{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:00:38Z","timestamp":1788116438695,"version":"build-2803163510"},"reference-count":36,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"abstract":"<jats:p>The prevalence of juvenile obesity is increasing, reaching epidemic proportions, presenting a link not only to NAFLD (non-alcoholic fatty liver disease) but to abnormal lipid profiles and liver enzyme abnormalities. Liver ultrasonography is a sensitive and specific tool for the recognition of NAFLD. This study aims to assess the association between NAFLD and juvenile obesity and to determine the other related changes in a set of indicators, including lipid profile abnormalities and serum transaminases. The sample included 470 obese and 210 non-obese individuals aged 6\u201316. Anthropometric measures were assessed, with the serum lipid profile and liver transaminases, and abdominal ultrasonography was used to detect NAFLD. Fatty liver was found in 38% of the obese subjects and none of the non-obese subjects. Within obese subjects, mean body mass index (BMI) and waist circumference increased significantly in patients with NAFLD compared to those without fatty liver. Moreover, LDL (low-density lipoprotein), CHOL (cholesterol), and serum liver enzymes were significantly higher in the presence of NAFLD. In conclusion, NAFLD commonly associates with juvenile obesity, relating to obesity and the abnormal lipid profile (including elevated CHOL and LDL) among obese people, reflecting elevated liver transaminases, which increase the risk of cirrhosis.<\/jats:p>","DOI":"10.25122\/jml-2022-0091","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T01:56:18Z","timestamp":1683510978000},"page":"42-47","source":"Crossref","is-referenced-by-count":27,"title":["Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes"],"prefix":"10.25122","volume":"16","author":[{"given":"Raghid Reyadh","family":"Altalebi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Family Physician (CCFP), Madigan Medical Centre, Calgary, Alberta, Canada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany Akeel","family":"Al-hussaniy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dr. Hany Akeel Institute, Iraqi Medical Research Center, Baghdad, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"* Corresponding Author: Hany Akeel Al-hussaniy, Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq. E-mail: hany_akeel2000@yahoo.com","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa Salam","family":"Al-tameemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dr. Hany Akeel Institute, Iraqi Medical Research Center, Baghdad, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdul-Hassan","family":"AL-Zobaidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pharmacology, College of Medicine, Baghdad University, Baghdad, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Hikmat","family":"Albu-Rghaif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pharmacy, Ashur University College, Baghdad, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder Mutter","family":"Alkuraishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Clinical Pharmacology, College of Medicine, Almustansria University, Baghdad, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gomaa Mostafa","family":"Hedeab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pharmacology Department & Health Research Unit, Medical College, Jouf University, Jouf, Saudi Arabia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pharmacology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizul","family":"Azam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Uniazah, Saudi Arabia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mahmoud","family":"Al-Samydai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena Akeel","family":"Naji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dr. Hany Akeel Institute, Iraqi Medical Research Center, Baghdad, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","published-online":{"date-parts":[[2023,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"1. Jebeile H, Kelly AS, O'malley G, Baur LA. Obesity in children and adolescents: epidemiology, causes, assessment, and management. The Lancet Diabetes & Endocrinology. 2022 May;10(5):351-365. doi: https:\/\/doi. org\/10.1016\/S2213-8587(22)00047-X","DOI":"10.1016\/S2213-8587(22)00047-X"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"2. Schroeder K, Schuler BR, Kobulsky JM, Sarwer DB. The association between adverse childhood experiences and childhood obesity: A systematic review. Obes Rev. 2021; 22(7):e13204. http:\/\/dx.doi.org\/10.1111\/obr.13204","DOI":"10.1111\/obr.13204"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"3. Byrne CD, Targher G. Non-alcoholic fatty liver disease-related risk of cardiovascular disease and other cardiac complications. Diabetes, Obesity and Metabolism. 2022; 24:28-43. doi: 10.1111\/dom.14484","DOI":"10.1111\/dom.14484"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"4. Mantovani A, Dalbeni A, Beatrice G, Cappelli D, Gomez-Peralta F. Non-Alcoholic Fatty Liver Disease and Risk of Macro- and Microvascular Complications in Patients with Type 2 Diabetes. Journal of Clinical Medicine. 2022;11(4):968. https:\/\/doi.org\/10.3390\/jcm11040968","DOI":"10.3390\/jcm11040968"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"5. Holanda NCP, Oliveira ARL, Carvalho NNC, Souza BL. Non-alcoholic fatty liver disease. In: Endocrinology and Diabetes. Cham: Springer International Publishing. 2022; 443\u201350. doi: https:\/\/doi.org\/10.1186\/s12902-022-00980-1","DOI":"10.1007\/978-3-030-90684-9_42"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"6. Abdulameer AA, Mohammed ZN, Tawfeeq KT. Endoscopic characteristics and management of Subepithelial Lesions in Video-Gastascopie. Med Pharm J. 2022; 1(1):4\u201313. doi: http:\/\/dx.doi.org\/10.55940\/medphar20222","DOI":"10.55940\/medphar20222"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"7. Godinez-Leiva E, Bril F. Nonalcoholic fatty liver disease (NAFLD) for primary care providers: beyond the liver. Current Hypertension Reviews. 2021;17(2):94-111. doi:10.2174\/1573402116999201209203534","DOI":"10.2174\/1573402116999201209203534"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"8. Al-hassany HA, Albu-rghaif AH A, Naji M. Tumor diagnosis by genetic markers protein P-53, p16, C-MYC, N-MYC, protein K-Ras, and gene her- 2 Neu is this possible? Pakistan Journal of Medical and Health Sciences. 2021;15(8):2350\u20134. doi: https:\/\/doi.org\/10.53350\/pjmhs211582350","DOI":"10.53350\/pjmhs211582350"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"9. Ali A, Amin MJ, Ahmed MU, Taj A,\n                      et al.\n                      Frequency of non-alcoholic fatty liver disease (NAFLD) and its associated risk factors among Type-2 diabetics. Pakistan Journal of Medical Sciences. 2022; 38(1):28. doi: https:\/\/doi. org\/10.12669\/pjms.38.1.4968","DOI":"10.12669\/pjms.38.1.4968"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"10. Serdarova M, Dimova R, Chakarova N, Grozeva G,\n                      et al.\n                      Metabolic determinants of NAFLD in adults with type 1 diabetes. Diabetes Research and Clinical Practice. 2022; 3:109819. doi: 10.1016\/j.diabres.2022.109819","DOI":"10.1016\/j.diabres.2022.109819"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"11. Pugliese N, Plaz Torres MC, Petta S, Valenti L,\n                      et al.\n                      Is there an 'ideal'diet for patients with NAFLD?. European Journal of Clinical Investigation. 2022;52(3):e13659. doi: 10.1111\/eci.13659","DOI":"10.1111\/eci.13659"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"12. Al-hussaniy Hany, Altalebi RR, Tylor FM, Alwash AH,\n                      et al.\n                      Leptin Hormone: In Brief. Medical and Pharmaceutical Journal. 2022;1(1):1\u20133. doi: http:\/\/dx.doi.org\/10.55940\/medphar20221","DOI":"10.55940\/medphar20221"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"13. Dichtel LE, Cordoba-Chacon J, Kineman RD. Growth hormone and insulinlike growth factor I regulation of non-alcoholic fatty liver disease. J Clin Endocrinol Metab. 2022;16;107(7):1812-1824. doi: 10.1210\/clinem\/dgac088","DOI":"10.1210\/clinem\/dgac088"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"14. Li J, Huang L, Xiong W, Qian Y, Song M. Aerobic exercise improves nonalcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway. Biochem Biophys Res Commun. 2022; 603:35\u201340. http:\/\/dx.doi.org\/10.1016\/j.bbrc.2022.03.008","DOI":"10.1016\/j.bbrc.2022.03.008"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"15. Kim EJ, Kim HJ. Non-alcoholic fatty liver disease in obese and non-obese pediatric patients. Korean J Pediatr. 2019; 62(1):30\u20135. doi: 10.3345\/ kjp.2018.06786","DOI":"10.3345\/kjp.2018.06786"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"16. Delvin E, Patey N, Dubois J, Henderson M, L\u00e9vy \u00c9. Pediatric non-alcoholic fatty liver disease. J Med Biochem. 2015; 34(1):3\u201312. http:\/\/dx.doi. org\/10.2478\/jomb-2014-0059","DOI":"10.2478\/jomb-2014-0059"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"17. Al-Ghamdi S, Shubair MM, Aldiab A, Al-Zahrani JM,\n                      et al.\n                      Prevalence of overweight and obesity based on the body mass index; a cross-sectional study in Alkharj, Saudi Arabia. Lipids Health Dis. 2018; 17(1). doi: 10.1186\/ s12944-018-0778-5","DOI":"10.1186\/s12944-018-0778-5"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"18. Al-Hussaniy HA. The Effect of MicroRNA-409-3p for Treatment and Response to Tumor Proliferation of Lung Cancer Cell Lines (\n                      In vitro)\n                      . Asian Pacific Journal of Cancer Prevention. 2022; 23(9):3151-6. DOI:10.31557\/ APJCP.2022.23.9.3151","DOI":"10.31557\/APJCP.2022.23.9.3151"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"19. Al-Hussaniy HA, Alburghaif AH, Naji MA. Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions. Journal of Medicine and Life. 2021; 14(5):600-605. doi: 10.25122\/ jml-2021-0153","DOI":"10.25122\/jml-2021-0153"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"20. Sebo P, Beer-Borst S, Haller DM, Bovier PA. Reliability of doctors' anthropometric measurements to detect obesity. Preventive Medicine. 2008;47(4):389-93. doi: 10.1016\/j.ypmed.2008.06.012","DOI":"10.1016\/j.ypmed.2008.06.012"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"21. Yakubu IM, Kaoje YS, Jabbe T, Abubakar AA. Best anthropometric predictors of fasting blood sugar, prediabetes, and diabetes. Diabetes. 2020; 6:1-7. doi: 10.15761\/DU.1000149","DOI":"10.15761\/DU.1000149"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"22. Li W, Liu Q , Deng X, Chen Y,\n                      et al.\n                      Association between obesity and puberty timing: A systematic review and meta-analysis. Int J Environ Res Public Health. 2017;14(10):1266. http:\/\/dx.doi.org\/10.3390\/ijerph14101266","DOI":"10.3390\/ijerph14101266"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"23. Mascar\u00f3 CM, Bouzas C, Tur JA. Association between Nonalcoholic Fatty Liver Disease and Mediterranean Lifestyle: A Systematic Review. Nutrients. 2021;14(1):49. doi: 10.3390\/nu14010049","DOI":"10.3390\/nu14010049"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"24. Kim YJ, Yoon DS, Jung UJ. Efficacy of nobiletin in improving hypercholesterolemia and non-alcoholic fatty liver disease in high-cholesterol diet-fed mice. Nutrition Research and Practice. 2021;15(4):431-43. doi: 10.4162\/nrp.2021.15.4.431","DOI":"10.4162\/nrp.2021.15.4.431"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"25. Aboubakr A, Stroud A, Kumar S, Newberry C. Dietary approaches for management of non-alcoholic fatty liver disease: A clinician's guide. Current gastroenterology reports. 2021; 23(12):1-8. DOI: 10.1007\/s11894-021-00827-0","DOI":"10.1007\/s11894-021-00827-0"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"26. Zarghamravanbakhsh P, Frenkel M, Poretsky L. Metabolic causes and consequences of non-alcoholic fatty liver disease (NAFLD). Metabolism Open. 2021;12:100149. doi: 10.1016\/j.metop.2021.100149","DOI":"10.1016\/j.metop.2021.100149"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"27. Piazzolla VA, Mangia A. Noninvasive diagnosis of NAFLD and NASH. Cells. 2020; 9(4):1005. doi: http:\/\/dx.doi.org\/10.3390\/cells9041005","DOI":"10.3390\/cells9041005"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"28. Huivaniuk O, Stupnytska H, Fediv O, Bocharov A. The effectiveness of short-term pulmonary rehabilitation program in patients with comorbid asthma, chronic obstructive pulmonary disease and obesity. J Med Life. 2022;15(2):196\u2013201. doi: http:\/\/dx.doi.org\/10.25122\/jml-2021-0050","DOI":"10.25122\/jml-2021-0050"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"29. Al-hussaniy H, AL-Biati HA. The role Of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin\/Ghrelin ratio in Obesogenesis. Medical and Pharmaceutical Journal. 2022;1(2):12-23. doi: 10.55940\/medphar20229","DOI":"10.55940\/medphar20227"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"30. Al-hussaniy HA, Altalebi RR, Alburagheef A, Abdul-Amir AG. The Use of PCR for Respiratory Virus Detection on the Diagnosis and Treatment Decision of Respiratory Tract Infections in Iraq. J Pure Appl Microbiol. 2022; 16(1):201-6. doi: 10.22207\/JPAM.16.1.10","DOI":"10.22207\/JPAM.16.1.10"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"31. Lemoine M, Assoumou L, De Wit S, Girard PM,\n                      et al.\n                      Diagnostic accuracy of non-invasive markers of steatosis, NASH, and liver fibrosis in HIV-monoinfected individuals at risk of non-alcoholic fatty liver disease (NAFLD): results from the ECHAM study. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2019; 80(4):e86-94. doi:10.1097\/qai.0000000000001936","DOI":"10.1097\/QAI.0000000000001936"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"32. Gerges SH, Wahdan SA, Elsherbiny DA, El-Demerdash E. Non-alcoholic fatty liver disease: An overview of risk factors, pathophysiological mechanisms, diagnostic procedures, and therapeutic interventions. Life Sciences. 2021; 271:119220. doi: 10.1016\/j.lfs.2021.119220","DOI":"10.1016\/j.lfs.2021.119220"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"33. Fraile JM, Palliyil S, Barelle C, Porter AJ, Kovaleva M. Non-alcoholic steatohepatitis (NASH)\u2013A review of a crowded clinical landscape, driven by a complex disease. Drug Design, Development and Therapy. 2021; 15:3997. doi: 10.2147\/dddt.s315724","DOI":"10.2147\/DDDT.S315724"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"34. Naji MA, Alburghaif AH, Saleh NK, Al-hussaniy HA. Patient expectations regarding consultation with a family doctor: a cross-sectional study. Medical and Pharmaceutical Journal. 2022; 1(1):35-40. doi: 10.55940\/medphar20225","DOI":"10.55940\/medphar20225"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"35. Al-Juhaishi AM, Aziz ND. Safety and Efficacy of antiviral drugs against covid-19 infection: an updated systemic review. Medical and Pharmaceutical Journal. 2022; 1(2):45-55. doi: 10.55940\/medphar20226","DOI":"10.55940\/medphar20226"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"36. Cuzmar V, Alberti G, Uauy R, Pereira A,\n                      et al.\n                      Early obesity: risk factor for fatty liver disease. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70(1):93-8. doi: 10.1097\/MPG.0000000000002523","DOI":"10.1097\/MPG.0000000000002523"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/9.-jml-2022-0091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T01:56:30Z","timestamp":1683510990000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/wp-content\/uploads\/9.-jml-2022-0091.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["JMedLife-16-042"],"URL":"https:\/\/doi.org\/10.25122\/jml-2022-0091","relation":{},"ISSN":["1844-122X","1844-3117"],"issn-type":[{"value":"1844-122X","type":"print"},{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}