{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:06:26Z","timestamp":1767625586097},"reference-count":37,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>Nutrient canals (NCs) are passages containing neurovascular bundles (blood vessels, lymph vessels, and nerves). Best visualized on mandibular anterior intraoral periapical radiographs (IOPAR), their presence is usually associated with underlying pathological such as diabetes mellitus (DM), hypertension (HTN), advanced periodontitis, calcium deficiency, tuberculosis, and disuse atrophy. This study aimed to (a) evaluate NC prevalence in patients with DM, HTN, and chronic periodontitis and (b) correlate the detection of NCs as an important preliminary screening tool for inherent systemic diseases like DM, HTN, and chronic periodontitis and as an investigative clue in age and gender determination. This cross-sectional study was conducted on 200 subjects. Patients with complaints of pain in the mandibular anterior teeth, deep dentinal caries, abrasion, and attrition were subjected to IOPAR of the mandibular anterior teeth region to assess NCs. An increased frequency of NCs in DM (84%), HTN (66%), and periodontitis (52%) with a significant p-value was observed. Most NCs were seen beyond the root apex (72.4%). A notable association between the duration of disease and the presence of NCs in the diabetic and hypertensive cohorts (p-value 0.047 &amp; 0.012, respectively) was observed. However, we could not establish any association between the prevalence of nutrient canals with age and gender. Our study suggested that a higher frequency of NCs on mandibular anterior IOPAR may be employed as an ancillary screening and investigative support in underlying systemic disorders.<\/jats:p>","DOI":"10.25122\/jml-2022-0009","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T14:34:49Z","timestamp":1668695689000},"page":"661-668","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of nutrient canals in mandibular anterior intra-oral periapical radiographs (IOPARS) in patients with chronic systemic diseases \u2013 a cross-sectional study"],"prefix":"10.25122","volume":"15","author":[{"given":"Shamimul","family":"Hasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Shamimul Hasan, Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India. E-mail: shasan1@jmi.ac.in","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulfat","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"2. Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shazina","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"3. Amity Institute of Public Health, Amity University, Noida, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virender","family":"Gombra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpita","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahnaz","family":"Mansoori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"1. Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10755","published-online":{"date-parts":[[2022,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"1. Mani S, Vardhan H, Ravindranath, Manohar J,et al.Prevalence of nutrient canals in diabetes mellitus and hypertension: A radiographic study. J Pharm Bioallied Sci. 2013;5(1):S21-24. doi: 10.4103\/0975-7406.113286.","DOI":"10.4103\/0975-7406.113286"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"2. Hirschfield I. A study of skull in the American museum of natural history in relation to periodontal disease. J Dent Res. 1923; 5:241-265. https:\/\/doi.org\/10.1177\/00220345230050040201","DOI":"10.1177\/00220345230050040201"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"3. Lovette DW. Nutrient canals: A roentgenographic study. J Am Dent Assoc. 1948;37:671-675. doi: 10.14219\/jada.archive.1948.0150.","DOI":"10.14219\/jada.archive.1948.0150"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"4. Britt GN. A study of human mandibular nutrient canals. Oral Surg Oral Med Oral Pathol. 1977; 44:635-645. doi: 10.1016\/0030-4220(77)90310-3.","DOI":"10.1016\/0030-4220(77)90310-3"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"5. Patni VM, Merchant GJ, Dhooria HS. Incidence of nutrient canal in hypertensive patients: A radiographic study. Oral Surg Oral Med Oral Pathol. 1985; 59:206-211. doi: 10.1016\/0030-4220(85)90020-9.","DOI":"10.1016\/0030-4220(85)90020-9"},{"key":"ref6","unstructured":"6. White S, Pharaoh M. Oral radiology: Principles and interpretations 2004;5thed. St Louis MO: Mosby."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"7. Behl AB, Bali R, Ahmed J, Singh MP,et al.Intra-oral periapical study of nutrient canals in relation to diabetes mellitus, hypertension and normal subjects. J. Stomat. Occ. Med. 2011;4:127\u2013132. https:\/\/doi.org\/10.1007\/s12548-011-0027-2","DOI":"10.1007\/s12548-011-0027-2"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"8. Carroll M, Hirschmann P. The Involvement of Nutrient Canals in Periapical Pathology. Dentomaxillofacial Radiology. 1980;9(1):18-20. doi: 10.1259\/dmfr.1980.0004.","DOI":"10.1259\/dmfr.1980.0004"},{"key":"ref9","unstructured":"9. Grondahl K, Ekestubbe A, Grondahl HG. In: Grondahl K, Ekestubbe A, Grondahl H.G eds. Postoperative radiographic examinations. Radiography in Oral Endosseous Prosthetics Goteborg: Nobel Biocare 1996; AB 111\u201326."},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"10. Gupta P, Naik SR, Tiwari A, Gupta M. Nutrient Canals of the Alveolar Process as an Anatomical Feature for Age and Gender Determination. J Indian Acad Oral Med Radiol. 2017; 29:358-361. doi: 10.4103\/jiaomr.jiaomr_85_17.","DOI":"10.4103\/jiaomr.jiaomr_85_17"},{"key":"ref11","unstructured":"11. Selarka B, Dudhia B, Chaudhary AR, Tarsariya V,et al.Evaluation of nutrient canals in periodontal disease, hypertension and diabetes mellitus: A case-control radiographic study. International Journal of Medical and Applied Sciences. 2014;3(4):260-268."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"12. Patel JR, Wuehrmann AH. A radiographic study of nutrient canals. Oral Surg. 1976;42(5):693\u2013701. doi: 10.1016\/0030-4220(76)90220-6.","DOI":"10.1016\/0030-4220(76)90220-6"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"13. Kishi K, Nagaoka T, Gotoh T, Imaik FY. Radiographic study of mandibular nutrient canals. Oral Surg Oral Med Oral Pathol. 1982;54:118\u201322. doi: 10.1016\/0030-4220(82)90426-1.","DOI":"10.1016\/0030-4220(82)90426-1"},{"key":"ref14","unstructured":"14. Bilge OM, Harorli A, Yilmaz AB. Radiographic study of mandibular nutrient canals. Ann Dent. 1992;51:17\u201321."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"15. Yilmaz AB, Akgul N, Akgul HM, Dagistanli S, Cakur B. Relationship between nutrient canals and hypertension. J Int Med Res. 2003;31:123\u2013125. doi: 10.1177\/147323000303100208.","DOI":"10.1177\/147323000303100208"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"16. Kaur S, Verma P, Saigal A. Evaluation of mandibular anterior nutrient canals in hypertensive and diabetes mellitus patients: A comparative radiographic study. Tzu Chi Medical Journal. 2019;31(2):118\u2013123. doi: 10.4103\/tcmj.tcmj_43_18.","DOI":"10.4103\/tcmj.tcmj_43_18"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"17. Jaju PP, Suvarna PV, Parikh NJ. Incidence of mandibular nutrient canals in hypertensive patients: A radiographic study. Indian J Dent Res. 2007;18:181\u2013185. doi: 10.4103\/0970-9290.35829.","DOI":"10.4103\/0970-9290.35829"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"18. Abdar-Esfahani M, Mehdizade M. Mandibular anterior nutrient canals in periapical radiography in relation to hypertension. Nephrourol Mon. 2013;6(1):e15292. doi:10.5812\/numonthly.15292.","DOI":"10.5812\/numonthly.15292"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"19. Poornima B, Angadi A, Sakri SB. A comparative study of mandibular nutrient canals in healthy and hypertensive subjects. J Sci Soc. 2014; 41:127-130. doi: 10.4103\/0974-5009.132861.","DOI":"10.4103\/0974-5009.132861"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"20. Kumar VR, Naik RM, Singh RT, Guruprasad Y. Incidence of nutrient canals in hypertensive patients: A radiographic study. J Nat Sci Biol Med. 2014;5(1):164-169. doi: 10.4103\/0976-9668.127318.","DOI":"10.4103\/0976-9668.127318"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"21. Castelino RL, Babu S, Shetty SR, Laxmana AR,et al.Can intra oral periapical radiographs be used as an adjunct diagnostic marker in detecting underlying systemic diseases? A randomised case control study. Cukurova Med J 2015;40:661-9. https:\/\/doi.org\/10.17826\/cutf.42128","DOI":"10.17826\/cutf.42128"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"22. Singh G, Rawson K, Kumar S, Srivastava A,et al.Evaluation of mandibular anterior nutrient canals in periodontal diseases: A prospective case control radiographic study. J Indian Acad Oral Med Oral Radiol 2011;23:5-8. doi: 10.5005\/jp-journals-10011-1079.","DOI":"10.5005\/jp-journals-10011-1079"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"23. Goodman-Topper ED, Chosack A. Radiographic appearance of nutrient canals in the region of the erupting permanent maxillary cuspid. Oral Surg Oral Med Oral Pathol. 1989;67(5):606-610. doi: 10.1016\/0030-4220(89)90281-8.","DOI":"10.1016\/0030-4220(89)90281-8"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"24. Reddy VG, Ali IM, Shashikanth MC. An intraoral periapical radiographic study of nutrient canals as a diagnostic aid in the systemic diseases and pathological conditions. J Indian Acad Oral Med Radiol. 2008;20(2):49\u201353. https:\/\/www.jiaomr.in\/text.asp?2008\/20\/2\/49\/44364","DOI":"10.4103\/0972-1363.44364"},{"key":"ref25","unstructured":"25. Yustiaputri F, Astuti ER, Noerjanto RP. Raiographic appearance of nutrient canals in diabetes mellitus patients. Dentomaxillofac Radiol Dent. J 2012;3:2."},{"key":"ref26","unstructured":"26. Donta CN, Pierrakou ED, Patsakas AJ. Incidence of nutrient canals in hypertensive patients with alveolar bone loss. A radiographic study. Hell Period Stomat Gnathopathoprosopike Cheir. 1989;4:149-52."},{"key":"ref27","unstructured":"27. Kaul V, Kaul R, Ahmed R, Singh S, Kapoor M. Incidence of mandibular nutrient canals in a hypertensive and diabetic population: A prospective cross-sectional radiographic study. IP International Journal of Maxillofacial Imaging 2017;13(4):120-123. doi: 10.18231\/2455-6750.2017.0028."},{"key":"ref28","unstructured":"28. Patsakas AJ, Donta CN. Incidence of nutrient canals in hypertensive patients. Hell Stomatol Chron 1990; 34:41-46."},{"key":"ref29","unstructured":"29. Pandarinath BW. A Radiographic study of mandibular nutrient canals in patients with periodontal diseases. Int Arab J Dent. 2035; 4:24-31. https:\/\/journals.usj.edu.lb\/iajd\/article\/view\/239"},{"key":"ref30","unstructured":"30. Pierrakou ED, Donta CN. The nutrient canals. Radiographic alterations of the mandibular anterior region in diabetic patients. Odontostomatol Proodos. 1990; 44:331-337."},{"key":"ref31","unstructured":"31. Isselbacher KJ. Harrison's principles of internal medicine.13thed. 1994, New York: McGraw-Hill Inc."},{"key":"ref32","unstructured":"32. Haslett C, Chilvers ER, Boon NA, College NR. Davidson's Principles and Practice of Medicine, London, UK: Churchill Livingstone Company; 2002;388\u201392."},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"33. Wang PD, Serman NJ, Kaufman E. Continuous radiographic visualization of the mandibular nutrient canals. Dentomaxillofac Radiol. 2001;30(2):131\u2013132. doi: 10.1038\/sj\/dmfr\/4600582.","DOI":"10.1038\/sj.dmfr.4600582"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"34. Ryder WB. The significance of circulatory canals in roentgenograms of alveolar process. Am J Orthod Oral Surg. 1942;28:640\u201351. https:\/\/doi.org\/10.1016\/S0096-6347(42)90029-2","DOI":"10.1016\/S0096-6347(42)90029-2"},{"key":"ref35","unstructured":"35. Stafne EC, Gibilisco JA, Turlington EG. In: Gibilisco JA, editor. Stafne's Oral radiographic diagnosis 5thed. W.B. Saunders Company; 1985;3-4."},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"36. Ennis LM. Roentgenographic variations of the maxillary sinus and the nutrient canals of the maxilla and the mandible. In: Ivy RH, Thoma KH, editors. Dental roentgenology, 2nded. Lea and Febiger; 1931;173-193.","DOI":"10.1016\/S1072-3498(37)80010-2"},{"key":"ref37","unstructured":"37. Manja CD, Boel T, Dennis, Reska AG. Prevalence of nutrient canals Anterior mandibular in hypertensive and non-hypertensive patients using periapical radiographs. NVEO-Natural Volatiles & Essent. Oils. 2021;8(4):4055-4062."}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-15-661.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T22:48:56Z","timestamp":1678661336000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/JMedLife-15-661.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["JMedLife-15-661"],"URL":"https:\/\/doi.org\/10.25122\/jml-2022-0009","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"type":"print","value":"1844-122X"},{"type":"electronic","value":"1844-3117"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}