{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:00:53Z","timestamp":1783501253456,"version":"3.55.0"},"reference-count":16,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>The Austrian gynecologist Ernst Wertheim (1864-1920) was a pioneer in the surgical treatment of cancer. The principle of Wertheim\u2019s hysterectomy was to remove the uterus and the cervix with appropriate parametrium and tissues surrounding the upper vagina and pelvic lymph nodes. However, in the early 2000s, a meta-analysis of randomized trials revealed that radiotherapy and concomitant chemotherapy without surgical removal of the uterus were more effective in the historical treatment of advanced cervical cancer. This finding challenged the use of radical abdominal hysterectomy (RAH) in such cases and demonstrated the superiority of radiotherapy and chemotherapy in terms of overall survival.<\/jats:p>","DOI":"10.25122\/jml-2022-0082","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T02:30:54Z","timestamp":1683513054000},"page":"341-343","source":"Crossref","is-referenced-by-count":5,"title":["125 years of the Wertheim operation. What next?"],"prefix":"10.25122","volume":"16","author":[{"given":"Emmanuel","family":"Drouin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Neurology Service, Lille Catholic Institute Hospital Group, Lomme cedex, France","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"* Corresponding Author: Emmanuel Drouin, Neurology Service, Lille Catholic Institute Hospital Group, Lomme cedex, France. E-mail: emmanuel.drouin@univ-catholille.fr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Classe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Ouest Cancer Institute, Saint Herblain, France","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Cancerology, Medical University, Nantes, France","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hautecoeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Neurology Service, Lille Catholic Institute Hospital Group, Lomme cedex, France","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"ref1","unstructured":"1. Temkin O. Soranus\u2019 Gynaecology. Translated. Baltimore. Johns Hopkins University Press; 1991. Softshell books editions."},{"key":"ref2","unstructured":"2. Avenzoar A. Liber Teiser, sive rectification medication et regiminus. J et G de Gregoriis. Venice."},{"key":"ref3","unstructured":"3. Giacomo Berengario da Carpi. Commentaria cum amplissimis additionibus super anatomia mundi. Per H de Benedictus. Bononiae. 1521."},{"key":"ref4","unstructured":"4. Clay C. Soranus\u2019Gynaecology. the uterus. Trans Obstet Soc London. 1863;5:58\u201374."},{"key":"ref5","unstructured":"5. Clark JG. A more radical method of performing hysterectomy for cancer of the uterus. Johns Hopkins Hospital Bulletin. 1895;6:120\u20134."},{"key":"ref6","unstructured":"6. Wertheim E. A discussion on the diagnosis and treatment of cancer of the uterus. Brit Med J. 2 1905 ; 689-704."},{"key":"ref7","unstructured":"7. Leduc S. Radioth\u00e9rapie du cancer ut\u00e9rin. Arch Electricite Med Exp Clin.1906;187:3\u20134."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"8. Drouin E, Bataille FR, Mah\u00e9 MA. Le docteur St\u00e9phane Leduc et les premi\u00e8res gu\u00e9risons de cancer par radioth\u00e9rapie \u00e0 Nantes et en France [Dr. St\u00e9phane Leduc and the first treatments of cancer by irradiation in Nantes and France]. Cancer Radiother. 2014 Nov;18(7):709-12. French. doi: 10.1016\/j.canrad.2014.04.009.","DOI":"10.1016\/j.canrad.2014.04.009"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"9. M Thiery. Ernst Wertheim (1864\u20131920) and the operation of Wertheim. Gynecol Surg (2008) 5:333\u2013334. https:\/\/doi.org\/10.1007\/s10397-008-0435-5","DOI":"10.1007\/s10397-008-0435-5"},{"key":"ref10","unstructured":"10. Marin F, Plesca M, Bordea CI, Moga MA, Blidaru A. Types of radical hysterectomies : From Thoma Ionescu and Wertheim to present day. 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Les Aphorismes d'Hippocrate avec le commentaire de Galien. 1615."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"15. Cibula D, P\u00f6tter R, Planchamp F, Avall-Lundqvist E, et al. The European Society of Gynaecological Oncology\/European Society for Radiotherapy and Oncology\/European Society of Pathology guidelines for the management of patients with cervical cancer. Radiother Oncol. 2018 Jun;127(3):404-416. doi: 10.1016\/j.radonc.2018.03.003.","DOI":"10.1016\/j.radonc.2018.03.003"},{"key":"ref16","unstructured":"16. Leduc S. Les rayons de R\u00f6ntgen. Conf\u00e9rence faite le 5 mars 1896 \u00e0 l\u2019\u00e9cole des sciences et le 7 mars 1896 \u00e0 l\u2019\u00e9cole de m\u00e9decine. Gazette Med Nantes. 1896:1\u201316. [Imprimerie centrale, imprimerie de la Gazette m\u00e9dicale."}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/5.-jml-2022-0082.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T02:31:05Z","timestamp":1683513065000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/5.-jml-2022-0082.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["JMedLife-16-341"],"URL":"https:\/\/doi.org\/10.25122\/jml-2022-0082","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"value":"1844-122X","type":"print"},{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}