.ijom.2011.07.360","DOI":"10.1016\/j.ijom.2011.07.360"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"24. Qin J, Wang L, Sun Y, Sun X, et al. Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo. Int J Mol Med. 2016 Feb;37(2):493-500. Doi: 10.3892\/ijmm.2015.2438","DOI":"10.3892\/ijmm.2015.2438"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"25. Yu M, Wang X, Liu Y, Qiao J. Cytokine release kinetics of concentrated growth factors in different scaffolds. Clin Oral Investig. 2019;23(4):1663-1671. DOI: 10.1007\/s00784-018-2582-z","DOI":"10.1007\/s00784-018-2582-z"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"26. Adal\u0131 E, Y\u00fcce MO, G\u00fcnbay T, G\u00fcnbay S. Does Concentrated Growth Factor Used With Allografts in Maxillary Sinus Lifting Have Adjunctive Benefits? J Oral Maxillofac Surg. 2021 Jan;79(1):98-108. DOI: 10.1016\/j. joms.2020.07.217","DOI":"10.1016\/j.joms.2020.07.217"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"27. Tekin U, \u00d6zt\u00fcrk D, G\u00fcneri P. Clinical and radiological comparison of the effects of concentrated growth factor on bone formation used in closed sinus lifting applications. Clinical Oral Implants Research. 2019;30(S19):527. DOI: 10.1111\/clr.482_13509","DOI":"10.1111\/clr.482_13509"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"28. Thor A, Sennerby L, Hirsch JM, Rasmusson L. Bone formation at the maxillary sinus floor following simultaneous elevation of the mucosal lining and implant installation without graft material: an evaluation of 20 patients treated with 44 Astra Tech implants. Journal of Oral and Maxillofacial Surgery. 2007;65(7):64-72. DOI: 10.1016\/j.joms.2006.10.047","DOI":"10.1016\/j.joms.2006.10.047"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"29. Riben C, Thor A. The maxillary sinus membrane elevation procedure: augmentation of bone around dental implants without grafts\u2014a review of a surgical technique. International Journal of Dentistry. 2012;20(6). DOI: 10.1155\/2012\/105483","DOI":"10.1155\/2012\/105483"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"30. Kim HR, Choi BH, Xuan F, Jeong SM. The use of autologous venous blood for maxillary sinus floor augmentation in conjunction with sinus membrane elevation: an experimental study. Clinical Oral Implants Research. 2010;21(3):346-9. DOI: 10.1111\/j.1600-0501.2009.01855.x","DOI":"10.1111\/j.1600-0501.2009.01855.x"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"31. Sul SH, Choi BH, Li J, Jeong SM, Xuan F. Effects of sinus membrane elevation on bone formation around implants placed in the maxillary sinus cavity: an experimental study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics. 2008;105(6):684-7. DOI: 10.1016\/j. tripleo.2007.09.024","DOI":"10.1016\/j.tripleo.2007.09.024"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"32. Kim BJ, Kim SK, Lee JH. Bone regeneration of demineralized dentin matrix with platelet-rich fibrin and recombinant human bone morphogenetic protein-2 on the bone defects in rabbit calvaria. Maxillofac Plast Reconstr Surg 2021;43(34). DOI: 10.1186\/s40902-021-00320-8","DOI":"10.1186\/s40902-021-00320-8"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"33. Sousa S, Igor LC, Lawrence A. Osteoconduction and Bioresorption of Bone Allograft versus Anorganic Bovine Bone Xenograft: A Histomorphometric Study in Humans. Journal of Biomimetics, Biomaterials and Tissue Engineering. 2013;18:85-95. DOI:10.4028\/www.scientific.net\/jbbte.18.85.","DOI":"10.4028\/www.scientific.net\/JBBTE.18.85"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"34. Galindo-Moreno P, Buitrago J, Padial M. Histopathological comparison of healing after maxillary sinus augmentation using xenograft mixed with autogenous bone versus allograft mixed with autogenous bone. Clinical Oral Implant Research. 2018; 29:192\u2013201. DOI: 10.1111\/clr.13098","DOI":"10.1111\/clr.13098"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/18.-jml-2021-0294.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T02:11:38Z","timestamp":1683511898000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/18.-jml-2021-0294.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["JMedLife-16-267"],"URL":"https:\/\/doi.org\/10.25122\/jml-2021-0294","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"value":"1844-122X","type":"print"},{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}