{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:09:45Z","timestamp":1788772185664,"version":"build-2803163510"},"reference-count":17,"publisher":"S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.25122\/jml-2026-0062","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:34:12Z","timestamp":1788770052000},"page":"316-321","source":"Crossref","is-referenced-by-count":0,"title":["Effects of vitamin K administration on liver function, inflammation, and coagulation in chronic viral hepatitis: a retrospective study"],"prefix":"10.25122","volume":"19","author":[{"given":"Magdalena","family":"Lixandru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Faculty of Medicine, Lucian Blaga University, Sibiu, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionela","family":"Maniu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Mathematics and Informatics Department, Faculty of Sciences, Research Center in Informatics and Information Technology, Lucian Blaga University, Sibiu, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pediatric Clinical Hospital Sibiu, Sibiu, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmin Ionu\u021b","family":"Lixandru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Faculty of Medicine, Lucian Blaga University, Sibiu, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Grosu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Faculty of Medicine, Lucian Blaga University, Sibiu, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10755","reference":[{"issue":"8","key":"ref1","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1111\/j.1538-7836.2005.01419.x","article-title":"The vitamin K cycle","volume":"3","author":"Stafford DW","year":"2005","unstructured":"1. Stafford DW, The vitamin K cycle, J Thromb Haemost, 2005;3(8):1873-1878","journal-title":"J Thromb Haemost"},{"issue":"5","key":"ref2","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1055\/s-0028-1104531","article-title":"Key pathways and regulators of vitamin K function and metabolism","volume":"34","author":"Shearer MJ, Okano T","year":"2008","unstructured":"2. Shearer MJ, Okano T, Key pathways and regulators of vitamin K function and metabolism, Semin Thromb Hemost, 2008;34(5):530-538","journal-title":"Semin Thromb Hemost"},{"issue":"2","key":"ref3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"Tripodi A, Mannucci PM","year":"2011","unstructured":"3. Tripodi A, Mannucci PM, The coagulopathy of chronic liver disease, N Engl J Med, 2011;365(2):147-156","journal-title":"N Engl J Med"},{"issue":"3","key":"ref4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nri1573","article-title":"Immunology of hepatitis B virus and hepatitis C virus infection","volume":"5","author":"Rehermann B, Nascimbeni M","year":"2005","unstructured":"4. Rehermann B, Nascimbeni M, Immunology of hepatitis B virus and hepatitis C virus infection, Nat Rev Immunol, 2005;5(3):215-29","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"ref5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3350\/cmh.2016.0069","article-title":"New perspectives of biomarkers for the management of chronic hepatitis B","volume":"22","author":"Lin CL, Kao JH","year":"2016","unstructured":"5. Lin CL, Kao JH, New perspectives of biomarkers for the management of chronic hepatitis B, Clin Mol Hepatol, 2016;22(4):423-431","journal-title":"Clin Mol Hepatol"},{"issue":"3","key":"ref6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/aje\/kwm306","article-title":"Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study","volume":"167","author":"Shea MK, Booth SL, Massaro JM, Jacques PF, D\u2019Agostino RB Sr, Dawson-Hughes B","year":"2008","unstructured":"6. Shea MK, Booth SL, Massaro JM, Jacques PF, D\u2019Agostino RB Sr, Dawson-Hughes B, Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study, Am J Epidemiol, 2008;167(3):313-20","journal-title":"Am J Epidemiol"},{"issue":"9","key":"ref7","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1111\/j.1537-2995.2005.00546.x","article-title":"Transfusion Medicine\/Hemostasis Clinical Trials Network. Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review","volume":"45","author":"Segal JB, Dzik WH","year":"2005","unstructured":"7. Segal JB, Dzik WH, Transfusion Medicine\/Hemostasis Clinical Trials Network. Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review, Transfusion, 2005;45(9):1413-1425","journal-title":"Transfusion"},{"issue":"6","key":"ref8","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1182\/blood-2010-02-261891","article-title":"Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences","volume":"116","author":"Lisman T, Porte RJ","year":"2010","unstructured":"8. Lisman T, Porte RJ, Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences, Blood, 2010;116(6):878-85","journal-title":"Blood"},{"issue":"1","key":"ref9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nrendo.2012.201","article-title":"The role of osteocalcin in human glucose metabolism: marker or mediator?","volume":"9","author":"Booth SL, Centi A, Smith SR, Gundberg C","year":"2013","unstructured":"9. Booth SL, Centi A, Smith SR, Gundberg C, The role of osteocalcin in human glucose metabolism: marker or mediator?, Nat Rev Endocrinol, 2013;9(1):43-55","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"ref10","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3945\/jn.113.187740","article-title":"Dietary intake of vitamin K is inversely associated with mortality risk","volume":"144","author":"Juanola-Falgarona M, Salas-Salvad\u00f3 J, Mart\u00ednez-Gonz\u00e1lez M\u00c1, Corella D, Estruch R, Ros E","year":"2014","unstructured":"10. Juanola-Falgarona M, Salas-Salvad\u00f3 J, Mart\u00ednez-Gonz\u00e1lez M\u00c1, Corella D, Estruch R, Ros E, Dietary intake of vitamin K is inversely associated with mortality risk, J Nutr, 2014;144(5):743-750","journal-title":"J Nutr"},{"issue":"11","key":"ref11","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.jnutbio.2009.09.011","article-title":"Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor \u03baB through the repression of IKK\u03b1\/\u03b2 phosphorylation","volume":"21","author":"Ohsaki Y, Shirakawa H, Miura A, Hiwatashi K, Furukawa Y, Mizutani T","year":"2010","unstructured":"11. Ohsaki Y, Shirakawa H, Miura A, Hiwatashi K, Furukawa Y, Mizutani T, Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor \u03baB through the repression of IKK\u03b1\/\u03b2 phosphorylation, J Nutr Biochem, 2010;21(11):1120-1126","journal-title":"J Nutr Biochem"},{"issue":"1","key":"ref12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1055\/s-2002-23205","article-title":"Coagulation disorders in liver disease","volume":"22","author":"Amitrano L, Guardascione MA, Brancaccio V, Balzano A","year":"2002","unstructured":"12. Amitrano L, Guardascione MA, Brancaccio V, Balzano A, Coagulation disorders in liver disease, Semin Liver Dis, 2002;22(1):83-96","journal-title":"Semin Liver Dis"},{"issue":"4","key":"ref13","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1002\/hep.21303","article-title":"Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management","volume":"44","author":"Caldwell SH, Hoffman M, Lisman T","year":"2006","unstructured":"13. Caldwell SH, Hoffman M, Lisman T, Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management, Hepatology, 2006;44(4):1039-1046","journal-title":"Hepatology"},{"issue":"1","key":"ref14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/MBC.0b013e32835975ed","article-title":"The coagulopathy of liver disease: does vitamin K help?","volume":"24","author":"Saja MF, Abdo AA, Sanai FM, Shaikh SA, Gader AG","year":"2013","unstructured":"14. Saja MF, Abdo AA, Sanai FM, Shaikh SA, Gader AG, The coagulopathy of liver disease: does vitamin K help?, Blood Coagul Fibrinolysis, 2013;24(1):10-7","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"3","key":"ref15","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/phar.1716","article-title":"Impact of vitamin K administration on INR changes and bleeding events among patients with cirrhosis","volume":"36","author":"Meyer AV, Levin BC, Kashiouris M","year":"2016","unstructured":"15. Meyer AV, Levin BC, Kashiouris M, Impact of vitamin K administration on INR changes and bleeding events among patients with cirrhosis, Pharmacotherapy, 2016;36(3):279-284","journal-title":"Pharmacotherapy"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"10760296211050923","DOI":"10.1177\/10760296211050923","article-title":"Appropriateness of Using Vitamin K for the Correction of INR Elevation Secondary to Hepatic Disease in Critically ill Patients: An Observational Study","volume":"27","author":"Al Sulaiman K, Al Mutairi M, Al Harbi O, Al Duraihim A, Aldosary S, Al Khalil H","year":"2021","unstructured":"16. Al Sulaiman K, Al Mutairi M, Al Harbi O, Al Duraihim A, Aldosary S, Al Khalil H, Appropriateness of Using Vitamin K for the Correction of INR Elevation Secondary to Hepatic Disease in Critically ill Patients: An Observational Study, Clin Appl Thromb Hemost, 2021;2710760296211050923","journal-title":"Clin Appl Thromb Hemost"},{"issue":"9","key":"ref17","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cgh.2013.02.026","article-title":"Coagulation in liver disease: a guide for the clinician","volume":"11","author":"Northup PG, Caldwell SH","year":"2013","unstructured":"17. Northup PG, Caldwell SH, Coagulation in liver disease: a guide for the clinician, Clin Gastroenterol Hepatol, 2013;11(9):1064-74","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Journal of Medicine and Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medandlife.org\/all-issues\/2026\/issue-4-2026\/original-article-issue-4-2026\/effects-of-vitamin-k-administration-on-liver-function-inflammation-and-coagulation-in-chronic-viral-hepatitis-a-retrospective-study\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:34:28Z","timestamp":1788770068000},"score":1,"resource":{"primary":{"URL":"https:\/\/medandlife.org\/all-issues\/2026\/issue-4-2026\/original-article-issue-4-2026\/effects-of-vitamin-k-administration-on-liver-function-inflammation-and-coagulation-in-chronic-viral-hepatitis-a-retrospective-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["JMedLife-19-316"],"URL":"https:\/\/doi.org\/10.25122\/jml-2026-0062","relation":{},"ISSN":["1844-3117"],"issn-type":[{"value":"1844-3117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}