{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:18:25Z","timestamp":1775218705850,"version":"3.50.1"},"reference-count":0,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>Fungal flora is one of the causes of inflammatory, including polypous, processes in the nasal cavity. In this regard, studies aimed at reducing the effect of fungal sensitization (FS) on the course of chronic polypous rhinosinusitis (CPRS) are relevant. The objective of the study was to evaluate the effect of various treatment options on the clinical course of the disease in patients with chronic polypous rhinosinusitis against the background of sensitization to fungi. The study included 90 patients with chronic polypous rhinosinusitis in combination with FS. The patients were divided into two groups \u2013 the first clinical group (G1) and the second clinical group (G2). G1 patients received allergen-specific immunotherapy (ASIT) according to the scheme. G2 patients received basic treatment. Evaluation of the clinical efficiency of ASIT was made based on complaints, assessment of symptom severity on a visual analog scale (VAS), and rhinoendoscopic examination. The treatment outcomes were evaluated on a 4-point scale, with excellent results (4 points) \u2013 complete remission of the disease during the follow-up period (6\u201312 months); good (3 points) \u2013 exacerbation of the disease 1-2 times a year, in mild form and removed by expectant treatment; satisfactory (2 points) \u2013 the number of exacerbations did not decrease. The use of ASIT therapy is pathogenetically justified and leads to a significant improvement in the clinical condition of patients with CPRS with FS.<\/jats:p>","DOI":"10.25122\/jml-2021-0389","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T05:44:37Z","timestamp":1668836677000},"page":"359-361","source":"Crossref","is-referenced-by-count":2,"title":["Clinical efficiency of allergen-specific immunotherapy with fungal allergens in patients with chronic polypous rhinosinusitis against the background of fungal sensitization"],"prefix":"10.25122","volume":"15","author":[{"given":"Olesia","family":"Mykhailivna Herych","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Olesia Mykhailivna Herych, Department of Otorhinolaryngology Head and Neck Surgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine. E-mail: olesya-ff@ukr.net","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasyl","family":"Ivanovich Popovych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanna","family":"Vasylivna Koshel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Therapy and Family Medicine of Postgraduate Education, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Tadeivna Orishchak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ostap","family":"Romanovych Orishchak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaroslav","family":"Romanovych Maksymenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrii","family":"Volodymyrovich Bocharow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Surgery, Bukovinian State Medical University, Chernivtsi, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petro","family":"Romanovych Herych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Internal Medicine No.1, Clinical Immunology and Allergology named after Academician E.M. Neiko, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2022,3]]},"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-15-359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T05:44:38Z","timestamp":1668836678000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-15-359.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["JMedLife-15-359"],"URL":"https:\/\/doi.org\/10.25122\/jml-2021-0389","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"value":"1844-122X","type":"print"},{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}