{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:23:58Z","timestamp":1782854638533,"version":"3.54.5"},"reference-count":60,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMedLife"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.25122\/jml-2025-0087","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:50:52Z","timestamp":1752076252000},"page":"387-392","source":"Crossref","is-referenced-by-count":1,"title":["Cost-effectiveness of Cerebrolysin as an add-on treatment for neurorecovery after traumatic brain injury"],"prefix":"10.25122","volume":"18","author":[{"given":"Diana Alecsandra","family":"Grad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Strilciuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Genomics, MEDFUTURE Institute for Biomedical Research, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Vl\u0103descu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"National Institute for Management of Health Services, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Dana","family":"Buzoianu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Albu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Neurology, University of Medicine and Pharmacy, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Neurology, Neuropsychiatry Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafin Fior","family":"Mure\u0219anu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S1474-4422(18)30415-0","article-title":"1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury","year":"2019","unstructured":"1. GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016, Lancet Neurol, 2019;18(1):56-87","journal-title":"Lancet Neurol"},{"issue":"12","key":"ref2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","article-title":"Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research","volume":"16","author":"Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A","year":"2017","unstructured":"2. Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research, Lancet Neurol, 2017;16(12):987-1048","journal-title":"Lancet Neurol"},{"issue":"10267","key":"ref3","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1016\/S0140-6736(20)32340-0","article-title":"Global estimates of the need for rehabilitation based on the Global Burden of Disease Study 2019","volume":"396","author":"Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, Vos T","year":"2020","unstructured":"3. Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, Vos T, Global estimates of the need for rehabilitation based on the Global Burden of Disease Study 2019, Lancet, 2020;396(10267):2006-2017","journal-title":"Lancet"},{"key":"ref4","article-title":"Rehabilitation need estimator","author":"World Health Organization","unstructured":"4. World Health Organization, Rehabilitation need estimator, [Internet], Geneva:WHO, c2023 Available from: https:\/\/vizhub.healthdata.org\/rehabilitation\/","journal-title":"[Internet]"},{"issue":"23","key":"ref5","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1089\/neu.2014.3352","article-title":"Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes","volume":"32","author":"Bramlett HM, Dietrich WD","year":"2015","unstructured":"5. Bramlett HM, Dietrich WD, Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes, J Neurotrauma, 2015;32(23):1834-1848","journal-title":"J Neurotrauma"},{"issue":"3","key":"ref6","doi-asserted-by":"publisher","first-page":"436","DOI":"10.25122\/jml-2022-0120","article-title":"Evaluation of post-traumatic stress disorder (PTSD) and related comorbidities in clinical studies","volume":"15","author":"Mure\u0219anu IA, Grad DA, Mure\u0219anu DF, Dobran SA, Hapca E Strilciuc\u0219","year":"2022","unstructured":"6. Mure\u0219anu IA, Grad DA, Mure\u0219anu DF, Dobran SA, Hapca E Strilciuc\u0219, Evaluation of post-traumatic stress disorder (PTSD) and related comorbidities in clinical studies, J Med Life, 2022;15(3):436-442","journal-title":"J Med Life"},{"issue":"8","key":"ref7","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1001\/jamaneurol.2021.2043","article-title":"Functional outcomes over the first year after moderate to severe traumatic brain injury in the prospective, longitudinal TRACK-TBI study","volume":"78","author":"McCrea MA, Giacino JT, Barber J, Temkin NR, Nelson LD, Levin HS","year":"2021","unstructured":"7. McCrea MA, Giacino JT, Barber J, Temkin NR, Nelson LD, Levin HS, Functional outcomes over the first year after moderate to severe traumatic brain injury in the prospective, longitudinal TRACK-TBI study, JAMA Neurol, 2021;78(8):982-992","journal-title":"JAMA Neurol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fneur.2019.00120","article-title":"A detailed overview of long-term outcomes in severe traumatic brain injury eight years post-injury","volume":"10","author":"Ruet A, Bayen E, Jourdan C, Ghout I, Meaude L, Lalanne A","year":"2019","unstructured":"8. Ruet A, Bayen E, Jourdan C, Ghout I, Meaude L, Lalanne A, A detailed overview of long-term outcomes in severe traumatic brain injury eight years post-injury, Front Neurol, 2019;10120","journal-title":"Front Neurol"},{"issue":"5","key":"ref9","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s00213-020-05482-3","article-title":"Chrysin attenuates traumatic brain injury-induced recognition-memory decline and anxiety\/depression-like behaviours in rats","volume":"237","author":"Rashno M, Ghaderi S, Nesari A, Khorsandi L, Farbood Y, Sarkaki A","year":"2020","unstructured":"9. Rashno M, Ghaderi S, Nesari A, Khorsandi L, Farbood Y, Sarkaki A, Chrysin attenuates traumatic brain injury-induced recognition-memory decline and anxiety\/depression-like behaviours in rats, Psychopharmacology (Berl), 2020;237(5):1607-1619","journal-title":"Psychopharmacology (Berl)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.euroneuro.2019.12.103","article-title":"Pharmacological and non-pharmacological interventions of depression after traumatic brain injury: a systematic review","volume":"33","author":"Du J, Wang S, Yu X, Zhang X, Zhang S, Yuan G","year":"2020","unstructured":"10. Du J, Wang S, Yu X, Zhang X, Zhang S, Yuan G, Pharmacological and non-pharmacological interventions of depression after traumatic brain injury: a systematic review, Eur Neuropsychopharmacol, 2020;33108-125","journal-title":"Eur Neuropsychopharmacol"},{"issue":"6","key":"ref11","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1017\/S0033291715002986","article-title":"A prospective examination of Axis I psychiatric disorders in the first 5 years following moderate to severe traumatic brain injury","volume":"46","author":"Alway Y, Gould KR, Johnston L, McKenzie D, Ponsford J","year":"2016","unstructured":"11. Alway Y, Gould KR, Johnston L, McKenzie D, Ponsford J, A prospective examination of Axis I psychiatric disorders in the first 5 years following moderate to severe traumatic brain injury, Psychol Med, 2016;46(6):1331-1341","journal-title":"Psychol Med"},{"issue":"19","key":"ref12","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1001\/jama.2010.599","article-title":"Rates of major depressive disorder and clinical outcomes following traumatic brain injury","volume":"303","author":"Bombardier CH, Fann JR, Temkin NR, Esselman PC, Barber J, Dikmen SS","year":"2010","unstructured":"12. Bombardier CH, Fann JR, Temkin NR, Esselman PC, Barber J, Dikmen SS, Rates of major depressive disorder and clinical outcomes following traumatic brain injury, JAMA, 2010;303(19):1938-1945","journal-title":"JAMA"},{"issue":"5","key":"ref13","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3390\/jcm10051035","article-title":"Unmet rehabilitation needs after traumatic brain injury across Europe: results from the CENTER-TBI study","volume":"10","author":"Andelic N, R\u00f8e C, Tenovuo O, Azouvi P, Dawes H, Majdan M","year":"2021","unstructured":"13. Andelic N, R\u00f8e C, Tenovuo O, Azouvi P, Dawes H, Majdan M, Unmet rehabilitation needs after traumatic brain injury across Europe: results from the CENTER-TBI study, J Clin Med, 2021;10(5):1035","journal-title":"J Clin Med"},{"issue":"5","key":"ref14","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s10072-019-04181-y","article-title":"Efficacy and safety of Cerebrolysin in neurorecovery after moderate-severe traumatic brain injury: results from the CAPTAIN II trial","volume":"41","author":"Muresanu DF, Florian S, H\u00f6mberg V, Matula C, von Steinb\u00fcchel N, Vos PE","year":"2020","unstructured":"14. Muresanu DF, Florian S, H\u00f6mberg V, Matula C, von Steinb\u00fcchel N, Vos PE, Efficacy and safety of Cerebrolysin in neurorecovery after moderate-severe traumatic brain injury: results from the CAPTAIN II trial, Neurol Sci, 2020;41(5):1171-1181","journal-title":"Neurol Sci"},{"issue":"3","key":"ref15","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/s10072-021-05089-2","article-title":"Cerebrolysin for stroke, neurodegeneration, and traumatic brain injury: review of the literature and outcomes","volume":"42","author":"Fiani B , Covarrubias C, Wong A, Doan T, Reardon T, Nikolaidis D","year":"2021","unstructured":"15. Fiani B , Covarrubias C, Wong A, Doan T, Reardon T, Nikolaidis D, Cerebrolysin for stroke, neurodegeneration, and traumatic brain injury: review of the literature and outcomes, Neurol Sci, 2021;42(3):1345-1353","journal-title":"Neurol Sci"},{"issue":"3","key":"ref16","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/brainsci13030507","article-title":"Cerebrolysin in patients with traumatic brain injury: systematic review and meta-analysis","volume":"13","author":"Jarosz K, Kojder K, Andrzejewska A, Solek-Pastuszka J, Jurczak A","year":"2023","unstructured":"16. Jarosz K, Kojder K, Andrzejewska A, Solek-Pastuszka J, Jurczak A, Cerebrolysin in patients with traumatic brain injury: systematic review and meta-analysis, Brain Sci, 2023;13(3):507","journal-title":"Brain Sci"},{"issue":"10","key":"ref17","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1080\/02699052.2019.1641747","article-title":"Clinical practice guidelines for rehabilitation in traumatic brain injury: a critical appraisal","volume":"33","author":"Lee SY, Amatya B, Judson R, Truesdale M, Reinhardt JD, Uddin T","year":"2019","unstructured":"17. Lee SY, Amatya B, Judson R, Truesdale M, Reinhardt JD, Uddin T, Clinical practice guidelines for rehabilitation in traumatic brain injury: a critical appraisal, Brain Inj, 2019;33(10):1263-1271","journal-title":"Brain Inj"},{"key":"ref18","article-title":"Contractului-cadru pentru 2021-2022 \u015fi normele de aplicare [Internet]","author":"Casa Na\u0163ional\u0103 de Asigur\u0103ri S\u0103n\u0103tate","year":"2021","unstructured":"18. Casa Na\u0163ional\u0103 de Asigur\u0103ri S\u0103n\u0103tate, Contractului-cadru pentru 2021-2022 \u015fi normele de aplicare [Internet], Bucharest:CNAS, 2021;Available from: http:\/\/www.casan.ro\/castl\/post\/type\/local\/contractului-cadru-pentru-2021-2022-si-normele-de-aplicare.html"},{"issue":"4","key":"ref19","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1891\/088970107805059580","article-title":"Rehabilitation policy and practice in Romania: implications for training","volume":"21","author":"Rak EC","year":"2007","unstructured":"19. Rak EC, Rehabilitation policy and practice in Romania: implications for training, Rehabil Educ, 2007;21(4):277-283","journal-title":"Rehabil Educ"},{"issue":"3","key":"ref20","first-page":"272","article-title":"Actual data on epidemiological evolution and prevention endeavours regarding traumatic brain injury","volume":"8","author":"Popescu C, Anghelescu A, Daia C, Onose G","year":"2015","unstructured":"20. Popescu C, Anghelescu A, Daia C, Onose G, Actual data on epidemiological evolution and prevention endeavours regarding traumatic brain injury, J Med Life, 2015;8(3):272-277","journal-title":"J Med Life"},{"issue":"11","key":"ref21","doi-asserted-by":"publisher","first-page":"801","DOI":"10.2340\/16501977-2216","article-title":"Rehabilitation after traumatic brain injury: a survey in 70 European neurotrauma centres participating in the CENTER-TBI study","volume":"51","author":"von Steinb\u00fcchel N, Wilson L, Sutcavage T, Marwitz J","year":"2019","unstructured":"21. von Steinb\u00fcchel N, Wilson L, Sutcavage T, Marwitz J, Rehabilitation after traumatic brain injury: a survey in 70 European neurotrauma centres participating in the CENTER-TBI study, J Rehabil Med, 2019;51(11):801-808","journal-title":"J Rehabil Med"},{"key":"ref22","article-title":"Methods for the Economic Evaluation of Health Care Programmes","author":"Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW","year":"2015","unstructured":"22. Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW, Methods for the Economic Evaluation of Health Care Programmes, Oxford:Oxford University Press, 2015;"},{"key":"ref23","article-title":"GBD Compare","author":"Institute for Health Metrics and Evaluation","unstructured":"23. Institute for Health Metrics and Evaluation, GBD Compare, [Internet], Seattle:IHME; c2023 [cited 2023 Jul 20] Available from: http:\/\/vizhub.healthdata.org\/gbd-compare","journal-title":"[Internet]"},{"key":"ref24","article-title":"COVID-19 vaccine tracker","author":"European Centre for Disease Prevention and Control","year":"2023","unstructured":"24. European Centre for Disease Prevention and Control, COVID-19 vaccine tracker, [Internet], Stockholm:ECDC, 2023;Available from: https:\/\/vaccinetracker.ecdc.europa.eu\/","journal-title":"[Internet]"},{"key":"ref25","article-title":"Vaccination and immunization statistics","author":"United Nations Children\u2019s Fund","year":"2023","unstructured":"25. United Nations Children\u2019s Fund, Vaccination and immunization statistics, [Internet], New York:UNICEF, 2023;Available from: https:\/\/data.unicef.org\/topic\/child-health\/immunization\/","journal-title":"[Internet]"},{"key":"ref26","article-title":"Romania: Country Health Profile 2021","author":"OECD\/European Observatory on Health Systems and Policies","year":"2021","unstructured":"26. OECD\/European Observatory on Health Systems and Policies, Romania: Country Health Profile 2021, Paris:OECD, 2021;"},{"issue":"10","key":"ref27","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3390\/healthcare11101497","article-title":"Cost-effectiveness of Cerebrolysin after ischemic stroke: secondary analysis of the CARS study","volume":"11","author":"Strilciuc S, Radu C, Grad DA, Stan AD, Vl\u0103descu C, Buzoianu AD","year":"2023","unstructured":"27. Strilciuc S, Radu C, Grad DA, Stan AD, Vl\u0103descu C, Buzoianu AD, Cost-effectiveness of Cerebrolysin after ischemic stroke: secondary analysis of the CARS study, Healthcare (Basel), 2023;11(10):1497","journal-title":"Healthcare (Basel)"},{"issue":"7","key":"ref28","doi-asserted-by":"publisher","first-page":"A705","DOI":"10.1016\/j.jval.2015.09.2645","article-title":"Cost-effectiveness analysis of Cerebrolysin in the treatment of acute ischemic stroke of moderate and severe severity in the Russian Federation","volume":"18","author":"Kulikov A, Abdrashitova G","year":"2015","unstructured":"28. Kulikov A, Abdrashitova G, Cost-effectiveness analysis of Cerebrolysin in the treatment of acute ischemic stroke of moderate and severe severity in the Russian Federation, Value Health, 2015;18(7):A705","journal-title":"Value Health"},{"issue":"7","key":"ref29","doi-asserted-by":"publisher","first-page":"A390","DOI":"10.1016\/j.jval.2015.09.865","article-title":"Cost-effectiveness of combined treatment with alteplase (rt-PA) and Cerebrolysin in acute ischemic hemispheric stroke in Austria","volume":"18","author":"Walter E, Bauer M, Ressl S","year":"2015","unstructured":"29. Walter E, Bauer M, Ressl S, Cost-effectiveness of combined treatment with alteplase (rt-PA) and Cerebrolysin in acute ischemic hemispheric stroke in Austria, Value Health, 2015;18(7):A390","journal-title":"Value Health"},{"issue":"7","key":"ref30","doi-asserted-by":"publisher","first-page":"A699","DOI":"10.1016\/j.jval.2015.09.2612","article-title":"Budget impact analysis of Cerebrolysin in acute ischemic stroke of moderate and severe severity in the Russian Federation","volume":"18","author":"Kulikov A, Abdrashitova G","year":"2015","unstructured":"30. Kulikov A, Abdrashitova G, Budget impact analysis of Cerebrolysin in acute ischemic stroke of moderate and severe severity in the Russian Federation, Value Health, 2015;18(7):A699","journal-title":"Value Health"},{"issue":"5","key":"ref31","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3390\/jcm11051273","article-title":"Role and impact of Cerebrolysin for ischemic stroke care","volume":"11","author":"Mure\u0219anu DF, Livin\u021b Popa L, Chira D, D\u0103bal\u0103 V, Hapca E, Vlad I","year":"2022","unstructured":"31. Mure\u0219anu DF, Livin\u021b Popa L, Chira D, D\u0103bal\u0103 V, Hapca E, Vlad I, Role and impact of Cerebrolysin for ischemic stroke care, J Clin Med, 2022;11(5):1273","journal-title":"J Clin Med"},{"key":"ref32","article-title":"ISRCTN17097163: Can Cerebrolysin improve recovery after traumatic brain injury?","author":"ISRCTN Registry","year":"2018","unstructured":"32. ISRCTN Registry, ISRCTN17097163: Can Cerebrolysin improve recovery after traumatic brain injury?, [Internet], London:ISRCTN, 2018;Available from: https:\/\/www.isrctn.com\/ISRCTN17097163","journal-title":"[Internet]"},{"issue":"17","key":"ref33","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1089\/neu.2020.7527","article-title":"A manual for the Glasgow Outcome Scale-Extended interview","volume":"38","author":"Wilson L, Boase K, Nelson LD, Temkin NR, Giacino JT, Markowitz AJ","year":"2021","unstructured":"33. Wilson L, Boase K, Nelson LD, Temkin NR, Giacino JT, Markowitz AJ, A manual for the Glasgow Outcome Scale-Extended interview, J Neurotrauma, 2021;38(17):2435-2446","journal-title":"J Neurotrauma"},{"issue":"1","key":"ref34","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1097\/PCC.0000000000003121","article-title":"Outcome measurement in children with disorders of consciousness after severe brain injury","volume":"24","author":"Ludwig NN, Suskauer SJ, Rodgin S, Chen J, Borda A, Jones K","year":"2023","unstructured":"34. Ludwig NN, Suskauer SJ, Rodgin S, Chen J, Borda A, Jones K, Outcome measurement in children with disorders of consciousness after severe brain injury, Pediatr Crit Care Med, 2023;24(1):e76-e84","journal-title":"Pediatr Crit Care Med"},{"issue":"6","key":"ref35","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/neu.2011.2272","article-title":"Validity of a pediatric version of the Glasgow Outcome Scale\u2013Extended","volume":"29","author":"Beers SR, Wisniewski SR, Garcia-Filion P, Tian Y, Hahner T, Berger RP","year":"2012","unstructured":"35. Beers SR, Wisniewski SR, Garcia-Filion P, Tian Y, Hahner T, Berger RP, Validity of a pediatric version of the Glasgow Outcome Scale\u2013Extended, J Neurotrauma, 2012;29(6):1126-1139","journal-title":"J Neurotrauma"},{"issue":"5","key":"ref36","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1093\/occmed\/kqu024","article-title":"The Hospital Anxiety and Depression Scale","volume":"64","author":"Stern AF","year":"2014","unstructured":"36. Stern AF, The Hospital Anxiety and Depression Scale, Occup Med (Lond), 2014;64(5):393-394","journal-title":"Occup Med (Lond)"},{"issue":"6","key":"ref37","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The Hospital Anxiety and Depression Scale","volume":"67","author":"Zigmond AS, Snaith RP","year":"1983","unstructured":"37. Zigmond AS, Snaith RP, The Hospital Anxiety and Depression Scale, Acta Psychiatr Scand, 1983;67(6):361-370","journal-title":"Acta Psychiatr Scand"},{"issue":"4","key":"ref38","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0163-8343(03)00043-4","article-title":"A validation study of the Hospital Anxiety and Depression Scale in a Spanish population","volume":"25","author":"Herrero MJ, Blanch J, Peri JM, de Pablo J, Pintor L, Bulbena A","year":"2003","unstructured":"38. Herrero MJ, Blanch J, Peri JM, de Pablo J, Pintor L, Bulbena A, A validation study of the Hospital Anxiety and Depression Scale in a Spanish population, Gen Hosp Psychiatry, 2003;25(4):277-283","journal-title":"Gen Hosp Psychiatry"},{"issue":"4","key":"ref39","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1600-0447.1997.tb10164.x","article-title":"Hospital Anxiety and Depression Scale (HAD): some psychometric data for a Swedish sample","volume":"96","author":"Lisspers J, Nygren A, S\u00f6derman E","year":"1997","unstructured":"39. Lisspers J, Nygren A, S\u00f6derman E, Hospital Anxiety and Depression Scale (HAD): some psychometric data for a Swedish sample, Acta Psychiatr Scand, 1997;96(4):281-286","journal-title":"Acta Psychiatr Scand"},{"issue":"2","key":"ref40","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/13548500500524088","article-title":"Validation study of a Portuguese version of the Hospital Anxiety and Depression Scale","volume":"12","author":"Pais-Ribeiro J, Silva I, Ferreira T, Martins A, Meneses R, Baltar M","year":"2007","unstructured":"40. Pais-Ribeiro J, Silva I, Ferreira T, Martins A, Meneses R, Baltar M, Validation study of a Portuguese version of the Hospital Anxiety and Depression Scale, Psychol Health Med, 2007;12(2):225-235","journal-title":"Psychol Health Med"},{"issue":"2","key":"ref41","first-page":"148","article-title":"Validation of the Slovenian version of the Hospital Anxiety and Depression Scale in female cancer patients","volume":"20","author":"Miklavcic IV, Snoj Z, Mlakar J, Pregelj P","year":"2008","unstructured":"41. Miklavcic IV, Snoj Z, Mlakar J, Pregelj P, Validation of the Slovenian version of the Hospital Anxiety and Depression Scale in female cancer patients, Psychiatr Danub, 2008;20(2):148-152","journal-title":"Psychiatr Danub"},{"issue":"2","key":"ref42","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0022-3999(01)00296-3","article-title":"The validity of the Hospital Anxiety and Depression Scale: an updated literature review","volume":"52","author":"Bjelland I, Dahl AA, Haug TT, Neckelmann D","year":"2002","unstructured":"42. Bjelland I, Dahl AA, Haug TT, Neckelmann D, The validity of the Hospital Anxiety and Depression Scale: an updated literature review, J Psychosom Res, 2002;52(2):69-77","journal-title":"J Psychosom Res"},{"issue":"2","key":"ref43","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jval.2015.02.001","article-title":"Cost-effectiveness analysis alongside clinical trials II: an ISPOR Good Research Practices Task Force report","volume":"18","author":"Ramsey SD, Willke RJ, Glick H, Reed SD, Augustovski F, Jonsson B","year":"2015","unstructured":"43. Ramsey SD, Willke RJ, Glick H, Reed SD, Augustovski F, Jonsson B, Cost-effectiveness analysis alongside clinical trials II: an ISPOR Good Research Practices Task Force report, Value Health, 2015;18(2):161-172","journal-title":"Value Health"},{"key":"ref44","article-title":"CaNaMed\u2014National catalogue of medicine prices","author":"Romanian Ministry of Health","year":"2023","unstructured":"44. Romanian Ministry of Health, CaNaMed\u2014National catalogue of medicine prices, [Internet], Bucharest:MoH, 2023;[cited 2023 Mar 20] Available from: http:\/\/preturi.ms.ro\/download.php","journal-title":"[Internet]"},{"key":"ref45","article-title":"Curs euro \u2013 Curs EUR","author":"National Bank of Romania","year":"2023","unstructured":"45. National Bank of Romania, Curs euro \u2013 Curs EUR, [Internet], Bucharest:NBR, 2023;[cited 2023 Sep 26] Available from: https:\/\/www.cursbnr.ro\/curs-euro","journal-title":"[Internet]"},{"issue":"4","key":"ref46","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1080\/02699052.2021.1878556","article-title":"An economic evaluation of decompressive craniectomy for refractory traumatic intracranial hypertension","volume":"35","author":"Behranwala R, Aojula N, Hagana A, Houbby N, de Preux DL","year":"2021","unstructured":"46. Behranwala R, Aojula N, Hagana A, Houbby N, de Preux DL, An economic evaluation of decompressive craniectomy for refractory traumatic intracranial hypertension, Brain Inj, 2021;35(4):444-452","journal-title":"Brain Inj"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"127","DOI":"10.2147\/NDT.S186865","article-title":"Effects of Cerebrolysin on functional outcome after traumatic brain injury: a systematic review and meta-analysis","volume":"15","author":"Ghaffarpasand F, Torabi S, Rasti A, Niakan MH, Aghabaklou S, Pakzad F","year":"2019","unstructured":"47. Ghaffarpasand F, Torabi S, Rasti A, Niakan MH, Aghabaklou S, Pakzad F, Effects of Cerebrolysin on functional outcome after traumatic brain injury: a systematic review and meta-analysis, Neuropsychiatr Dis Treat, 2019;15127-135","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1210017","DOI":"10.3389\/fnins.2023.1210017","article-title":"Cerebrolysin and repetitive transcranial magnetic stimulation in patients with traumatic brain injury: a three-arm randomised trial","volume":"17","author":"Verisezan Ro\u0219u O, Jemna N, Hapca E, Benedek I, Vadan I, Mure\u0219anu I","year":"2023","unstructured":"48. Verisezan Ro\u0219u O, Jemna N, Hapca E, Benedek I, Vadan I, Mure\u0219anu I, Cerebrolysin and repetitive transcranial magnetic stimulation in patients with traumatic brain injury: a three-arm randomised trial, Front Neurosci, 2023;171210017","journal-title":"Front Neurosci"},{"issue":"5","key":"ref49","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3390\/medicina58050648","article-title":"The effect of Cerebrolysin on anxiety, depression, and cognition in moderate and severe traumatic brain injury patients: a CAPTAIN II retrospective analysis","volume":"58","author":"Mure\u0219anu IA, Grad DA, Mure\u0219anu DF, Hapca E, Benedek I, Jemna N","year":"2022","unstructured":"49. Mure\u0219anu IA, Grad DA, Mure\u0219anu DF, Hapca E, Benedek I, Jemna N, The effect of Cerebrolysin on anxiety, depression, and cognition in moderate and severe traumatic brain injury patients: a CAPTAIN II retrospective analysis, Medicina (Kaunas), 2022;58(5):648","journal-title":"Medicina (Kaunas)"},{"issue":"2","key":"ref50","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s10072-019-04053-5","article-title":"Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I trial","volume":"41","author":"Poon W, Matula C, Vos PE, Muresanu DF, von Steinb\u00fcchel N, von Wild K","year":"2020","unstructured":"50. Poon W, Matula C, Vos PE, Muresanu DF, von Steinb\u00fcchel N, von Wild K, Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I trial, Neurol Sci, 2020;41(2):281-293","journal-title":"Neurol Sci"},{"issue":"5","key":"ref51","doi-asserted-by":"publisher","first-page":"700","DOI":"10.25122\/jml-2021-0362","article-title":"C-REGS 2: design and methodology of a comparative effectiveness observational trial","volume":"14","author":"Vester J, Bornstein N, Heiss W-D, Vosko M, Moessler H, Jech M","year":"2021","unstructured":"51. Vester J, Bornstein N, Heiss W-D, Vosko M, Moessler H, Jech M, C-REGS 2: design and methodology of a comparative effectiveness observational trial, J Med Life, 2021;14(5):700-709","journal-title":"J Med Life"},{"key":"ref52","article-title":"HTA 101: introduction to health technology assessment","author":"National Information Center on Health Services Research and Health Care Technology","year":"2023","unstructured":"52. National Information Center on Health Services Research and Health Care Technology, HTA 101: introduction to health technology assessment, [Internet], Bethesda (MD):U.S. National Library of Medicine, 2023;Available from: https:\/\/www.nlm.nih.gov\/nichsr\/hta101\/ta10103.html","journal-title":"[Internet]"},{"issue":"7","key":"ref53","doi-asserted-by":"publisher","first-page":"A444","DOI":"10.1016\/j.jval.2014.08.1177","article-title":"Romanian Quick-HTA development in 2013","volume":"17","author":"Radu CP, Cernea R","year":"2014","unstructured":"53. Radu CP, Cernea R, Romanian Quick-HTA development in 2013, Value Health, 2014;17(7):A444","journal-title":"Value Health"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.vhri.2016.07.006","article-title":"Development of the Romanian scorecard HTA system","volume":"10","author":"Radu CP, Chiriac ND, Pravat AM","year":"2016","unstructured":"54. Radu CP, Chiriac ND, Pravat AM, Development of the Romanian scorecard HTA system, Value Health Reg Issues, 2016;1041-47","journal-title":"Value Health Reg Issues"},{"issue":"7","key":"ref55","doi-asserted-by":"publisher","first-page":"A634","DOI":"10.1016\/j.jval.2016.09.1661","article-title":"Transparency in health technology assessment in Hungary, Romania and Turkey","volume":"19","author":"Subtirelu M, Mic OC, Daneasa D, Csanadi M, Atikeler K, Dogan E","year":"2016","unstructured":"55. Subtirelu M, Mic OC, Daneasa D, Csanadi M, Atikeler K, Dogan E, Transparency in health technology assessment in Hungary, Romania and Turkey, Value Health, 2016;19(7):A634-A635","journal-title":"Value Health"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"S200","DOI":"10.1016\/j.jval.2018.09.1186","article-title":"PHP292\u2014roadmap for implementation of health technology assessment in Romania","volume":"21","author":"Rais C, Kal\u00f3 Z, Csan\u00e1di M, Negulescu V","year":"2018","unstructured":"56. Rais C, Kal\u00f3 Z, Csan\u00e1di M, Negulescu V, PHP292\u2014roadmap for implementation of health technology assessment in Romania, Value Health, 2018;21(Suppl 2):S200","journal-title":"Value Health"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1192\/bjp.188.4.337","article-title":"Cost-effectiveness and cost-utility of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine: randomised controlled trial","volume":"188","author":"Kendrick T, Peveler R, Longworth L, Baldwin D, Moore M, Chatwin J","year":"2006","unstructured":"57. Kendrick T, Peveler R, Longworth L, Baldwin D, Moore M, Chatwin J, Cost-effectiveness and cost-utility of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine: randomised controlled trial, Br J Psychiatry, 2006;188337-345","journal-title":"Br J Psychiatry"},{"issue":"7","key":"ref58","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1002\/hec.4487","article-title":"Mapping between EQ-5D-3L and EQ-5D-5L: a survey experiment on the validity of multi-instrument data","volume":"31","author":"Hern\u00e1ndez-Alava M, Pudney S","year":"2022","unstructured":"58. Hern\u00e1ndez-Alava M, Pudney S, Mapping between EQ-5D-3L and EQ-5D-5L: a survey experiment on the validity of multi-instrument data, Health Econ, 2022;31(7):923-939","journal-title":"Health Econ"},{"issue":"3","key":"ref59","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s10198-022-01481-7","article-title":"EQ-5D-5L: a value set for Romania","volume":"24","author":"Olariu E, Mohammed W, Oluboyede Y, Caplescu R, Niculescu-Aron IG, Paveliu MS","year":"2023","unstructured":"59. Olariu E, Mohammed W, Oluboyede Y, Caplescu R, Niculescu-Aron IG, Paveliu MS, EQ-5D-5L: a value set for Romania, Eur J Health Econ, 2023;24(3):399-412","journal-title":"Eur J Health Econ"},{"issue":"12","key":"ref60","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1007\/s40273-023-01301-7","article-title":"Conducting trial-based economic evaluations using R: a tutorial","volume":"41","author":"Ben \u00c2J, van Dongen JM, El Alili M, Esser JL, Broul\u00edkov\u00e1 HM, Bosmans JE","year":"2023","unstructured":"60. Ben \u00c2J, van Dongen JM, El Alili M, Esser JL, Broul\u00edkov\u00e1 HM, Bosmans JE, Conducting trial-based economic evaluations using R: a tutorial, Pharmacoeconomics, 2023;41(12):1403-1413","journal-title":"Pharmacoeconomics"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/all-issues\/2025\/issue-4-2025\/original-article-issue-4-2025\/cost-effectiveness-of-cerebrolysin-as-an-add-on-treatment-for-neurorecovery-after-traumatic-brain-injury\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:51:17Z","timestamp":1752076277000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/all-issues\/2025\/issue-4-2025\/original-article-issue-4-2025\/cost-effectiveness-of-cerebrolysin-as-an-add-on-treatment-for-neurorecovery-after-traumatic-brain-injury\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["JMedLife-18-387"],"URL":"https:\/\/doi.org\/10.25122\/jml-2025-0087","relation":{},"ISSN":["1844-3117"],"issn-type":[{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}