{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:53:52Z","timestamp":1794315232898,"version":"4.9.0"},"reference-count":146,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.25122\/jml-2024-0316","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T22:45:03Z","timestamp":1737672303000},"page":"978-993","source":"Crossref","is-referenced-by-count":17,"title":["Optical tweezers in biomedical research \u2013 progress and techniques"],"prefix":"10.25122","volume":"17","author":[{"given":"Tudor","family":"Savopol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Biophysics and Cellular Biotechnology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharm Singh","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Biophysics and Cellular Biotechnology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","reference":[{"issue":"6","key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/NANO13060963","article-title":"Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review","volume":"13","author":"Magazz\u00f9 A, Marcuello C","year":"2023","unstructured":"1. Magazz\u00f9 A, Marcuello C, Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review, Nanomaterials, 2023;13(6):","journal-title":"Nanomaterials"},{"issue":"4","key":"ref2","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1103\/PhysRevLett.24.156","article-title":"Acceleration and Trapping of Particles by Radiation Pressure","volume":"24","author":"Ashkin A","year":"1970","unstructured":"2. Ashkin A, Acceleration and Trapping of Particles by Radiation Pressure, Phys Rev Lett, 1970;24(4):156","journal-title":"Phys Rev Lett"},{"issue":"5","key":"ref3","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1364\/OL.11.000288","article-title":"Observation of a single-beam gradient force optical trap for dielectric particles","volume":"11","author":"Ashkin A, Dziedzic JM, Bjorkholm JE, Chu S","year":"1986","unstructured":"3. Ashkin A, Dziedzic JM, Bjorkholm JE, Chu S, Observation of a single-beam gradient force optical trap for dielectric particles, Opt Lett, 1986;11(5):288-290","journal-title":"Opt Lett"},{"issue":"6299","key":"ref4","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/348346a0","article-title":"Force generation of organelle transport measured in vivo by an infrared laser trap","volume":"348","author":"Ashkin A, Sch\u00fctze K, Dziedzic JM, Euteneuer U, Schliwa M","year":"1990","unstructured":"4. Ashkin A, Sch\u00fctze K, Dziedzic JM, Euteneuer U, Schliwa M, Force generation of organelle transport measured in vivo by an infrared laser trap, Nature, 1990;348(6299):346-348","journal-title":"Nature"},{"issue":"19","key":"ref5","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1364\/ol.18.001678","article-title":"Scanning-force microscope based on an optical trap","volume":"18","author":"Ghislain LP, Webb WW","year":"1993","unstructured":"5. Ghislain LP, Webb WW, Scanning-force microscope based on an optical trap, Opt Lett, 1993;18(19):1678-80","journal-title":"Opt Lett"},{"issue":"6299","key":"ref6","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/348348a0","article-title":"Bead movement by single kinesin molecules studied with optical tweezers","volume":"348","author":"Block SM, Goldstein LS, Schnapp BJ","year":"1990","unstructured":"6. Block SM, Goldstein LS, Schnapp BJ, Bead movement by single kinesin molecules studied with optical tweezers, Nature, 1990;348(6299):348-52","journal-title":"Nature"},{"issue":"6467","key":"ref7","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/368113a0","article-title":"Single myosin molecule mechanics: piconewton forces and nanometre steps","volume":"368","author":"Finer JT, Simmons RM, Spudich JA","year":"1994","unstructured":"7. Finer JT, Simmons RM, Spudich JA, Single myosin molecule mechanics: piconewton forces and nanometre steps, Nature, 1994;368(6467):113-119","journal-title":"Nature"},{"issue":"24","key":"ref8","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1098\/RSIF.2008.0052","article-title":"Optical tweezers for single cells","volume":"5","author":"Zhang H, Liu KK","year":"2008","unstructured":"8. Zhang H, Liu KK, Optical tweezers for single cells, J R Soc Interface, 2008;5(24):671-690","journal-title":"J R Soc Interface"},{"issue":"6150","key":"ref9","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/330769a0","article-title":"Optical trapping and manipulation of single cells using infrared laser beams","volume":"330","author":"Ashkin A, Dziedzic JM, Yamane T","year":"1987","unstructured":"9. Ashkin A, Dziedzic JM, Yamane T, Optical trapping and manipulation of single cells using infrared laser beams, Nature, 1987;330(6150):769-771","journal-title":"Nature"},{"issue":"6950","key":"ref10","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/NATURE01935","article-title":"A revolution in optical manipulation","volume":"424","author":"Grier DG","year":"2003","unstructured":"10. Grier DG, A revolution in optical manipulation, Nature, 2003;424(6950):810-816","journal-title":"Nature"},{"issue":"5(5)","key":"ref11","doi-asserted-by":"publisher","first-page":"51302","DOI":"10.1117\/1.3579200","article-title":"Survey on indirect optical manipulation of cells, nucleic acids, and motor proteins","volume":"16","author":"Banerjee AG, Chowdhury S, Losert W, Gupta SK","year":"2011","unstructured":"11. Banerjee AG, Chowdhury S, Losert W, Gupta SK, Survey on indirect optical manipulation of cells, nucleic acids, and motor proteins, J Biomed Opt, 2011;16(5(5)):51302","journal-title":"J Biomed Opt"},{"issue":"90","key":"ref12","doi-asserted-by":"publisher","DOI":"10.3791\/51446","article-title":"Combining single-molecule manipulation and imaging for the study of protein-DNA interactions","volume":"90","author":"Monico C, Belcastro G, Vanzi F, Pavone FS, Capitanio M","year":"2014","unstructured":"12. Monico C, Belcastro G, Vanzi F, Pavone FS, Capitanio M, Combining single-molecule manipulation and imaging for the study of protein-DNA interactions, J Vis Exp, 2014;90(90):","journal-title":"J Vis Exp"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s43586-021-00021-6","article-title":"Optical tweezers in single-molecule biophysics","volume":"1","author":"Bustamante CJ, Chemla YR, Liu S, Wang MD","year":"2021","unstructured":"13. Bustamante CJ, Chemla YR, Liu S, Wang MD, Optical tweezers in single-molecule biophysics, Nat Rev Methods Primers, 2021;125","journal-title":"Nat Rev Methods Primers"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/ANNUREV.PHYSCHEM.012809.103454","article-title":"Complex fluids: probing mechanical properties of biological systems with optical tweezers","volume":"61","author":"Ou-Yang HD, Wei MT","year":"2010","unstructured":"14. Ou-Yang HD, Wei MT, Complex fluids: probing mechanical properties of biological systems with optical tweezers, Annu Rev Phys Chem, 2010;61421-440","journal-title":"Annu Rev Phys Chem"},{"issue":"1","key":"ref15","doi-asserted-by":"publisher","first-page":"103443","DOI":"10.1016\/J.DRUDIS.2022.103443","article-title":"Optical tweezers for drug discovery","volume":"28","author":"Halma MTJ, Tuszynski JA, Wuite GJL","year":"2023","unstructured":"15. Halma MTJ, Tuszynski JA, Wuite GJL, Optical tweezers for drug discovery, Drug Discov Today, 2023;28(1):103443","journal-title":"Drug Discov Today"},{"issue":"20","key":"ref16","doi-asserted-by":"publisher","first-page":"10244","DOI":"10.3390\/app122010244","article-title":"Holographic optical tweezers: Techniques and biomedical applications","volume":"12","author":"Chen HC, Cheng CJ","year":"2022","unstructured":"16. Chen HC, Cheng CJ, Holographic optical tweezers: Techniques and biomedical applications, Appl Sci, 2022;12(20):10244","journal-title":"Appl Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"602797","DOI":"10.3389\/FBIOE.2020.602797\/BIBTEX","article-title":"Optical Tweezers Exploring Neuroscience","volume":"8","author":"Lenton ICD, Scott EK, Rubinsztein-Dunlop H, Favre-Bulle IA","year":"2020","unstructured":"17. Lenton ICD, Scott EK, Rubinsztein-Dunlop H, Favre-Bulle IA, Optical Tweezers Exploring Neuroscience, Front Bioeng Biotechnol, 2020;8602797","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"ref18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-85013-y","article-title":"Optical Tweezers with Integrated Multiplane Microscopy (OpTIMuM): a new tool for 3D microrheology","volume":"11","author":"Matheson AB, Paterson L, Wright AJ, Mendonca T, Tassieri M, Dalgarno PA","year":"2021","unstructured":"18. Matheson AB, Paterson L, Wright AJ, Mendonca T, Tassieri M, Dalgarno PA, Optical Tweezers with Integrated Multiplane Microscopy (OpTIMuM): a new tool for 3D microrheology, Sci Rep, 2021;11(1):1-9","journal-title":"Sci Rep"},{"issue":"4","key":"ref19","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/JBIO.200910050","article-title":"Optical manipulation for single-cell studies","volume":"3","author":"Ramser K, Hanstorp D","year":"2010","unstructured":"19. Ramser K, Hanstorp D, Optical manipulation for single-cell studies, J Biophotonics, 2010;3(4):187-206","journal-title":"J Biophotonics"},{"issue":"1","key":"ref20","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1039\/b512471a","article-title":"Optical micromanipulation","volume":"37","author":"Dholakia K, Reece P, Gu M","year":"2008","unstructured":"20. Dholakia K, Reece P, Gu M, Optical micromanipulation, Chem Soc Rev, 2008;37(1):42-55","journal-title":"Chem Soc Rev"},{"issue":"9","key":"ref21","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1063\/1.1785844","article-title":"Optical trapping","volume":"75","author":"Neuman KC, Block SM","year":"2004","unstructured":"21. Neuman KC, Block SM, Optical trapping, Rev Sci Instrum, 2004;75(9):2787-809","journal-title":"Rev Sci Instrum"},{"issue":"12","key":"ref22","doi-asserted-by":"publisher","DOI":"10.1140\/EPJP\/S13360-020-00843-5","article-title":"Optical tweezers: theory and practice. The European Physical Journal Plus","volume":"135","author":"Pesce G, Jones PH, Marag\u00f2 OM, Volpe G","year":"2020","unstructured":"22. Pesce G, Jones PH, Marag\u00f2 OM, Volpe G, Optical tweezers: theory and practice. The European Physical Journal Plus, 2020;135(12):"},{"issue":"6","key":"ref23","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1515\/nanoph-2019-0055","article-title":"Optical trapping in vivo: Theory, practice, and applications","volume":"8","author":"Favre-Bulle IA, Stilgoe AB, Scott EK, Rubinsztein-Dunlop H","year":"2019","unstructured":"23. Favre-Bulle IA, Stilgoe AB, Scott EK, Rubinsztein-Dunlop H, Optical trapping in vivo: Theory, practice, and applications, Nanophotonics, 2019;8(6):1023-1040","journal-title":"Nanophotonics"},{"issue":"5-6","key":"ref24","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/0030-4018(95)00753-9","article-title":"Radiation forces on a dielectric sphere in the Rayleigh scattering regime","volume":"124","author":"Harada Y, Asakura T","year":"1996","unstructured":"24. Harada Y, Asakura T, Radiation forces on a dielectric sphere in the Rayleigh scattering regime, Opt Commun, 1996;124(5-6):529-541","journal-title":"Opt Commun"},{"issue":"12","key":"ref25","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1038\/nprot.2007.446","article-title":"Construction and calibration of an optical trap on a fluorescence optical microscope","volume":"2","author":"Lee WM, Reece PJ, Marchington RF, Metzger NK, Dholakia K","year":"2007","unstructured":"25. Lee WM, Reece PJ, Marchington RF, Metzger NK, Dholakia K, Construction and calibration of an optical trap on a fluorescence optical microscope, Nat Protoc, 2007;2(12):3226-3238","journal-title":"Nat Protoc"},{"issue":"1","key":"ref26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1109\/TBME.2002.805463","article-title":"Advanced optical tweezers for the study of cellular and molecular biomechanics","volume":"50","author":"Brouhard GJ, Schek HT, Hunt AJ","year":"2003","unstructured":"26. Brouhard GJ, Schek HT, Hunt AJ, Advanced optical tweezers for the study of cellular and molecular biomechanics, IEEE Trans Biomed Eng, 2003;50(1):121-125","journal-title":"IEEE Trans Biomed Eng"},{"issue":"7(7)","key":"ref27","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1039\/C0LC00526F","article-title":"Holographic optical tweezers and their relevance to lab on chip devices","volume":"11","author":"Padgett M, Di Leonardo R","year":"2011","unstructured":"27. Padgett M, Di Leonardo R, Holographic optical tweezers and their relevance to lab on chip devices, Lab Chip, 2011;11(7(7)):1196-1205","journal-title":"Lab Chip"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1146\/annurev.biochem.77.043007.090225","article-title":"Recent advances in optical tweezers","volume":"77","author":"Moffitt JR, Chemla YR, Smith SB, Bustamante C","year":"2008","unstructured":"28. Moffitt JR, Chemla YR, Smith SB, Bustamante C, Recent advances in optical tweezers, Annu Rev Biochem, 2008;77205-28","journal-title":"Annu Rev Biochem"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/978-1-4939-6421-5_8","article-title":"\u201cFleezers\u201d: Dual-Trap Optical Tweezers Combined with Single-Molecule Fluorescence Detection","volume":"1486","author":"Whitley KD, Comstock MJ, Chemla YR, High-Resolution","year":"2017","unstructured":"29. Whitley KD, Comstock MJ, Chemla YR, High-Resolution, \u201cFleezers\u201d: Dual-Trap Optical Tweezers Combined with Single-Molecule Fluorescence Detection, Methods Mol Biol, 2017;1486183","journal-title":"Methods Mol Biol"},{"issue":"8","key":"ref30","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1364\/OL.486264","article-title":"Completely non-invasive cell manipulation in lens-integrated microfluidic devices by single-fiber optical tweezers","volume":"48","author":"Jiang C, Wang Y, Dong T, Li D, Yan B, Chen P","year":"2023","unstructured":"30. Jiang C, Wang Y, Dong T, Li D, Yan B, Chen P, Completely non-invasive cell manipulation in lens-integrated microfluidic devices by single-fiber optical tweezers, Opt Lett, 2023;48(8):2130-2133","journal-title":"Opt Lett"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"132173","DOI":"10.1016\/j.snb.2022.132173","article-title":"Optical tweezers assisted analyzing and sorting of tumor cells tagged with fluorescence nanospheres in a microfluidic chip","volume":"368","author":"Zheng B, Li CY, Huang S, Zhang ZL, Wu QS, Pang DW","year":"2022","unstructured":"31. Zheng B, Li CY, Huang S, Zhang ZL, Wu QS, Pang DW, Optical tweezers assisted analyzing and sorting of tumor cells tagged with fluorescence nanospheres in a microfluidic chip, Sens Actuators B Chem, 2022;368132173","journal-title":"Sens Actuators B Chem"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/srep01258","article-title":"Integrated microfluidic device for single-cell trapping and spectroscopy","volume":"3","author":"Liberale C, Cojoc G, Bragheri F, Minzioni P, Perozziello G, La Rocca R","year":"2013","unstructured":"32. Liberale C, Cojoc G, Bragheri F, Minzioni P, Perozziello G, La Rocca R, Integrated microfluidic device for single-cell trapping and spectroscopy, Sci Rep, 2013;31258","journal-title":"Sci Rep"},{"issue":"26","key":"ref33","doi-asserted-by":"publisher","first-page":"13095","DOI":"10.1364\/OE.14.013095","article-title":"Automated trapping, assembly, and sorting with holographic optical tweezers","volume":"14","author":"Chapin SC, Germain V, Dufresne ER","year":"2006","unstructured":"33. Chapin SC, Germain V, Dufresne ER, Automated trapping, assembly, and sorting with holographic optical tweezers, Opt Express, 2006;14(26):13095-100","journal-title":"Opt Express"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"8577","DOI":"10.1038\/srep08577","article-title":"Precision assembly of complex cellular microenvironments using holographic optical tweezers","volume":"5","author":"Kirkham GR, Britchford E, Upton T, Ware J, Gibson GM, Devaud Y","year":"2015","unstructured":"34. Kirkham GR, Britchford E, Upton T, Ware J, Gibson GM, Devaud Y, Precision assembly of complex cellular microenvironments using holographic optical tweezers, Sci Rep, 2015;58577","journal-title":"Sci Rep"},{"issue":"16","key":"ref35","doi-asserted-by":"publisher","first-page":"7263","DOI":"10.1039\/C0CP02844D","article-title":"Combining optical trapping, fluorescence microscopy and micro-fluidics for single molecule studies of DNA\u2013protein interactions","volume":"13","author":"Candelli A, Wuite GJL, Peterman EJG","year":"2011","unstructured":"35. Candelli A, Wuite GJL, Peterman EJG, Combining optical trapping, fluorescence microscopy and micro-fluidics for single molecule studies of DNA\u2013protein interactions, Physical Chemistry Chemical Physics, 2011;13(16):7263-7272","journal-title":"Physical Chemistry Chemical Physics"},{"issue":"3","key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24032668","article-title":"Looking at Biomolecular Interactions through the Lens of Correlated Fluorescence Microscopy and Optical Tweezers","volume":"24","author":"Haghizadeh A, Iftikhar M, Dandpat SS, Simpson T","year":"2023","unstructured":"36. Haghizadeh A, Iftikhar M, Dandpat SS, Simpson T, Looking at Biomolecular Interactions through the Lens of Correlated Fluorescence Microscopy and Optical Tweezers, Int J Mol Sci, 2023;24(3):","journal-title":"Int J Mol Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev-biochem-013118-111442","article-title":"Single-Molecule Studies of Protein Folding with Optical Tweezers","volume":"89","author":"Bustamante C, Alexander L, Maciuba K, Kaiser CM","year":"2020","unstructured":"37. Bustamante C, Alexander L, Maciuba K, Kaiser CM, Single-Molecule Studies of Protein Folding with Optical Tweezers, Annu Rev Biochem, 2020;89443-470","journal-title":"Annu Rev Biochem"},{"issue":"21","key":"ref38","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.1039\/c1lc20563e","article-title":"Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies","volume":"11","author":"Wang X, Chen S, Kong M, Wang Z, Costa KD, Li RA","year":"2011","unstructured":"38. Wang X, Chen S, Kong M, Wang Z, Costa KD, Li RA, Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies, Lab Chip, 2011;11(21):3656-3662","journal-title":"Lab Chip"},{"issue":"10","key":"ref39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/PR8101253","article-title":"Recent Development of Microfluidic Technology for Cell Trapping in Single Cell Analysis: A Review","volume":"8","author":"Deng Y, Guo Y, Xu B","year":"2020","unstructured":"39. Deng Y, Guo Y, Xu B, Recent Development of Microfluidic Technology for Cell Trapping in Single Cell Analysis: A Review, Processes, 2020;8(10):1-31","journal-title":"Processes"},{"issue":"5","key":"ref40","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/S12551-019-00599-Y\/METRICS","article-title":"Probing force in living cells with optical tweezers: from single-molecule mechanics to cell mechanotransduction","volume":"11","author":"Arbore C, Perego L, Sergides M, Capitanio M","year":"2019","unstructured":"40. Arbore C, Perego L, Sergides M, Capitanio M, Probing force in living cells with optical tweezers: from single-molecule mechanics to cell mechanotransduction, Biophys Rev, 2019;11(5):765-782","journal-title":"Biophys Rev"},{"issue":"3","key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS9030545","article-title":"Optical Tweezers in Studies of Red Blood Cells","volume":"9","author":"Zhu R, Avsievich T, Popov A, Meglinski I","year":"2020","unstructured":"41. Zhu R, Avsievich T, Popov A, Meglinski I, Optical Tweezers in Studies of Red Blood Cells, Cells, 2020;9(3):","journal-title":"Cells"},{"issue":"1","key":"ref42","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1364\/BOE.6.000118","article-title":"Stretching of red blood cells using an electro-optics trap","volume":"6","author":"Haque MM, Moisescu MG, Valkai S, D\u00e9r A, Savopol T","year":"2014","unstructured":"42. Haque MM, Moisescu MG, Valkai S, D\u00e9r A, Savopol T, Stretching of red blood cells using an electro-optics trap, Biomed Opt Express, 2014;6(1):118-23","journal-title":"Biomed Opt Express"},{"issue":"3","key":"ref43","article-title":"Lab-on-Chip system combined optical tweezers and dielectrophoresis","volume":"23","author":"Mizuta Y, Taguchi K","year":"2015","unstructured":"43. Mizuta Y, Taguchi K, Lab-on-Chip system combined optical tweezers and dielectrophoresis, APSAEM14 J Jpn Soc Appl Electromagn Mech, 2015;23(3):","journal-title":"APSAEM14 J Jpn Soc Appl Electromagn Mech"},{"issue":"23","key":"ref44","doi-asserted-by":"publisher","first-page":"235101","DOI":"10.1088\/1361-648X\/ab76ac","article-title":"Measurement of viscoelastic properties of the cellular cytoplasm using optically trapped Brownian probes","volume":"32","author":"Vaippully R, Ramanujan V, Bajpai S, Roy B","year":"2020","unstructured":"44. Vaippully R, Ramanujan V, Bajpai S, Roy B, Measurement of viscoelastic properties of the cellular cytoplasm using optically trapped Brownian probes, J Phys Condens Matter, 2020;32(23):235101","journal-title":"J Phys Condens Matter"},{"issue":"6","key":"ref45","doi-asserted-by":"publisher","first-page":"65102","DOI":"10.1088\/0957-4484\/27\/6\/065102","article-title":"Investigation into local cell mechanics by atomic force microscopy mapping and optical tweezer vertical indentation","volume":"27","author":"Coceano G, Yousafzai MS, Ma W, Ndoye F, Venturelli L, Hussain I","year":"2016","unstructured":"45. Coceano G, Yousafzai MS, Ma W, Ndoye F, Venturelli L, Hussain I, Investigation into local cell mechanics by atomic force microscopy mapping and optical tweezer vertical indentation, Nanotechnology, 2016;27(6):65102","journal-title":"Nanotechnology"},{"issue":"11","key":"ref46","doi-asserted-by":"publisher","first-page":"111411","DOI":"10.1117\/1.JBO.18.11.111411","article-title":"Localized cell stiffness measurement using axial movement of an optically trapped microparticle","volume":"18","author":"Dy MC, Kanaya S, Sugiura T","year":"2013","unstructured":"46. Dy MC, Kanaya S, Sugiura T, Localized cell stiffness measurement using axial movement of an optically trapped microparticle, J Biomed Opt, 2013;18(11):111411","journal-title":"J Biomed Opt"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"344311","DOI":"10.3389\/FNCEL.2018.00130\/BIBTEX","article-title":"Cell mechanotransduction with piconewton forces applied by optical tweezers","volume":"12","author":"Falleroni F, Torre V, Cojoc D","year":"2018","unstructured":"47. Falleroni F, Torre V, Cojoc D, Cell mechanotransduction with piconewton forces applied by optical tweezers, Front Cell Neurosci, 2018;12344311","journal-title":"Front Cell Neurosci"},{"issue":"17","key":"ref48","doi-asserted-by":"publisher","first-page":"8453","DOI":"10.1039\/C3RA45835K","article-title":"Accurate measurement of stiffness of leukemia cells and leukocytes using an optical trap by a rate-jump method","volume":"4","author":"Zhou ZL, Hui TH, Tang B, Ngan AHW","year":"2014","unstructured":"48. Zhou ZL, Hui TH, Tang B, Ngan AHW, Accurate measurement of stiffness of leukemia cells and leukocytes using an optical trap by a rate-jump method, RSC Adv, 2014;4(17):8453-8460","journal-title":"RSC Adv"},{"issue":"7","key":"ref49","doi-asserted-by":"publisher","first-page":"70602","DOI":"10.1117\/1.JBO.26.7.070602","article-title":"Optical manipulation: advances for biophotonics in the 21st century","volume":"26","author":"Corsetti S, Dholakia K","year":"2021","unstructured":"49. Corsetti S, Dholakia K, Optical manipulation: advances for biophotonics in the 21st century, J Biomed Opt, 2021;26(7):70602","journal-title":"J Biomed Opt"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1591\/ab79ce","article-title":"Tutorial regarding AFM nanoindentation experiments on biological samples Published online 2020","author":"Hertz model or Oliver & Pharr analysis?","unstructured":"50. Hertz model or Oliver & Pharr analysis?, Tutorial regarding AFM nanoindentation experiments on biological samples Published online 2020,"},{"issue":"5","key":"ref51","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/S10237-008-0139-9","article-title":"Spherical indentation of soft matter beyond the Hertzian regime: numerical and experimental validation of hyperelastic models","volume":"8","author":"Lin DC, Shreiber DI, Dimitriadis EK, Horkay F","year":"2009","unstructured":"51. Lin DC, Shreiber DI, Dimitriadis EK, Horkay F, Spherical indentation of soft matter beyond the Hertzian regime: numerical and experimental validation of hyperelastic models, Biomech Model Mechanobiol, 2009;8(5):345","journal-title":"Biomech Model Mechanobiol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"103228","DOI":"10.1016\/j.micron.2021.103228","article-title":"The Hertzian theory in AFM nanoindentation experiments regarding biological samples: Overcoming limitations in data processing","volume":"155","author":"Kontomaris SV, Malamou A, Stylianou A","year":"2022","unstructured":"52. Kontomaris SV, Malamou A, Stylianou A, The Hertzian theory in AFM nanoindentation experiments regarding biological samples: Overcoming limitations in data processing, Micron, 2022;155103228","journal-title":"Micron"},{"issue":"67","key":"ref53","doi-asserted-by":"publisher","DOI":"10.3791\/3886","article-title":"Micropipette Aspiration of Substrate-attached Cells to Estimate Cell Stiffness","author":"Oh MJ, Kuhr F, Byfield F, Levitan I","year":"2012","unstructured":"53. Oh MJ, Kuhr F, Byfield F, Levitan I, Micropipette Aspiration of Substrate-attached Cells to Estimate Cell Stiffness, J Vis Exp, 2012;(67):","journal-title":"J Vis Exp"},{"issue":"76","key":"ref54","doi-asserted-by":"publisher","first-page":"50497","DOI":"10.3791\/50497","article-title":"Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy","author":"Thomas G, Burnham NA, Camesano TA nne, Wen Q","year":"2013","unstructured":"54. Thomas G, Burnham NA, Camesano TA nne, Wen Q, Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy, J Vis Exp, 2013;(76):50497","journal-title":"J Vis Exp"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.optlaseng.2015.02.008","article-title":"Substrate-dependent cell elasticity measured by optical tweezers indentation","volume":"76","author":"Yousafzai MS, Ndoye F, Coceano G, Niemela J, Bonin S, Scoles G","year":"2016","unstructured":"55. Yousafzai MS, Ndoye F, Coceano G, Niemela J, Bonin S, Scoles G, Substrate-dependent cell elasticity measured by optical tweezers indentation, Opt Lasers Eng, 2016;7627-33","journal-title":"Opt Lasers Eng"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"7159","DOI":"10.1038\/ncomms8159","article-title":"The tethering of chromatin to the nuclear envelope supports nuclear mechanics","volume":"6","author":"Schreiner SM, Koo PK, Zhao Y, Mochrie SG, King MC","year":"2015","unstructured":"56. Schreiner SM, Koo PK, Zhao Y, Mochrie SG, King MC, The tethering of chromatin to the nuclear envelope supports nuclear mechanics, Nat Commun, 2015;67159","journal-title":"Nat Commun"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"5881","DOI":"10.1016\/j.actamat.2003.09.001","article-title":"The biomechanics toolbox: experimental approaches for living cells and biomolecules","volume":"51","author":"Van Vliet KJ, Bao G, Suresh S","year":"2003","unstructured":"57. Van Vliet KJ, Bao G, Suresh S, The biomechanics toolbox: experimental approaches for living cells and biomolecules, Acta Mater, 2003;515881-5905","journal-title":"Acta Mater"},{"issue":"3","key":"ref58","first-page":"169","article-title":"Nonlinear elastic and viscoelastic deformation of the human red blood cell with optical tweezers","volume":"1","author":"Mills JP, Qie L, Dao M, Lim CT, Suresh S","year":"2004","unstructured":"58. Mills JP, Qie L, Dao M, Lim CT, Suresh S, Nonlinear elastic and viscoelastic deformation of the human red blood cell with optical tweezers, Mech Chem Biosyst, 2004;1(3):169-180","journal-title":"Mech Chem Biosyst"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"15873","DOI":"10.1038\/srep15873","article-title":"Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique","volume":"6","author":"Agrawal R, Smart T, Nobre-Cardoso J, Richards C, Bhatnagar R, Tufail A","year":"2016","unstructured":"59. Agrawal R, Smart T, Nobre-Cardoso J, Richards C, Bhatnagar R, Tufail A, Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique, Sci Rep, 2016;615873","journal-title":"Sci Rep"},{"issue":"4(4)","key":"ref60","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1006\/BBRC.2001.5426","article-title":"Stretching short biopolymers using optical tweezers","volume":"286","author":"Sun YL, Luo ZP, An KN","year":"2001","unstructured":"60. Sun YL, Luo ZP, An KN, Stretching short biopolymers using optical tweezers, Biochem Biophys Res Commun, 2001;286(4(4)):826-830","journal-title":"Biochem Biophys Res Commun"},{"issue":"5-6","key":"ref61","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1023\/A:1023450204528","article-title":"Optical tweezers stretching of chromatin","volume":"23","author":"Pope LH, Bennink ML, Greve J","year":"2002","unstructured":"61. Pope LH, Bennink ML, Greve J, Optical tweezers stretching of chromatin, J Muscle Res Cell Motil, 2002;23(5-6):397-407","journal-title":"J Muscle Res Cell Motil"},{"issue":"1","key":"ref62","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1021\/LA010913M","article-title":"Biotin-Derivatized Poly(L-lysine)-g-poly(ethylene glycol): A Novel Polymeric Interface for Bioaffinity Sensing","volume":"18","author":"Huang NP, V\u00f6r\u00f6s J, De Paul SM, Textor M, Spencer ND","year":"2002","unstructured":"62. Huang NP, V\u00f6r\u00f6s J, De Paul SM, Textor M, Spencer ND, Biotin-Derivatized Poly(L-lysine)-g-poly(ethylene glycol): A Novel Polymeric Interface for Bioaffinity Sensing, Langmuir, 2002;18(1):220-230","journal-title":"Langmuir"},{"issue":"1-2(1-2)","key":"ref63","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/J.JIM.2009.07.011","article-title":"Specific antibody immobilization with biotin-poly(L-lysine)-g-poly(ethylene glycol) and protein A on microfluidic chips","volume":"350","author":"Wen X, He H, Lee LJ","year":"2009","unstructured":"63. Wen X, He H, Lee LJ, Specific antibody immobilization with biotin-poly(L-lysine)-g-poly(ethylene glycol) and protein A on microfluidic chips, J Immunol Methods, 2009;350(1-2(1-2)):97-105","journal-title":"J Immunol Methods"},{"issue":"8","key":"ref64","doi-asserted-by":"publisher","first-page":"18040","DOI":"10.3390\/S150818040","article-title":"PEG Functionalization of Whispering Gallery Mode Optical Microresonator Biosensors to Minimize Non-Specific Adsorption during Targeted, Label-Free Sensing","volume":"15","author":"Wang F, Anderson M, Bernards MT, Hunt HK","year":"2015","unstructured":"64. Wang F, Anderson M, Bernards MT, Hunt HK, PEG Functionalization of Whispering Gallery Mode Optical Microresonator Biosensors to Minimize Non-Specific Adsorption during Targeted, Label-Free Sensing, Sensors (Basel), 2015;15(8):18040-18060","journal-title":"Sensors (Basel)"},{"issue":"3","key":"ref65","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/S0006-3495(92)81644-2","article-title":"Conformation and elasticity of the isolated red blood cell membrane skeleton","volume":"63","author":"Svoboda K, Schmidt CF, Branton D, Block SM","year":"1992","unstructured":"65. Svoboda K, Schmidt CF, Branton D, Block SM, Conformation and elasticity of the isolated red blood cell membrane skeleton, Biophys J, 1992;63(3):784","journal-title":"Biophys J"},{"issue":"6","key":"ref66","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.1016\/S0006-3495(99)77140-7","article-title":"The deformation of spherical vesicles with permeable, constant-area membranes: application to the red blood cell","volume":"77","author":"Parker KH, Winlove CP","year":"1999","unstructured":"66. Parker KH, Winlove CP, The deformation of spherical vesicles with permeable, constant-area membranes: application to the red blood cell, Biophys J, 1999;77(6):3096-3107","journal-title":"Biophys J"},{"issue":"6","key":"ref67","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1016\/S0006-3495(99)77139-0","article-title":"Elasticity of the red cell membrane and its relation to hemolytic disorders: an optical tweezers study","volume":"77","author":"Sleep J, Wilson D, Simmons R, Gratzer W","year":"1999","unstructured":"67. Sleep J, Wilson D, Simmons R, Gratzer W, Elasticity of the red cell membrane and its relation to hemolytic disorders: an optical tweezers study, Biophys J, 1999;77(6):3085","journal-title":"Biophys J"},{"issue":"1","key":"ref68","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jbiomech.2011.09.007","article-title":"Probing the mechanobiological properties of human embryonic stem cells in cardiac differentiation by optical tweezers","volume":"45","author":"Tan Y, Kong CW, Chen S, Cheng SH, Li RA, Sun D","year":"2012","unstructured":"68. Tan Y, Kong CW, Chen S, Cheng SH, Li RA, Sun D, Probing the mechanobiological properties of human embryonic stem cells in cardiac differentiation by optical tweezers, J Biomech, 2012;45(1):123-128","journal-title":"J Biomech"},{"issue":"6","key":"ref69","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/JMCB\/MJAB021","article-title":"Measurement of dynamic membrane mechanosensation using optical tweezers","volume":"13","author":"Li X, Liu X, Song X, Li Y, Li M, Wang H","year":"2021","unstructured":"69. Li X, Liu X, Song X, Li Y, Li M, Wang H, Measurement of dynamic membrane mechanosensation using optical tweezers, J Mol Cell Biol, 2021;13(6):455-457","journal-title":"J Mol Cell Biol"},{"issue":"8","key":"ref70","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S0006-3495(73)86021-7","article-title":"Measurement of the Elastic Modulus for Red Cell Membrane Using a Fluid Mechanical Technique","volume":"13","author":"Hochmuth RM, Mohandas N, Blackshear PL","year":"1973","unstructured":"70. Hochmuth RM, Mohandas N, Blackshear PL, Measurement of the Elastic Modulus for Red Cell Membrane Using a Fluid Mechanical Technique, Biophys J, 1973;13(8):747-762","journal-title":"Biophys J"},{"issue":"9","key":"ref71","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/S0006-3495(73)86036-9","article-title":"New membrane concept applied to the analysis of fluid shear-and micropipette-deformed red blood cells","volume":"13","author":"Evans EA","year":"1973","unstructured":"71. Evans EA, New membrane concept applied to the analysis of fluid shear-and micropipette-deformed red blood cells, Biophys J, 1973;13(9):941-954","journal-title":"Biophys J"},{"issue":"6","key":"ref72","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0006-3495(76)85713-X","article-title":"Elastic area compressibility modulus of red cell membrane","volume":"16","author":"Evans EA, Waugh R, Melnik L","year":"1976","unstructured":"72. Evans EA, Waugh R, Melnik L, Elastic area compressibility modulus of red cell membrane, Biophys J, 1976;16(6):585-595","journal-title":"Biophys J"},{"issue":"1","key":"ref73","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0006-3495(82)84493-7","article-title":"Extensional flow of erythrocyte membrane from cell body to elastic tether. II. Experiment","volume":"39","author":"Hochmuth RM, Wiles HC, Evans EA, McCown JT","year":"1982","unstructured":"73. Hochmuth RM, Wiles HC, Evans EA, McCown JT, Extensional flow of erythrocyte membrane from cell body to elastic tether. II. Experiment, Biophys J, 1982;39(1):83-89","journal-title":"Biophys J"},{"issue":"1","key":"ref74","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0006-3495(82)84492-5","article-title":"Extensional flow of erythrocyte membrane from cell body to elastic tether. I. Analysis","volume":"39","author":"Hochmuth RM, Evans EA","year":"1982","unstructured":"74. Hochmuth RM, Evans EA, Extensional flow of erythrocyte membrane from cell body to elastic tether. I. Analysis, Biophys J, 1982;39(1):71-81","journal-title":"Biophys J"},{"issue":"3","key":"ref75","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/S0006-3495(95)80274-2","article-title":"Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers","volume":"68","author":"Dai J, Sheetz MP","year":"1995","unstructured":"75. Dai J, Sheetz MP, Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers, Biophys J, 1995;68(3):988-996","journal-title":"Biophys J"},{"issue":"3","key":"ref76","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0006-3495(89)82844-9","article-title":"Determination of bilayer membrane bending stiffness by tether formation from giant, thin-walled vesicles","volume":"55","author":"Bo L, Waugh RE","year":"1989","unstructured":"76. Bo L, Waugh RE, Determination of bilayer membrane bending stiffness by tether formation from giant, thin-walled vesicles, Biophys J, 1989;55(3):509-517","journal-title":"Biophys J"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/978-1-0716-0732-9_15","article-title":"Pulling of Tethers from the Cell Plasma Membrane Using Optical Tweezers","volume":"2169","author":"K\u00f6ster DV","year":"2020","unstructured":"77. K\u00f6ster DV, Pulling of Tethers from the Cell Plasma Membrane Using Optical Tweezers, Methods Mol Biol, 2020;2169167-174","journal-title":"Methods Mol Biol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/J.BBRC.2021.11.081","article-title":"Changes in the properties of membrane tethers in response to HP1\u03b1 depletion in MCF7 cells","volume":"587","author":"Pradhan S, Williams MAK, Hale TK","year":"2022","unstructured":"78. Pradhan S, Williams MAK, Hale TK, Changes in the properties of membrane tethers in response to HP1\u03b1 depletion in MCF7 cells, Biochem Biophys Res Commun, 2022;587126-130","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref79","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1017\/S1551929500055012","article-title":"Single-Molecule DNA Stretching Using Optical Tweezers","volume":"17","author":"van Mameren J, Wozniak A, Ragona S","year":"2009","unstructured":"79. van Mameren J, Wozniak A, Ragona S, Single-Molecule DNA Stretching Using Optical Tweezers, Micros Today, 2009;17(1):42-43","journal-title":"Micros Today"},{"issue":"6","key":"ref80","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1364\/BOE.5.001886","article-title":"Double nanohole optical tweezers visualize protein p53 suppressing unzipping of single DNA-hairpins","volume":"5","author":"Kotnala A, Gordon R","year":"2014","unstructured":"80. Kotnala A, Gordon R, Double nanohole optical tweezers visualize protein p53 suppressing unzipping of single DNA-hairpins, Biomed Opt Express, 2014;5(6):1886","journal-title":"Biomed Opt Express"},{"issue":"5681","key":"ref81","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1126\/science.1100603","article-title":"Molecular biology. Unraveling DNA condensation with optical tweezers","volume":"305","author":"Zhuang X","year":"2004","unstructured":"81. Zhuang X, Molecular biology. Unraveling DNA condensation with optical tweezers, Science, 2004;305(5681):188-90","journal-title":"Science"},{"issue":"6","key":"ref82","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1021\/cr4003006","article-title":"Optical Tweezers Analysis of DNA\u2013Protein Complexes","volume":"114","author":"Heller I, Hoekstra TP, King GA, Peterman EJG, Wuite GJL","year":"2014","unstructured":"82. Heller I, Hoekstra TP, King GA, Peterman EJG, Wuite GJL, Optical Tweezers Analysis of DNA\u2013Protein Complexes, Chem Rev, 2014;114(6):3087-3119","journal-title":"Chem Rev"},{"issue":"3","key":"ref83","doi-asserted-by":"publisher","first-page":"578a","DOI":"10.1016\/j.bpj.2011.11.3148","article-title":"Using DNA Handles in Optical Tweezers Studies of Protein Mechanics","volume":"102","author":"Rezaei N, Miao M, Downing BPB, Keeley FW, Forde NR","year":"2012","unstructured":"83. Rezaei N, Miao M, Downing BPB, Keeley FW, Forde NR, Using DNA Handles in Optical Tweezers Studies of Protein Mechanics, Biophys J, 2012;102(3):578a","journal-title":"Biophys J"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/BIP.22880","article-title":"High-resolution, hybrid optical trapping methods, and their application to nucleic acid processing proteins","author":"Chemla YR","year":"2016","unstructured":"84. Chemla YR, High-resolution, hybrid optical trapping methods, and their application to nucleic acid processing proteins, Biopolymers, 2016;704-714","journal-title":"Biopolymers"},{"issue":"3","key":"ref85","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/S0006-3495(97)78780-0","article-title":"Stretching DNA with optical tweezers","volume":"72","author":"Wang MD, Yin H, Landick R, Gelles J, Block SM","year":"1997","unstructured":"85. Wang MD, Yin H, Landick R, Gelles J, Block SM, Stretching DNA with optical tweezers, Biophys J, 1997;72(3):1335-1346","journal-title":"Biophys J"},{"issue":"3","key":"ref86","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/S0006-3495(02)75506-9","article-title":"Unzipping DNA with Optical Tweezers: High Sequence Sensitivity and Force Flips","volume":"82","author":"Bockelmann U, Thomen Ph, Essevaz-Roulet B, Viasnoff V, Heslot F","year":"2002","unstructured":"86. Bockelmann U, Thomen Ph, Essevaz-Roulet B, Viasnoff V, Heslot F, Unzipping DNA with Optical Tweezers: High Sequence Sensitivity and Force Flips, Biophys J, 2002;82(3):1537-1553","journal-title":"Biophys J"},{"issue":"3","key":"ref87","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0959-440X(00)00085-3","article-title":"Single-molecule studies of DNA mechanics","volume":"10","author":"Bustamante C, Smith SB, Liphardt J, Smith D","year":"2000","unstructured":"87. Bustamante C, Smith SB, Liphardt J, Smith D, Single-molecule studies of DNA mechanics, Curr Opin Struct Biol, 2000;10(3):279-285","journal-title":"Curr Opin Struct Biol"},{"issue":"1","key":"ref88","doi-asserted-by":"publisher","first-page":"e54440","DOI":"10.1371\/JOURNAL.PONE.0054440","article-title":"A Polypeptide-DNA Hybrid with Selective Linking Capability Applied to Single Molecule Nano-Mechanical Measurements Using Optical Tweezers","volume":"8","author":"Moayed F, Mashaghi A, Tans SJ","year":"2013","unstructured":"88. Moayed F, Mashaghi A, Tans SJ, A Polypeptide-DNA Hybrid with Selective Linking Capability Applied to Single Molecule Nano-Mechanical Measurements Using Optical Tweezers, PLoS One, 2013;8(1):e54440","journal-title":"PLoS One"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1117\/12.44242","article-title":"Manipulation of single-DNA molecules and measurements of their elastic properties under an optical microscope","volume":"1435","author":"Bustamante CJ, Finzi L, Sebring PE, Smith SB","year":"1991","unstructured":"89. Bustamante CJ, Finzi L, Sebring PE, Smith SB, Manipulation of single-DNA molecules and measurements of their elastic properties under an optical microscope, Optical Methods for Ultrasensitive Detection and Analysis: Techniques and Applications, 1991;1435179-187","journal-title":"Optical Methods for Ultrasensitive Detection and Analysis: Techniques and Applications"},{"issue":"2","key":"ref90","doi-asserted-by":"publisher","first-page":"262a","DOI":"10.1016\/j.bpj.2012.11.1473","article-title":"Determining the Elasticity of Short DNA Fragments using Optical Tweezers and Protein-Mediated DNA Loop Formation Assays","volume":"104","author":"Kandinov A, Raghunathan K, Meiners JC","year":"2013","unstructured":"90. Kandinov A, Raghunathan K, Meiners JC, Determining the Elasticity of Short DNA Fragments using Optical Tweezers and Protein-Mediated DNA Loop Formation Assays, Biophys J, 2013;104(2):262a","journal-title":"Biophys J"},{"issue":"12","key":"ref91","doi-asserted-by":"publisher","first-page":"4360","DOI":"10.1529\/BIOPHYSJ.107.112995","article-title":"Elasticity of Short DNA Molecules: Theory and Experiment for Contour Lengths of 0.6\u20137 \u00b5m","volume":"93","author":"Seol Y, Li J, Nelson PC, Perkins TT, Betterton MD","year":"2007","unstructured":"91. Seol Y, Li J, Nelson PC, Perkins TT, Betterton MD, Elasticity of Short DNA Molecules: Theory and Experiment for Contour Lengths of 0.6\u20137 \u00b5m, Biophys J, 2007;93(12):4360-4373","journal-title":"Biophys J"},{"issue":"6","key":"ref92","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1016\/S0006-3495(02)75658-0","article-title":"Salt Dependence of the Elasticity and Overstretching Transition of Single DNA Molecules","volume":"82","author":"Wenner JR, Williams MC, Rouzina I, Bloomfield VA","year":"2002","unstructured":"92. Wenner JR, Williams MC, Rouzina I, Bloomfield VA, Salt Dependence of the Elasticity and Overstretching Transition of Single DNA Molecules, Biophys J, 2002;82(6):3160-3169","journal-title":"Biophys J"},{"issue":"4","key":"ref93","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/S0006-3495(00)76744-0","article-title":"Stretching of Single Collapsed DNA Molecules","volume":"78","author":"Baumann CG, Bloomfield VA, Smith SB, Bustamante C, Wang MD, Block SM","year":"2000","unstructured":"93. Baumann CG, Bloomfield VA, Smith SB, Bustamante C, Wang MD, Block SM, Stretching of Single Collapsed DNA Molecules, Biophys J, 2000;78(4):1965-1978","journal-title":"Biophys J"},{"issue":"3","key":"ref94","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1093\/nar\/gkx1252","article-title":"Single-molecule DNA unzipping reveals asymmetric modulation of a transcription factor by its binding site sequence and context","volume":"46","author":"Rudnizky S, Khamis H, Malik O, Squires AH, Meller A, Melamed P","year":"2018","unstructured":"94. Rudnizky S, Khamis H, Malik O, Squires AH, Meller A, Melamed P, Single-molecule DNA unzipping reveals asymmetric modulation of a transcription factor by its binding site sequence and context, Nucleic Acids Res, 2018;46(3):1513-1524","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"ref95","doi-asserted-by":"publisher","first-page":"8608","DOI":"10.1073\/pnas.151257598","article-title":"Force and kinetic barriers to unzipping of the DNA double helix","volume":"98","author":"Cocco S, Monasson R, Marko JF","year":"2001","unstructured":"95. Cocco S, Monasson R, Marko JF, Force and kinetic barriers to unzipping of the DNA double helix, Proc Natl Acad Sci U S A, 2001;98(15):8608-13","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1403.3921","article-title":"Nanoplasmonic tweezers visualize protein p53 suppressing unzipping of single DNA-hairpins","author":"Kotnala A, Gordon R","year":"2014","unstructured":"96. Kotnala A, Gordon R, Nanoplasmonic tweezers visualize protein p53 suppressing unzipping of single DNA-hairpins, arXiv [physics.bio-ph], 2014;Available from:","journal-title":"arXiv [physics.bio-ph]"},{"issue":"24","key":"ref97","doi-asserted-by":"publisher","first-page":"248106","DOI":"10.1103\/PhysRevLett.103.248106","article-title":"Statistical Properties of Metastable Intermediates in DNA Unzipping","volume":"103","author":"Huguet JM, Forns N, Ritort F","year":"2009","unstructured":"97. Huguet JM, Forns N, Ritort F, Statistical Properties of Metastable Intermediates in DNA Unzipping, Phys Rev Lett, 2009;103(24):248106","journal-title":"Phys Rev Lett"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/978-1-4939-8556-2_19","article-title":"Measuring Unzipping and Rezipping of Single Long DNA Molecules with Optical Tweezers","volume":"1805","author":"delToro DJ, Smith DE","year":"2018","unstructured":"98. delToro DJ, Smith DE, Measuring Unzipping and Rezipping of Single Long DNA Molecules with Optical Tweezers, Methods Mol Biol, 2018;1805371-392","journal-title":"Methods Mol Biol"},{"issue":"15","key":"ref99","doi-asserted-by":"publisher","first-page":"8654","DOI":"10.1073\/pnas.1133178100","article-title":"Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases","volume":"100","author":"Stone MD, Bryant Z, Crisona NJ, Smith SB, Vologodskii A, Bustamante C","year":"2003","unstructured":"99. Stone MD, Bryant Z, Crisona NJ, Smith SB, Vologodskii A, Bustamante C, Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases, Proc Natl Acad Sci U S A, 2003;100(15):8654-9","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-0716-2229-2_9","article-title":"Generating Negatively Supercoiled DNA Using Dual-Trap Optical Tweezers","volume":"2478","author":"King GA, Spakman D, Peterman EJG, Wuite GJL","year":"2022","unstructured":"100. King GA, Spakman D, Peterman EJG, Wuite GJL, Generating Negatively Supercoiled DNA Using Dual-Trap Optical Tweezers, Methods Mol Biol, 2022;2478243-272","journal-title":"Methods Mol Biol"},{"issue":"19","key":"ref101","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1016\/j.molcel.2023.09.008","article-title":"Negative DNA supercoiling induces genome-wide Cas9 off-target activity","volume":"83","author":"Newton MD, Losito M, Smith QM, Parnandi N, Taylor BJ, Akcakaya P","year":"2023","unstructured":"101. Newton MD, Losito M, Smith QM, Parnandi N, Taylor BJ, Akcakaya P, Negative DNA supercoiling induces genome-wide Cas9 off-target activity, Mol Cell, 2023;83(19):3533-3545.e5","journal-title":"Mol Cell"},{"issue":"52","key":"ref102","doi-asserted-by":"publisher","first-page":"26534","DOI":"10.1073\/PNAS.1908826116\/SUPPL_FILE\/PNAS.1908826116.SD05.XLSX","article-title":"Supercoiling DNA optically","volume":"116","author":"King GA, Burla F, Peterman EJG, Wuite GJL","year":"2019","unstructured":"102. King GA, Burla F, Peterman EJG, Wuite GJL, Supercoiling DNA optically, Proc Natl Acad Sci U S A, 2019;116(52):26534-26539","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/978-1-4939-8556-2_16","article-title":"Single-Molecule Angular Optical Trapping for Studying Transcription Under Torsion","volume":"1805","author":"Ma J, Tan C, Wang MD","year":"2018","unstructured":"103. Ma J, Tan C, Wang MD, Single-Molecule Angular Optical Trapping for Studying Transcription Under Torsion, Methods Mol Biol, 2018;1805301-332","journal-title":"Methods Mol Biol"},{"issue":"7","key":"ref104","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.1021\/nl301330h","article-title":"Electromagnetic Torque Tweezers: A Versatile Approach for Measurement of Single-Molecule Twist and Torque","volume":"12","author":"Janssen XJA, Lipfert J, Jager T, Daudey R, Beekman J, Dekker NH","year":"2012","unstructured":"104. Janssen XJA, Lipfert J, Jager T, Daudey R, Beekman J, Dekker NH, Electromagnetic Torque Tweezers: A Versatile Approach for Measurement of Single-Molecule Twist and Torque, Nano Lett, 2012;12(7):3634-3639","journal-title":"Nano Lett"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"102868","DOI":"10.1016\/J.SBI.2024.102868","article-title":"DNA topology: A central dynamic coordinator in chromatin regulation","volume":"87","author":"Li S, Vemuri C, Chen C","year":"2024","unstructured":"105. Li S, Vemuri C, Chen C, DNA topology: A central dynamic coordinator in chromatin regulation, Curr Opin Struct Biol, 2024;87102868","journal-title":"Curr Opin Struct Biol"},{"issue":"1","key":"ref106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-11214-z","article-title":"Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers","volume":"7","author":"Hao Y, Canavan C, Taylor SS, Maillard RA","year":"2017","unstructured":"106. Hao Y, Canavan C, Taylor SS, Maillard RA, Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers, Sci Rep, 2017;7(1):1-8","journal-title":"Sci Rep"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/978-1-0716-2229-2_16","article-title":"Tethering Complex Proteins and Protein Complexes for Optical Tweezers Experiments","volume":"2478","author":"Maciuba K, Kaiser CM","year":"2022","unstructured":"107. Maciuba K, Kaiser CM, Tethering Complex Proteins and Protein Complexes for Optical Tweezers Experiments, Methods Mol Biol, 2022;2478427-460","journal-title":"Methods Mol Biol"},{"issue":"5242","key":"ref108","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1126\/SCIENCE.270.5242.1653","article-title":"Transcription against an applied force","volume":"270","author":"Yin H, Wang MD, Svoboda K, Landick R, Block SM, Gelles J","year":"1995","unstructured":"108. Yin H, Wang MD, Svoboda K, Landick R, Block SM, Gelles J, Transcription against an applied force, Science, 1995;270(5242):1653-1657","journal-title":"Science"},{"issue":"5390","key":"ref109","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1126\/science.282.5390.902","article-title":"Force and velocity measured for single molecules of RNA polymerase","volume":"282","author":"Wang MD, Schnitzer MJ, Yin H, Landick R, Gelles J, Block SM","year":"1998","unstructured":"109. Wang MD, Schnitzer MJ, Yin H, Landick R, Gelles J, Block SM, Force and velocity measured for single molecules of RNA polymerase, Science, 1998;282(5390):902-7","journal-title":"Science"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/bs.mie.2016.09.047","article-title":"Recent Advances in Biological Single-Molecule Applications of Optical Tweezers and Fluorescence Microscopy","volume":"582","author":"Hashemi Shabestari M, Meijering AEC, Roos WH, Wuite GJL, Peterman EJG","year":"2017","unstructured":"110. Hashemi Shabestari M, Meijering AEC, Roos WH, Wuite GJL, Peterman EJG, Recent Advances in Biological Single-Molecule Applications of Optical Tweezers and Fluorescence Microscopy, Methods Enzymol, 2017;58285-119","journal-title":"Methods Enzymol"},{"issue":"9","key":"ref111","doi-asserted-by":"publisher","first-page":"93708","DOI":"10.1063\/1.4752190","article-title":"Combined versatile high-resolution optical tweezers and single-molecule fluorescence microscopy","volume":"83","author":"Sirinakis G, Ren Y, Gao Y, Xi Z, Zhang Y","year":"2012","unstructured":"111. Sirinakis G, Ren Y, Gao Y, Xi Z, Zhang Y, Combined versatile high-resolution optical tweezers and single-molecule fluorescence microscopy, Rev Sci Instrum, 2012;83(9):93708","journal-title":"Rev Sci Instrum"},{"issue":"44","key":"ref112","doi-asserted-by":"publisher","first-page":"9612","DOI":"10.1021\/acs.jpca.9b08282","article-title":"Combined High-Resolution Optical Tweezers and Multicolor Single-Molecule Fluorescence with an Automated Single-Molecule Assembly Line","volume":"123","author":"Chuang CY, Zammit M, Whitmore ML, Comstock MJ","year":"2019","unstructured":"112. Chuang CY, Zammit M, Whitmore ML, Comstock MJ, Combined High-Resolution Optical Tweezers and Multicolor Single-Molecule Fluorescence with an Automated Single-Molecule Assembly Line, J Phys Chem A, 2019;123(44):9612-9620","journal-title":"J Phys Chem A"},{"issue":"2","key":"ref113","doi-asserted-by":"publisher","first-page":"232a","DOI":"10.1016\/j.bpj.2014.11.1285","article-title":"Combined Magneto-Optical Tweezers and Supperesolution Fluorescence Imaging for Probing Dynamic Single-Molecule Topology of DNA, and Protein Machines that Manipulate DNA Topology","volume":"108","author":"Leake MC","year":"2015","unstructured":"113. Leake MC, Combined Magneto-Optical Tweezers and Supperesolution Fluorescence Imaging for Probing Dynamic Single-Molecule Topology of DNA, and Protein Machines that Manipulate DNA Topology, Biophys J, 2015;108(2):232a-233a","journal-title":"Biophys J"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/978-1-4939-0329-0_10","article-title":"An improved optical tweezers assay for measuring the force generation of single kinesin molecules","volume":"1136","author":"Nicholas MP, Rao L, Gennerich A","year":"2014","unstructured":"114. Nicholas MP, Rao L, Gennerich A, An improved optical tweezers assay for measuring the force generation of single kinesin molecules, Methods Mol Biol, 2014;1136171-246","journal-title":"Methods Mol Biol"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/B978-012164730-8\/50132-5","article-title":"Optical tweezers: Application to the study of motor proteins","volume":"3","author":"Steffen W, Lewalle A, Sleep J, Celis JE","year":"2006","unstructured":"115. Steffen W, Lewalle A, Sleep J, Celis JE, Optical tweezers: Application to the study of motor proteins, Cell Biology: A Laboratory Handbook, 2006;337-45","journal-title":"Cell Biology: A Laboratory Handbook"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/978-1-4939-6421-5_21","article-title":"Measuring Molecular Forces Using Calibrated Optical Tweezers in Living Cells","volume":"1486","author":"Hendricks AG, Goldman YE","year":"2017","unstructured":"116. Hendricks AG, Goldman YE, Measuring Molecular Forces Using Calibrated Optical Tweezers in Living Cells, Methods Mol Biol, 2017;1486537-552","journal-title":"Methods Mol Biol"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1146\/ANNUREV.PH.58.030196.003503","article-title":"The kinetic cycles of myosin, kinesin, and dynein","volume":"58","author":"Hackney DD","year":"1996","unstructured":"117. Hackney DD, The kinetic cycles of myosin, kinesin, and dynein, Annu Rev Physiol, 1996;58731-750","journal-title":"Annu Rev Physiol"},{"issue":"6448","key":"ref118","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/365721a0","article-title":"Direct observation of kinesin stepping by optical trapping interferometry","volume":"365","author":"Svoboda K, Schmidt CF, Schnapp BJ, Block SM","year":"1993","unstructured":"118. Svoboda K, Schmidt CF, Schnapp BJ, Block SM, Direct observation of kinesin stepping by optical trapping interferometry, Nature, 1993;365(6448):721-727","journal-title":"Nature"},{"issue":"5","key":"ref119","doi-asserted-by":"publisher","first-page":"4342","DOI":"10.1021\/ACS.CHEMREV.6B00638\/ASSET\/IMAGES\/LARGE\/CR-2016-00638H_0018.JPEG","article-title":"Manipulation and Motion of Organelles and Single Molecules in Living Cells","volume":"117","author":"Norregaard K, Metzler R, Ritter CM, Berg-S\u00f8rensen K, Oddershede LB","year":"2017","unstructured":"119. Norregaard K, Metzler R, Ritter CM, Berg-S\u00f8rensen K, Oddershede LB, Manipulation and Motion of Organelles and Single Molecules in Living Cells, Chem Rev, 2017;117(5):4342-4375","journal-title":"Chem Rev"},{"issue":"9","key":"ref120","doi-asserted-by":"publisher","DOI":"10.3390\/MI9090434","article-title":"Single Cell Isolation Using Optical Tweezers","volume":"9","author":"Keloth A, Anderson O, Risbridger D, Paterson L","year":"2018","unstructured":"120. Keloth A, Anderson O, Risbridger D, Paterson L, Single Cell Isolation Using Optical Tweezers, Micromachines (Basel), 2018;9(9):","journal-title":"Micromachines (Basel)"},{"issue":"2(2)","key":"ref121","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1364\/BOE.9.000771","article-title":"Optical tweezers system for live stem cell organization at the single-cell level","volume":"9","author":"Jing P, Liu Y, Keeler EG, Cruz NM, Freedman BS, Lin LY","year":"2018","unstructured":"121. Jing P, Liu Y, Keeler EG, Cruz NM, Freedman BS, Lin LY, Optical tweezers system for live stem cell organization at the single-cell level, Biomed Opt Express, 2018;9(2(2)):771-779","journal-title":"Biomed Opt Express"},{"issue":"17(17)","key":"ref122","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1039\/C2LC21099A","article-title":"Microfluidic sorting of arbitrary cells with dynamic optical tweezers","volume":"12","author":"Landenberger B, H\u00f6femann H, Wadle S, Rohrbach A","year":"2012","unstructured":"122. Landenberger B, H\u00f6femann H, Wadle S, Rohrbach A, Microfluidic sorting of arbitrary cells with dynamic optical tweezers, Lab Chip, 2012;12(17(17)):3177-3183","journal-title":"Lab Chip"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/J.OPTLASENG.2013.11.001","article-title":"Living cell manipulation in a microfluidic device by femtosecond optical tweezers","volume":"55","author":"Li Y, Guo Z, Qu S","year":"2014","unstructured":"123. Li Y, Guo Z, Qu S, Living cell manipulation in a microfluidic device by femtosecond optical tweezers, Opt Lasers Eng, 2014;55150-154","journal-title":"Opt Lasers Eng"},{"issue":"3","key":"ref124","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1109\/TASE.2013.2289311","article-title":"Rapidly exploring random tree algorithm-based path planning for robot-aided optical manipulation of biological cells","volume":"11","author":"Ju T, Liu S, Yang J, Sun D","year":"2014","unstructured":"124. Ju T, Liu S, Yang J, Sun D, Rapidly exploring random tree algorithm-based path planning for robot-aided optical manipulation of biological cells, IEEE Trans Autom Sci Eng, 2014;11(3):649-657","journal-title":"IEEE Trans Autom Sci Eng"},{"issue":"3","key":"ref125","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1109\/MRA.2014.2332407","article-title":"Optical Tweezers: Autonomous Robots for the Manipulation of Biological Cells","volume":"21","author":"Banerjee A, Chowdhury S, Gupta SK","year":"2014","unstructured":"125. Banerjee A, Chowdhury S, Gupta SK, Optical Tweezers: Autonomous Robots for the Manipulation of Biological Cells, IEEE Robotics Autom Mag, 2014;21(3):81-88","journal-title":"IEEE Robotics Autom Mag"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.3389\/FBIOE.2020.00921\/PDF","article-title":"The Combination of Immunomagnetic Bead-Based Cell Isolation and Optically Induced Dielectrophoresis (ODEP)-Based Microfluidic Device for the Negative Selection-Based Isolation of Circulating Tumor Cells (CTCs)","volume":"8","author":"Chu PY, Hsieh CH, Wu MH","year":"2020","unstructured":"126. Chu PY, Hsieh CH, Wu MH, The Combination of Immunomagnetic Bead-Based Cell Isolation and Optically Induced Dielectrophoresis (ODEP)-Based Microfluidic Device for the Negative Selection-Based Isolation of Circulating Tumor Cells (CTCs), Front Bioeng Biotechnol, 2020;8","journal-title":"Front Bioeng Biotechnol"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"32851","DOI":"10.1038\/srep32851","article-title":"Application of optically-induced-dielectrophoresis in microfluidic system for purification of circulating tumour cells for gene expression analysis-Cancer cell line model","volume":"6","author":"Chiu TK, Chou WP, Huang SB, Wang HM, Lin YC, Hsieh CH","year":"2016","unstructured":"127. Chiu TK, Chou WP, Huang SB, Wang HM, Lin YC, Hsieh CH, Application of optically-induced-dielectrophoresis in microfluidic system for purification of circulating tumour cells for gene expression analysis-Cancer cell line model, Sci Rep, 2016;632851","journal-title":"Sci Rep"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.snb.2018.11.129","article-title":"Utilization of optically induced dielectrophoresis in a microfluidic system for sorting and isolation of cells with varied degree of viability: Demonstration of the sorting and isolation of drug-treated cancer cells with various degrees of anti-cancer drug resistance gene expression","volume":"283","author":"Chu PY, Liao CJ, Hsieh CH, Wang HM, Chou WP, Chen PH","year":"2019","unstructured":"128. Chu PY, Liao CJ, Hsieh CH, Wang HM, Chou WP, Chen PH, Utilization of optically induced dielectrophoresis in a microfluidic system for sorting and isolation of cells with varied degree of viability: Demonstration of the sorting and isolation of drug-treated cancer cells with various degrees of anti-cancer drug resistance gene expression, Sens Actuators B Chem, 2019;283621-631","journal-title":"Sens Actuators B Chem"},{"issue":"1","key":"ref129","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1039\/d2lc00888b","article-title":"Versatile, facile and low-cost single-cell isolation, culture and sequencing by optical tweezer-assisted pool-screening","volume":"23","author":"Xu T, Li Y, Han X, Kan L, Ren J, Sun L","year":"2022","unstructured":"129. Xu T, Li Y, Han X, Kan L, Ren J, Sun L, Versatile, facile and low-cost single-cell isolation, culture and sequencing by optical tweezer-assisted pool-screening, Lab Chip, 2022;23(1):125-135","journal-title":"Lab Chip"},{"issue":"1","key":"ref130","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/s41467-018-03156-5","article-title":"Sculpting nanoparticle dynamics for single-bacteria-level screening and direct binding-efficiency measurement","volume":"9","author":"Shi YZ, Xiong S, Zhang Y, Chin LK, Chen Y-, Zhang JB","year":"2018","unstructured":"130. Shi YZ, Xiong S, Zhang Y, Chin LK, Chen Y-, Zhang JB, Sculpting nanoparticle dynamics for single-bacteria-level screening and direct binding-efficiency measurement, Nat Commun, 2018;9(1):815","journal-title":"Nat Commun"},{"issue":"5","key":"ref131","doi-asserted-by":"publisher","first-page":"2100197","DOI":"10.1002\/lpor.202100197","article-title":"Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities","volume":"16","author":"Shi Y, Wu Y, Chin LK, Li Z, Liu J, Chen MK","year":"2022","unstructured":"131. Shi Y, Wu Y, Chin LK, Li Z, Liu J, Chen MK, Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities, Laser Photonics Rev, 2022;16(5):2100197","journal-title":"Laser Photonics Rev"},{"issue":"1","key":"ref132","doi-asserted-by":"publisher","first-page":"eaao0773","DOI":"10.1126\/sciadv.aao0773","article-title":"Nanometer-precision linear sorting with synchronized optofluidic dual barriers","volume":"4","author":"Shi Y, Xiong S, Chin LK, Zhang J, Ser W, Wu J","year":"2018","unstructured":"132. Shi Y, Xiong S, Chin LK, Zhang J, Ser W, Wu J, Nanometer-precision linear sorting with synchronized optofluidic dual barriers, Sci Adv, 2018;4(1):eaao0773","journal-title":"Sci Adv"},{"issue":"1","key":"ref133","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41598-019-56898-7","article-title":"Single-cell adhesion force kinetics of cell populations from combined label-free optical biosensor and robotic fluidic force microscopy","volume":"10","author":"Sztilkovics M, Gerecsei T, Peter B, Saftics A, Kurunczi S, Szekacs I","year":"2020","unstructured":"133. Sztilkovics M, Gerecsei T, Peter B, Saftics A, Kurunczi S, Szekacs I, Single-cell adhesion force kinetics of cell populations from combined label-free optical biosensor and robotic fluidic force microscopy, Sci Rep, 2020;10(1):61","journal-title":"Sci Rep"},{"issue":"12","key":"ref134","doi-asserted-by":"publisher","first-page":"e15215","DOI":"10.1371\/journal.pone.0015215","article-title":"Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions","volume":"5","author":"Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ","year":"2010","unstructured":"134. Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ, Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions, PLoS One, 2010;5(12):e15215","journal-title":"PLoS One"},{"issue":"53","key":"ref135","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.3791\/3123","article-title":"Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging","volume":"28","author":"Tam JM, Castro CE, Heath RJ, Mansour MK, Cardenas ML, Xavier RJ","year":"2011","unstructured":"135. Tam JM, Castro CE, Heath RJ, Mansour MK, Cardenas ML, Xavier RJ, Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging, J Vis Exp, 2011;28(53):3123","journal-title":"J Vis Exp"},{"issue":"3","key":"ref136","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/jbio.201200057","article-title":"Towards 3D modelling and imaging of infection scenarios at the single cell level using holographic optical tweezers and digital holographic microscopy","volume":"6","author":"Kemper B, Barroso \u00c1, Woerdemann M, Dewenter L, Vollmer A, Schubert R","year":"2013","unstructured":"136. Kemper B, Barroso \u00c1, Woerdemann M, Dewenter L, Vollmer A, Schubert R, Towards 3D modelling and imaging of infection scenarios at the single cell level using holographic optical tweezers and digital holographic microscopy, J Biophotonics, 2013;6(3):260-6","journal-title":"J Biophotonics"},{"issue":"4(4)","key":"ref137","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/J.BPJ.2014.07.010","article-title":"Quantitation of malaria parasite-erythrocyte cell-cell interactions using optical tweezers","volume":"107","author":"Crick AJ, Theron M, Tiffert T, Lew VL, Cicuta P, Rayner JC","year":"2014","unstructured":"137. Crick AJ, Theron M, Tiffert T, Lew VL, Cicuta P, Rayner JC, Quantitation of malaria parasite-erythrocyte cell-cell interactions using optical tweezers, Biophys J, 2014;107(4(4)):846-853","journal-title":"Biophys J"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/978-1-4939-7389-7_13","article-title":"Using Optical Tweezers Combined with Total Internal Reflection Microscopy to Study Interactions Between the ER and Golgi in Plant Cells","volume":"1691","author":"Sparkes I, White RR, Coles B, Botchway SW, Ward A","year":"2018","unstructured":"138. Sparkes I, White RR, Coles B, Botchway SW, Ward A, Using Optical Tweezers Combined with Total Internal Reflection Microscopy to Study Interactions Between the ER and Golgi in Plant Cells, Methods Mol Biol, 2018;1691167-178","journal-title":"Methods Mol Biol"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1117\/12.559537","article-title":"The study of adhesive forces between the type-3 fimbriae of Klebsiella pneumoniae and collagen-coated surfaces by using optical tweezers","volume":"5514","author":"Chan C, Fan CC, Huang YJ, Peng HL, Long H, Dholakia K, Spalding GC","year":"2004","unstructured":"139. Chan C, Fan CC, Huang YJ, Peng HL, Long H, Dholakia K, Spalding GC, The study of adhesive forces between the type-3 fimbriae of Klebsiella pneumoniae and collagen-coated surfaces by using optical tweezers, Optical Trapping and Optical Micromanipulation. Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series, 2004;5514724-731","journal-title":"Optical Trapping and Optical Micromanipulation. Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"80970J","DOI":"10.1117\/12.895232","article-title":"Viability studies of optically trapped T-cells","volume":"8097","author":"McAlinden N, Glass DG, Millington O, Wright AJ, Dholakia K, Spalding GC","year":"2011","unstructured":"140. McAlinden N, Glass DG, Millington O, Wright AJ, Dholakia K, Spalding GC, Viability studies of optically trapped T-cells, Optical Trapping and Optical Micromanipulation VIII. Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series, 2011;809780970J","journal-title":"Optical Trapping and Optical Micromanipulation VIII. Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series"},{"issue":"8","key":"ref141","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/nnano.2014.140","article-title":"Optical trapping of individual human immunodeficiency viruses in culture fluid reveals heterogeneity with single-molecule resolution","volume":"9","author":"Pang Y, Song H, Kim JH, Hou X, Cheng W","year":"2014","unstructured":"141. Pang Y, Song H, Kim JH, Hou X, Cheng W, Optical trapping of individual human immunodeficiency viruses in culture fluid reveals heterogeneity with single-molecule resolution, Nat Nanotechnol, 2014;9(8):624-630","journal-title":"Nat Nanotechnol"},{"issue":"3","key":"ref142","first-page":"221","article-title":"Application of optical tweezers in the research of molecular interaction between lymphocyte function associated antigen-1 and its monoclonal antibody","volume":"4","author":"Chen HD, Ge KK, Li YM, Wu JG, Gu YQ, Wei HM","year":"2007","unstructured":"142. Chen HD, Ge KK, Li YM, Wu JG, Gu YQ, Wei HM, Application of optical tweezers in the research of molecular interaction between lymphocyte function associated antigen-1 and its monoclonal antibody, Cell Mol Immunol, 2007;4(3):221-5","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"ref143","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0015-0282(16)56663-1","article-title":"Zona drilling and sperm insertion with combined laser microbeam and optical tweezers","volume":"61","author":"Sch\u00fctze K, Clement-Sengewald A, Ashkin A","year":"1994","unstructured":"143. Sch\u00fctze K, Clement-Sengewald A, Ashkin A, Zona drilling and sperm insertion with combined laser microbeam and optical tweezers, Fertil Steril, 1994;61(4):783-786","journal-title":"Fertil Steril"},{"issue":"8","key":"ref144","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/mi10080507","article-title":"Optical Tweezers: Phototoxicity and Thermal Stress in Cells and Biomolecules","volume":"10","author":"Bl\u00e1zquez-Castro A","year":"2019","unstructured":"144. Bl\u00e1zquez-Castro A, Optical Tweezers: Phototoxicity and Thermal Stress in Cells and Biomolecules, Micromachines (Basel), 2019;10(8):507","journal-title":"Micromachines (Basel)"},{"issue":"1","key":"ref145","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-15904-6","article-title":"Influence of experimental parameters on the laser heating of an optical trap","volume":"7","author":"Catal\u00e0 F, Mars\u00e0 F, Montes-Usategui M, Farr\u00e9 A, Mart\u00edn-Badosa E","year":"2017","unstructured":"145. Catal\u00e0 F, Mars\u00e0 F, Montes-Usategui M, Farr\u00e9 A, Mart\u00edn-Badosa E, Influence of experimental parameters on the laser heating of an optical trap, Sci Rep, 2017;7(1):1-9","journal-title":"Sci Rep"},{"issue":"2","key":"ref146","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1529\/BIOPHYSJ.104.054536","article-title":"Temperature Control Methods in a Laser Tweezers System","volume":"89","author":"Mao H, Arias-Gonzalez JR, Smith SB, Tinoco I, Bustamante C","year":"2005","unstructured":"146. Mao H, Arias-Gonzalez JR, Smith SB, Tinoco I, Bustamante C, Temperature Control Methods in a Laser Tweezers System, Biophys J, 2005;89(2):1308-1316","journal-title":"Biophys J"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/all-issues\/2024\/issue-11-2024\/review-issue-11-2024\/optical-tweezers-in-biomedical-research-progress-and-techniques\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T22:45:26Z","timestamp":1737672326000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/all-issues\/2024\/issue-11-2024\/review-issue-11-2024\/optical-tweezers-in-biomedical-research-progress-and-techniques\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":146,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["JMedLife-17-978"],"URL":"https:\/\/doi.org\/10.25122\/jml-2024-0316","relation":{},"ISSN":["1844-3117"],"issn-type":[{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}