{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:55:50Z","timestamp":1787025350498,"version":"build-2736575974"},"reference-count":23,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"DOI":"10.25122\/jml-2023-0120","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T23:23:56Z","timestamp":1715383436000},"page":"1428-1432","source":"Crossref","is-referenced-by-count":4,"title":["Potential nephroprotective effects of angiotensin II type 2 receptor agonist Compound 21 in renal ischemia-reperfusion injury"],"prefix":"10.25122","volume":"16","author":[{"given":"Najah Rayish","family":"Hadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pharmacology & Therapeutics, Faculty of Medicine, University of Kufa, Kufa, Iraq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lafta Fayez","family":"Kadhim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Ministry of Health, Al-Najaf Health Directorate, Al-Najaf, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarmad Nory","family":"Gany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Faculty of Medicine, University of Kufa, Al-Najaf, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heider","family":"Qassam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pharmacology & Therapeutics, Faculty of Medicine, University of Kufa, Kufa, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Kadhim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"College of Pharmacy, Al-Kafeel University, Al-Najaf, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","published-online":{"date-parts":[[2023,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6618061","DOI":"10.1155\/2021\/6618061","article-title":"Mas receptor blockade promotes renal vascular response to Ang II after partial kidney ischemia\/reperfusion in a two-kidney-one-clip hypertensive rats model","volume":"2021","author":"Karimi F Nematbakhsh M","year":"2021","unstructured":"1. Karimi F Nematbakhsh M Mas receptor blockade promotes renal vascular response to Ang II after partial kidney ischemia\/reperfusion in a two-kidney-one-clip hypertensive rats model Int J Nephrol 2021 2021 6618061 10.1155\/2021\/6618061","journal-title":"Int J Nephrol"},{"issue":"2","key":"ref2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.kint.2019.02.009","article-title":"Regulated necrosis in kidney ischemia-reperfusion injury","volume":"96","author":"Pefanis A Ierino FL Murphy JM Cowan PJ","year":"2019","unstructured":"2. Pefanis A Ierino FL Murphy JM Cowan PJ Regulated necrosis in kidney ischemia-reperfusion injury Kidney Int 2019962 291301 10.1016\/j.kint.2019.02.009","journal-title":"Kidney Int"},{"issue":"2","key":"ref3","first-page":"85","article-title":"Acute kidney injury: definition, pathophysiology, and clinical phenotypes","volume":"37","author":"Makris K Spanou L","year":"2016","unstructured":"3. Makris K Spanou L Acute kidney injury: definition, pathophysiology, and clinical phenotypes Clin Biochem Rev 2016372 8598","journal-title":"Clin Biochem Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/S1166-7087(14)70057-0","article-title":"Ischemia-reperfusion: From cell biology to acute kidney injury","volume":"24","author":"Chatauret N Badet L Barrou B Hauet T","year":"2014","unstructured":"4. Chatauret N Badet L Barrou B Hauet T Ischemia-reperfusion: From cell biology to acute kidney injury Prog Urol 2014 24 Suppl 1 S412 10.1016\/S1166-7087(14)70057-0","journal-title":"Prog Urol"},{"issue":"2","key":"ref5","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ijcard.2011.05.013","article-title":"PI3K\/Akt signaling pathway involved in Cardioprotection of preconditioning with high mobility group box 1 protein during myocardial ischemia and reperfusion","volume":"150","author":"Hu X Xu C Zhou X Cui B","year":"2011","unstructured":"5. Hu X Xu C Zhou X Cui B  PI3K\/Akt signaling pathway involved in Cardioprotection of preconditioning with high mobility group box 1 protein during myocardial ischemia and reperfusion Int J Cardiol 2011 1502 2223 10.1016\/j.ijcard.2011.05.013","journal-title":"Int J Cardiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1186\/s12967-015-0699-2","article-title":"Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K\/Akt\/FoxO3a pathway","volume":"13","author":"Yang C Cao Y Zhang Y Li L","year":"2015","unstructured":"6. Yang C Cao Y Zhang Y Li L  Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K\/Akt\/FoxO3a pathway J Transl Med 201513355 10.1186\/s12967-015-0699-2","journal-title":"J Transl Med"},{"issue":"24","key":"ref7","doi-asserted-by":"publisher","first-page":"5995","DOI":"10.1021\/jm049715t","article-title":"Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist","volume":"47","author":"Wan Y Wallinder C Plouffe B Beaudry H","year":"2004","unstructured":"7. Wan Y Wallinder C Plouffe B Beaudry H  Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist J Med Chem 2004472459956008 10.1021\/jm049715t","journal-title":"J Med Chem"},{"issue":"6","key":"ref8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1517\/13543784.2012.681046","article-title":"Angiotensin II type 2 receptor agonists--where should they be applied?","volume":"21","author":"Steckelings UM Unger T","year":"2012","unstructured":"8. Steckelings UM Unger T Angiotensin II type 2 receptor agonists--where should they be applied? Expert Opin Investig Drugs 20122167636 10.1517\/13543784.2012.681046","journal-title":"Expert Opin Investig Drugs"},{"issue":"4","key":"ref9","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s12291-019-00848-7","article-title":"The Nephroprotective Effect of Lycopene on Renal Ischemic Reperfusion Injury: A Mouse Model","volume":"35","author":"Hussien YA Abdalkadim H Mahbuba W Hadi NR","year":"2020","unstructured":"9. Hussien YA Abdalkadim H Mahbuba W Hadi NR  The Nephroprotective Effect of Lycopene on Renal Ischemic Reperfusion Injury: A Mouse Model Indian J Clin Biochem 2020 354 474481 10.1007\/s12291-019-00848-7","journal-title":"Indian J Clin Biochem"},{"issue":"8","key":"ref10","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s00109-016-1406-3","article-title":"Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice","volume":"94","author":"Schwengel K Namsolleck P Lucht K Clausen BH","year":"2016","unstructured":"10. Schwengel K Namsolleck P Lucht K Clausen BH  Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice J Mol Med (Berl) 2016 948 95766 10.1007\/s00109-016-1406-3","journal-title":"J Mol Med (Berl)"},{"issue":"5","key":"ref11","doi-asserted-by":"publisher","first-page":"F814","DOI":"10.1152\/ajprenal.00507.2020","article-title":"Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia","volume":"320","author":"Ali R Patel S Hussain T","year":"2021","unstructured":"11. Ali R Patel S Hussain T Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia Am J Physiol Renal Physiol 20213205F814F825 10.1152\/ajprenal.00507.2020","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"ref12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.5530\/srp.2019.1.34","article-title":"Nephroprotective effects of quercetin in renal ischemia reperfusion injury in mice","volume":"10","author":"Al-Jabbar WA Hadi NR Ghafil FAA Abdulkadhim H","year":"2019","unstructured":"12. Al-Jabbar WA Hadi NR Ghafil FAA Abdulkadhim H  Nephroprotective effects of quercetin in renal ischemia reperfusion injury in mice Syst Rev Pharm 2019101184193 10.5530\/srp.2019.1.34","journal-title":"Syst Rev Pharm"},{"issue":"1-2","key":"ref13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2119\/molmed.2010.00111","article-title":"Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition","volume":"17","author":"Liu CX Hu Q Wang Y Zhang W","year":"2011","unstructured":"13. Liu CX Hu Q Wang Y Zhang W  Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition Mol Med 2011171-25969 10.2119\/molmed.2010.00111","journal-title":"Mol Med"},{"issue":"12","key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X20977647","article-title":"Tubeimoside-1 Protects Against Renal Ischemia Reperfusion Injury In Vivo and In Vitro","volume":"15","author":"Yuan X Wang J Zhang Y","year":"2020","unstructured":"14. Yuan X Wang J Zhang Y Tubeimoside-1 Protects Against Renal Ischemia Reperfusion Injury\n                      In Vivo and In Vitro\n                      Nat Prod Commun 20201512 10.1177\/1934578X20977647","journal-title":"Nat Prod Commun"},{"issue":"3","key":"ref15","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1124\/jpet.104.078659","article-title":"Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia\/reperfusion","volume":"312","author":"Patel NS Chatterjee PK Di Paola R Mazzon E","year":"2005","unstructured":"15. Patel NS Chatterjee PK Di Paola R Mazzon E  Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia\/reperfusion J Pharmacol Exp Ther 2005312311708 10.1124\/jpet.104.078659","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"ref16","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1111\/jcmm.12120","article-title":"Acute treatment with relaxin protects the kidney against ischaemia\/reperfusion injury","volume":"17","author":"Collino M Rogazzo M Pini A Benetti E","year":"2013","unstructured":"16. Collino M Rogazzo M Pini A Benetti E  Acute treatment with relaxin protects the kidney against ischaemia\/reperfusion injury J Cell Mol Med 2013171114941505 10.1111\/jcmm.12120","journal-title":"J Cell Mol Med"},{"issue":"5","key":"ref17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1161\/HYPERTENSIONAHA.115.06881","article-title":"Angiotensin II Type 2\u2013Receptor Agonist C21 Reduces Proteinuria and Oxidative Stress in Kidney of High-Salt\u2013Fed Obese Zucker Rats","volume":"67","author":"Patel SN Ali Q Hussain T","year":"2016","unstructured":"17. Patel SN Ali Q Hussain T Angiotensin II Type 2\u2013Receptor Agonist C21 Reduces Proteinuria and Oxidative Stress in Kidney of High-Salt\u2013Fed Obese Zucker Rats Hypertension 2016 675 906915 10.1161\/HYPERTENSIONAHA.115.06881","journal-title":"Hypertension"},{"issue":"2","key":"ref18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11255-012-0297-7","article-title":"Clamping renal artery alone produces less ischemic damage compared to clamping renal artery and vein together in two animal models: near-infrared tissue oximetry and quantitation of 8-isoprostane levels","volume":"45","author":"Colli JL Wang Z Johnsen N Grossman L Lee BR","year":"2013","unstructured":"18. Colli JL Wang Z Johnsen N Grossman L Lee BR Clamping renal artery alone produces less ischemic damage compared to clamping renal artery and vein together in two animal models: near-infrared tissue oximetry and quantitation of 8-isoprostane levels Int Urol Nephrol 2013 452 4218 10.1007\/s11255-012-0297-7","journal-title":"Int Urol Nephrol"},{"key":"ref19","article-title":"Basic and advanced laboratory techniques in histopathology and cytology","author":"Dey P","year":"2018","unstructured":"19. Dey P Basic and advanced laboratory techniques in histopathology and cytology Springer 2018","journal-title":"Springer"},{"issue":"6","key":"ref20","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.3892\/mmr.2014.2089","article-title":"Effect of gender differences on the regulation of renal ischemia-reperfusion-induced inflammation in mice","volume":"9","author":"Kang KP Lee JE Lee AS Jung YJ","year":"2014","unstructured":"20. Kang KP Lee JE Lee AS Jung YJ  Effect of gender differences on the regulation of renal ischemia-reperfusion-induced inflammation in mice Mol Med Rep 20149620618 10.3892\/mmr.2014.2089","journal-title":"Mol Med Rep"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"114804","DOI":"10.1016\/j.bcp.2021.114804","article-title":"Angiotensin II type 2 receptor agonist, compound 21, prevents tubular epithelial cell damage caused by renal ischemia","volume":"194","author":"Fussi MF Hidalgo FB Gabriel MM Susana BP","year":"2021","unstructured":"21. Fussi MF Hidalgo FB Gabriel MM Susana BP  Angiotensin II type 2 receptor agonist, compound 21, prevents tubular epithelial cell damage caused by renal ischemia Biochem Pharmacol 2021194 114804 10.1016\/j.bcp.2021.114804","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"ref22","doi-asserted-by":"publisher","first-page":"e5954","DOI":"10.1590\/1414-431X20175954","article-title":"Attenuation of renal ischemic reperfusion injury by salvianolic acid B via suppressing oxidative stress and inflammation through PI3K\/Akt signaling pathway","volume":"50","author":"Ma ZG Xia HQ Cui SL Yu J","year":"2017","unstructured":"22. Ma ZG Xia HQ Cui SL Yu J Attenuation of renal ischemic reperfusion injury by salvianolic acid B via suppressing oxidative stress and inflammation through PI3K\/Akt signaling pathway Braz J Med Biol Res 2017 506 e5954 10.1590\/1414-431X20175954","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"ref23","doi-asserted-by":"publisher","first-page":"e61982","DOI":"10.1371\/journal.pone.0061982","article-title":"Emerging role of angiotensin type 2 receptor (AT2R)\/Akt\/NO pathway in vascular smooth muscle cell in the hyperthyroidism","volume":"8","author":"Carrillo-Sep\u00falveda MA Ceravolo GS Furstenau CR Monteiro PdS","year":"2013","unstructured":"23. Carrillo-Sep\u00falveda MA Ceravolo GS Furstenau CR Monteiro PdS  Emerging role of angiotensin type 2 receptor (AT2R)\/Akt\/NO pathway in vascular smooth muscle cell in the hyperthyroidism PLoS One 2013 84 e61982 10.1371\/journal.pone.0061982","journal-title":"PLoS One"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/all-issues\/2023\/issue-9-2023\/original-article-issue-9-2023\/potential-nephroprotective-effects-of-angiotensin-ii-type-2-receptor-agonist-compound-21-in-renal-ischemia-reperfusion-injury\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T23:26:33Z","timestamp":1715383593000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/all-issues\/2023\/issue-9-2023\/original-article-issue-9-2023\/potential-nephroprotective-effects-of-angiotensin-ii-type-2-receptor-agonist-compound-21-in-renal-ischemia-reperfusion-injury\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["JMedLife-16-1428"],"URL":"https:\/\/doi.org\/10.25122\/jml-2023-0120","relation":{},"ISSN":["1844-3117"],"issn-type":[{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}